RESUMEN
Estrogen receptor protein was found in 24% of colonic neoplasms. Presence of estrogen receptor activity was independent of age or sex of the patient, state of differentiation or spread of the tumor, and concentration of carcinoembryonic antigen in the tumor. Estrogen receptor activity in colon tumors probably reflects novel protein synthesis resulting from dedifferentiation. Measurement of tumor estrogen receptor protein and carcinoembryonic antigen may have discriminatory value in the patient with metastatic adenocarcinoma and an unknown primary neoplasm.
Asunto(s)
Adenocarcinoma/análisis , Antígeno Carcinoembrionario/análisis , Neoplasias del Colon/análisis , Receptores de Estrógenos , Factores de Edad , Anciano , Sangre , Femenino , Humanos , Persona de Mediana EdadRESUMEN
Standardization of surgical procedures is both feasible and necessary in clinical trials. To the extent that an operation may influence prognosis, identify prognostic factors, or reveal variables upon which additional treatment is contingent, the operation must be defined precisely enough to permit the determinations to be made uniformly and to enable the surgeons to meet the necessary standardization. If uniform procedures are to be applied widely, surgeons who participate in therapeutic trials must meet the standards of clinical scientists and accept special obligations for eduction and self-discipline.