Detalles de la búsqueda
1.
Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL-286, a novel retinoic acid receptor-ß agonist for treatment of spinal cord injury, in male healthy participants.
Br J Clin Pharmacol
; 89(12): 3573-3583, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37452623
2.
Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells.
J Neurosci
; 39(16): 3013-3027, 2019 04 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-30760627
3.
Discovery and lead optimisation of a potent, selective and orally bioavailable RARß agonist for the potential treatment of nerve injury.
Bioorg Med Chem Lett
; 29(8): 995-1000, 2019 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30792038
4.
Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth.
Neurobiol Dis
; 111: 70-79, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29274429
5.
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.
Bioorg Med Chem
; 26(4): 798-814, 2018 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29288071
6.
Neuronal RARß Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration.
J Neurosci
; 35(47): 15731-45, 2015 Nov 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26609164
7.
Corrigendum to "Discovery and lead optimisation of a potent, selective and orally bioavailable RARß agonist for the potential treatment of nerve injury" [Bioorg. Med. Chem. Lett. 29(8) (2019) 995-1000].
Bioorg Med Chem Lett
; 29(16): 2440-2441, 2019 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31208764
8.
Amyloid ß inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist.
Eur J Neurosci
; 37(7): 1182-92, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23379615
9.
Drug repurposing for Alzheimer's disease based on transcriptional profiling of human iPSC-derived cortical neurons.
Transl Psychiatry
; 9(1): 220, 2019 09 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31492831
10.
RARß Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms.
iScience
; 20: 554-566, 2019 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31655065
11.
Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 18(1): 375-9, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18061448
12.
Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement.
J Med Chem
; 46(12): 2275-8, 2003 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12773031
13.
RARß Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms.
iScience
; 21: 562-563, 2019 Nov 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-31726373
14.
Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.
J Med Chem
; 52(11): 3441-4, 2009 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-19432431
15.
3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
Bioorg Med Chem Lett
; 16(14): 3839-42, 2006 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16682202
16.
Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes.
J Biol Chem
; 281(42): 31279-89, 2006 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-16899457
17.
4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 16(2): 280-4, 2006 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16275079
18.
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.
J Biol Chem
; 280(13): 12523-35, 2005 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15613471
19.
Cyclic sulfamide gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 15(19): 4212-6, 2005 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16054361
20.
A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.
Bioorg Med Chem Lett
; 15(2): 373-8, 2005 Jan 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-15603957