Layer-Dependent Magnetic Structure and Anomalous Hall Effect in the Magnetic Topological Insulator MnBi4Te7.

The intrinsic antiferromagnetic topological insulator (TI) MnBi4Te7 provides a capacious playground for the realization of topological quantum phenomena, such as the axion insulator states and quantum anomalous Hall (QAH) effect. In addition to nontrivial band topology, magnetism is another necessary ingredient for realizing these quantum phenomena. Here, we investigate signatures of thickness-dependent magnetism in exfoliated MnBi4Te7 thin flakes. We observe an obvious odd-even layer-number effect in few-layer MnBi4Te7. Noticeably, we show that in monolayer MnBi4Te7 the anomalous Hall effect exhibits a sign reversal. Compared with the case of MnBi2Te4, interlayer antiferromagnetic exchange coupling, which is essential for the realization of the QAH effect, is greatly suppressed in MnBi4Te7. The demonstration of thickness-dependent magnetic properties is helpful to further explore the topological quantum phenomena in MnBi4Te7.

Superconductivity at 40 K in Lithiation-Processed [(Fe,Al)(OH)2][FeSe]1.2 with a Layered Structure.

Exploration of new superconductors has always been one of the research directions in condensed matter physics. We report here a new layered heterostructure of [(Fe,Al)(OH)2][FeSe]1.2, which is synthesized by the hydrothermal ion-exchange technique. The structure is suggested by a combination of X-ray powder diffraction and the electron diffraction (ED). [(Fe,Al)(OH)2][FeSe]1.2 is composed of the alternating stacking of a tetragonal FeSe layer and a hexagonal (Fe,Al)(OH)2 layer. In [(Fe,Al)(OH)2][FeSe]1.2, there exists a mismatch between the FeSe sublayer and the (Fe,Al)(OH)2 sublayer, and the lattice of the layered heterostructure is quasi-commensurate. The as-synthesized [(Fe,Al)(OH)2][FeSe]1.2 is nonsuperconducting due to the Fe vacancies in the FeSe layer. The superconductivity with a Tc of 40 K can be achieved after a lithiation process, which is due to the elimination of the Fe vacancies in the FeSe layer. The Tc is nearly the same as that of (Li,Fe)OHFeSe although the structure of [(Fe,Al)(OH)2][FeSe]1.2 is quite different from that of (Li,Fe)OHFeSe. The new layered heterostructure of [(Fe,Al)(OH)2][FeSe]1.2 contains an iron selenium tetragonal lattice interleaved with a hexagonal metal hydroxide lattice. These results indicate that the superconductivity is very robust for FeSe-based superconductors. It opens a path for exploring superconductivity in iron-base superconductors.

A Joint Symbol-Detection, Channel-Estimation and Decoding Scheme under Few-Bit ADCs in mmWave Communications.

Few-bit analog-to-digital converter (ADC) is regarded as a promising technique to greatly reduce power consumption of Internet of Things (IoT) devices in millimeter-wave (mmWave) communications. In this work, based on the recently proposed parametric bilinear generalized approximate message passing (PBiGAMP), we propose a new scheme to perform joint symbol detection, channel estimation and decoding. The proposed scheme is flexible to deal with discrete prior on symbols, Gaussian mixture prior on channels and quantized likelihood on observations. Furthermore, we introduce doping factor to control the portion of "extrinsic" and "posterior" information with negligible complexity increase. Since this joint scheme can be implemented via fast Fourier transformation (FFT), the complexity grows only logarithmically. Compared to the benchmark algorithms, numerical results show that the proposed joint scheme can achieve significant performance gain, and demonstrate the effectiveness in dealing with the nonlinear distortion from few-bit ADC.

Distributed Joint Cooperative Self-Localization and Target Tracking Algorithm for Mobile Networks.

: Location information is a key issue for applications of the Internet of Things. In this paper, we focus on mobile wireless networks with moving agents and targets. The positioning process is divided into two phases based on the factor graph, i.e., a prediction phase and a joint self-location and tracking phase. In the prediction phase, we develop an adaptive prediction model by exploiting the correlation of trajectories within a short period to formulate the prediction message. In the joint positioning phase, agents calculate the cooperative messages according to variational message passing and locate themselves. Simultaneously, the average consensus algorithm is employed to realize distributed target tracking. The simulation results show that the proposed prediction model is adaptive to the random movement of nodes. The performance of the proposed joint self-location and tracking algorithm is better than the separate cooperative self-localization and tracking algorithms.

Molecular binding behavior of water-soluble calix[4]arenes with asymmetric 4,4'-bipyridinium guests in aqueous solution: regioselective recognition or not?

