Safety and efficacy of zero fluoroscopy transseptal puncture with different approaches.

INTRODUCTION: Atrial fibrillation (AF) ablation requires access to the left atrium (LA) via transseptal puncture (TP). TP is traditionally performed with fluoroscopic guidance. Use of intracardiac echocardiography (ICE) and three-dimensional mapping allows for zero fluoroscopy TP. OBJECTIVE: To demonstrate safety and efficacy of zero fluoroscopy TP using multiple procedural approaches. METHODS: Patients undergoing AF ablation between January 2015 and November 2017 at five institutions were included. ICE and three-dimensional mapping were used for sheath positioning and TP. Variable technical approaches were used across centers including placement of J wire in the superior vena cava with ICE guidance followed by dragging down the transseptal sheath into the interatrial septum, or guiding the transseptal sheath directly to the interatrial septum by localizing the ablation catheter with three-dimensional mapping and replacing it with the transseptal needle once in position. In patients with pacemaker/implantable cardiac defibrillator leads, pre-/poststudy device interrogation was performed. RESULTS: A total of 747 TPs were performed (646 patients, age 63.1 ± 13.1, 67.5% male, LA volume index 34.5 ± 15.8 mL/m2 , ejection fraction 57.7 ± 10.9%) with 100% success. No punctures required fluoroscopy. Two pericardial effusions, two pericardial tamponades requiring pericardiocentesis, and one transient ischemic attack were observed during the overall ablation procedure, with a total complication rate of 0.7%. There were no other periprocedural complications related to TP, including intrathoracic bleeding, stroke, or death both immediately following TP and within 30 days of the procedure. In patients with intracardiac devices, no device-related complications were observed. CONCLUSION: TP can be safely and effectively performed without the need for fluoroscopy.

Reversibility of medically unresponsive pulmonary hypertension with nesiritide in a cardiac transplant recipient.

Pulmonary hypertension unresponsive to medical therapy is considered by most centers to be a contraindication for orthotopic cardiac transplantation. This article describes a patient with unresponsive severe pulmonary hypertension who, despite a combination of maximal doses of dobutamine, milrinone, and nitroprusside infusion, responded to nesiritide (Natrecor) infusion with improvement in pulmonary hemodynamics. The patient was considered a high risk for transplantation because of significant pulmonary hypertension in spite of maximum oral therapy and continuous intravenous milrinone. Severe irreversible pulmonary hypertension persisted with a combination of dobutamine, milrinone, and nitroprusside, with pulmonary artery pressure (PA) of 88/44 mm Hg, a transpulmonary gradient (TPG) of 27, and pulmonary vascular resistance (PVR) of 5.79 Wood units. Upon addition of nesiritide, within 24 hours, there was a sustained decrease in PA to 47/30, TPG of 15, and PVR of 3.75 Wood units. The patient underwent successful left ventricular assist device placement soon after nesiritide infusion demonstrated reversibility of pulmonary hypertension. He subsequently underwent uneventful orthotopic cardiac transplantation and has done well with normal right heart pressures. This case illustrates that addition of nesiritide to standard therapy can reverse significant unresponsive pulmonary hypertension and make a patient eligible for left ventricular assist device and orthotopic cardiac transplantation.

Hyperhomocysteinemia and deep vein thrombosis in orthotopic heart transplantation: a case report.

Homocysteine has been recognized as a risk factor for atherosclerosis and arterial and venous thrombosis. Heart transplant patients have an increased prevalence of hyperhomocysteinemia. High homocysteine levels in transplant patients may promote development of cardiac allograft vasculopathy, but there is minimal information regarding the risk of venous thrombosis. The current case report illustrates the association of increased levels of homocysteine and hypercoagulable syndrome in a 36-year-old heart transplant patient with no previous history of clotting disorder. Both elevated homocysteine levels and extensive venous thrombosis responded promptly to treatment with a folate/B12/B6 vitamin combination and enoxaparin.