The molecular binding behavior of water-soluble calix[4]arenes (p-sulfonatocalix[4]arene (SC4A) and p-sulfonatothiacalix[4]arene (STC4A)) with two asymmetric 4,4'-bipyridinium guests (N-methyl-N'-adamantane carbomethyl-4,4'-bipyridinium dibromide (MVAd2+) and N-methyl-N'-(naphthalen-2-ylmethyl)-4,4'-bipyridinium bromide iodide (MVNp2+)) was systematically studied using NMR spectroscopy and microcalorimetry in a neutral aqueous solution. Either the methyl group or the adamantane moiety in MVAd2+ could enter into the SC4A and STC4A cavities, without regioselectivity. The STC4A cavity can also accommodate MVNp2+, either through incorporation of the methyl group or the naphthalene moiety, without regioselectivity. However, we were surprised to find that MVNp2+ could only be included within the SC4A cavity through incorporation of the methyl group, with regioselectivity, which is rare for a flexible host. Furthermore, both SC4A and STC4A can form stable inclusion complexes with the two investigated asymmetric 4,4'-bipyridinium guests, driven by very favorable enthalpy changes, and the thermodynamic origins of the host selectivities for MVAd2+ and MVNp2+ can be well explained through their binding modes. The finding of this novel regioselective recognition is promising for potential applications in the development of more sophisticated biomimetic materials.

A calixpyridinium-based supramolecular tandem assay for alkaline phosphatase and its application to ATP hydrolysis reaction.

We have successfully implemented the supramolecular tandem assay principle for the real-time, continuous, direct, and label-free monitoring of alkaline phosphatase activity through a fluorescence "switch-off" assay based on a novel calixpyridinium/dye reporter pair. Because several diseases can be preliminarily diagnosed in light of an abnormal level of alkaline phosphatase in serum, the application of tandem assays to selectively monitor alkaline phosphatase activity has feasible implications in disease diagnosis.

Transfer of orbital angular momentum through sub-wavelength waveguides.

Data capacity of optical communication is achieving its limit owing to the non-linear effect of optical fiber. As an effective alternative, light carrying orbital angular momentum can greatly increase the capacity for its unprecedented degree of freedom. We demonstrate the propagation of orbital angular momentum with topological charge of 1 and 2 in plasmonic circular waveguide with sub-wavelength diameter with little propagation loss of 2.73 dB/µm, which has never been observed in optical fibers with sub-wavelength diameter. We also confirm that lights carrying orbital angular momentum can be maintained in sharp bended sub-wavelength waveguide. This plasmonic waveguide may serve as a key component in on-chip systems involving OAM.

Optical phased array radiating optical vortex with manipulated topological charges.

Optical antennas are key elements in quantum optics emitting and sensing, and behave wide range applications in optical domain. However, integration of optical antenna radiating orbital angular momentum is still a challenge in nano-scale. We theoretically demonstrate a sub-wavelength phased optical antenna array, which manipulates the distribution of the orbital angular momentum in the near field. Orbital angular momentum with topological charge of 4 can be obtained by controlling the phase distribution of the fundamental mode orbital angular momentum in each antenna element. Our results indicate this phased array may be utilized in high integrated optical communication systems.

Rapid production of a H9 N2 influenza vaccine from MDCK cells for protecting chicken against influenza virus infection.

H9N2 subtype avian influenza viruses are widespread in domestic poultry, and vaccination remains the most effective way to protect the chicken population from avian influenza pandemics. Currently, egg-based H9N2 influenza vaccine production has several disadvantages and mammalian MDCK cells are being investigated as candidates for influenza vaccine production. However, little research has been conducted on low pathogenic avian influenza viruses (LPAIV) such as H9N2 replicating in mammalian cells using microcarrier beads in a bioreactor. In this study, we present a systematic analysis of a safe H9N2 influenza vaccine derived from MDCK cells for protecting chickens against influenza virus infection. In 2008, we isolated two novel H9N2 influenza viruses from chickens raised in southern China, and these H9N2 viruses were adapted to MDCK cells. The H9N2 virus was produced in MDCK cells in a scalable bioreactor, purified, inactivated, and investigated for use as a vaccine. The MDCK-derived H9N2 vaccine was able to induce high titers of neutralizing antibodies in chickens of different ages. Histopathological examination, direct immunofluorescence, HI assay, CD4(+)/CD8(+) ratio test, and cytokine evaluation indicated that the MDCK-derived H9N2 vaccine evoked a rapid and effective immune response to protect chickens from influenza infection. High titers of H9N2-specific antibodies were maintained in chickens for 5 months, and the MDCK-derived H9N2 vaccine had no effects on chicken growth. The use of MDCK cells in bioreactors for LPAIV vaccine production is an attractive option to prevent outbreaks of LPAIV in poultry.

The effects of Tai Chi on standing balance control in older adults may be attributed to the improvement of sensory reweighting and complexity rather than reduced sway velocity or amplitude.

Introduction: Tai Chi has proved to be an effective therapy for balance performance and cognition. However, non-consistency exists in the results of the effect of Tai Chi training on standing balance control in older adults. This study aimed to use traditional and non-traditional methods to investigate the effect of Tai Chi on standing balance in older adults. Methods: Thirty-six Tai Chi practitioners (TC group) and thirty-six older adults with no Tai Chi practice (control group) were recruited in this study. A Nintendo Wii Balance Board was used to record the center of pressure (COP) during standing balance over 20 s in the condition of eyes closed with three repetitions. The wavelet analysis, multiscale entropy, recurrence quantification analysis, and traditional methods were used to evaluate the standing balance control in the anterior-posterior (AP) and mediolateral (ML) directions. Results: (1) Greater sway mean velocity in the AP direction and sway Path length were found in the TC group compared with the control group; (2) lower Very-low frequency band (0.10-0.39 Hz) and higher Moderate frequency band (1.56-6.25 Hz) in the AP and ML directions were found in the TC group compared with the control group; (3) greater complexity index (CI) and lower determinism (DET) in the AP and ML directions were observed in the TC group compared with control group; (4) greater path length linked with smaller Very-low frequency band in the AP and ML directions and higher Moderate frequency band in the AP direction in both groups; (5) greater path length linked with lower DET and higher CI in the AP direction only in the TC group. Conclusion: Long-term Tai Chi practice improved sensory reweighting (more reliance on the proprioception system and less reliance on the vestibular system) and complexity of standing balance control in older adults. In addition, greater sway velocity may be as an exploratory role in standing balance control of TC older adults, which correlated with greater complexity, but no such significant relationship in the control group. Therefore, the effects of Tai Chi practice on standing balance control in older adults may be attributed to the improvement of sensory reweighting and complexity rather than reduced sway velocity or amplitude.

Construction and enhancement of government capacity for international communication and promotion of Chinese Wushu.

BACKGROUND: In the process of international communication in Chinese Wushu (ICCW), the government controls the orientation, scale, pace. However, the ICCW currently lacks a standardised government capacity structural system, and a detailed study of framework construction may be required to ensure the smooth development of the ICCW. OBJECTIVES: This study aims to clarify these elements and construct a framework for a governmental capacity system for ICCW. METHODS: For this purpose, an expert interview outline was designed, and in-depth interviews were conducted with 61 experts. Using grounded theory in the qualitative research method, NVivo 12 software was used to conduct a three-level coding analysis of the interview text for data processing and analysis. RESULTS: We extracted 58 opening codes and 11 tree nodes and categorised them into three core categories: supply side government capacity, environment-side government capacity, and demand-side government capacity, accounting for 62.36 %, 24.76 %, and 12.86 % of the total, respectively, which jointly constructed the framework structure system of the governmental capacity system for the ICCW. CONCLUSIONS: This study found that these three-dimensional government capacities have synergistic effects and that multiple measures work together. The government should ensure the supply side's direct promotion effect; the environmental side's indirect influencing effect; and the demand side's internal driving effect to promote ICCW. Meanwhile, a closed-loop systematic study of communication processes should be conducted in combination with communication organisations and individuals.

Resveratrol inhibits NF-kB signaling through suppression of p65 and IkappaB kinase activities.

Resveratrol has been shown to possess multiple pharmacological activities including anti-tumor, anti-inflammation and immunomodulation, and participates in the regulation of the NF-kappaB signaling pathway. However, the mechanism of the NF-kappaB signaling pathway inhibited by resveratrol remains obscure. In this study, we first examined the effect of resveratrol on endogenous and TNF-alpha-induced NF-kappaB activation, and found that resveratrol suppressed NF-kappaB activation in a dose dependent manner. Resveratrol reduced the transcriptional activity of p65, but neither affected the DNA-binding activity of NF-kappaB nor blocked the nuclear translocation of p65. Moreover, resveratrol had no effect on the expression level of IkappaBalpha protein and inhibited IkappaBalpha degradation. Further investigation revealed that resveratrol blocked the ubiquitination of NEMO and inhibited IkappaB kinase(beta)-mediated NF-kappaB activation. These results demonstrated that resveratrol effectively suppressed NF-kappaB signaling through inhibiting the activities of NF-kappaB and IkappaB kinase. Therefore, resveratrol may provide a novel approach to treating inflammation-associated diseases and cancer.

Hsa_circ_0005273 acts as a sponge of miR-509-3p to promote the malignant behaviors of breast cancer by regulating HMMR expression.

BACKGROUND: Breast cancer (BC) is a common malignant tumor that threatens the health of women worldwide. Hsa_circ_0005273 has been identified as a carcinogenic factor in some solid tumors, including BC. However, the molecular mechanism of circ_0005273 in BC is poorly defined. METHODS: The expression of circ_0005273, miR-509-3p, and hyaluronan-mediated motility receptor (HMMR) mRNA in BC was detected by quantitative real-time polymerase chain reaction. Cell proliferation, migration, invasion, and apoptosis were detected by 5-ethynyl-2'-deoxyuridine, transwell, and flow cytometry assays. The glycolysis level was detected via specific kits. Western blot was used to detect protein expression. Binding between miR-509-3p and circ_0005273 or HMMR was also verified by dual-luciferase reporter, RNA pull-down, and RNA immunoprecipitation assays. Xenograft tumor model was used to detect tumor changes in mice, and immunohistochemistry assay was employed to detect Ki-67 abundance. RESULTS: Circ_0005273 was increased in BC tissues and cells. Circ_0005273 knockdown might inhibit BC cell proliferation, migration, invasion, glutamine metabolism, and induce apoptosis. Circ_0005273 was a miR-509-3p, and the repression role of circ_0005273 absence on BC cell development was weakened by miR-509-3p inhibitor or HMMR overexpression. Circ_0005273 up-regulated the expression of HMMR by sponging miR-509-3p. Additionally, circ_0005273 silencing might hinder tumor growth in vivo. CONCLUSION: Circ_0005273 knockdown might repress BC cell malignant behaviors by regulating the miR-509-3p/HMMR axis, which might provide a potential therapeutic target for BC.

[Sperm DNA damage in young men working on the plateau].

OBJECTIVE: To investigate whether long working in the high-altitude area can damage sperm DNA in men. METHODS: We enlisted 51 service men stationed on the plateau in an observation group and another 53 living in the low-altitude area in a control group. We detected and compared the damages to sperm DNA in the semen samples from the two groups using single cell gel electrophoresis and the sperm chromatin dispersion test. RESULTS: The percentages of total, G1, G2 and G3 comet cells and abnormal sperm of the observation group were (5.56 +/- 3.98)%, (3.72 +/- 1.85)%, (1.57 +/- 1.07)%, (0.27 +/- 0.34)% and (16.59 +/- 12.07)%, respectively, before stationed on the plateau, but significantly increased at 6 months of plateau life ([11.15 +/- 8.59]%, [5.97 +/- 3.26]%, [3.83 +/- 2.13%, [1.35 +/- 1.53]% and [22.03 +/- 15.33]%, P<0.05). The percentages of G2 comet cells and abnormal sperm were decreased to (3.32 +/- 1.83)% and (20.54 +/- 15.52)% at 12 months, but still significantly higher than the baseline (P<0.05). CONCLUSION: Long working on the plateau may damage sperm DNA, but its influence on male fertility deserves further investigation. Therefore, it is important to reinforce reproductive health protection for males working on the plateau.

Cyclic Behavior of Autoclaved Aerated Concrete External Panel with New Connector.

In this paper, a new slip-type crossing connector is proposed for autoclaved aerated concrete (ALC) panels with steel frames, and the proposed connector is also studied deeply in terms of seismic performance. The research included pseudo-static tests and finite element simulations. First, the seismic performance of slip-type crossing connectors and standard L-hooked bolts was studied comparatively, including the stability, bearing capacity, stiffness, energy dissipation, and hysteresis performance. ABAQUS 2020 software was used to establish finite element models, and the results of the experiments were verified with simulations on the basis. According to the simulations, a parameter analysis of connector optimization was carried out. The effects of connector thickness and connector plate length on the seismic performance were further investigated. From the experimental and simulation results, the slip-type crossing connector has excellent performance and good assembly efficiency, it can improve the deficiencies of the existing connectors. The comparison demonstrated that the slip-type crossing connector has a complete hysteresis curve, a high energy dissipation capacity, and a 9.7% increase in bearing capacity. The appropriate reduction in connector thickness and plate length can ensure superior seismic performance while saving resources. The finite analysis method can guide the design and implementation of new external ALC panel connectors.

Hypoxia-induced circRNF13 promotes the progression and glycolysis of pancreatic cancer.

Pancreatic cancer (PC) is one of the most malignant tumors. Rapid progression and distant metastasis are the main causes of patient death. Hypoxia is a hallmark of multiple cancers and is involved in tumor biology. However, little is known about the roles of circRNAs in glycolysis and hypoxia-mediated progression of PC. Here, the expression pattern of hypoxia-related circRNAs was analyzed using RNA sequencing. A unique circRNA termed circRNF13 was found to be upregulated in PC tissues and may be a potential prognostic indicator. HIF-1α and EIF4A3 are involved in regulating the biogenesis of circRNF13. Furthermore, circRNF13 was validated to exert a stimulative effect on cell proliferation, angiogenesis, invasion and glycolysis. Importantly, we found that circRNF13 promoted PDK3 levels by acting as a miR-654-3p sponge, thus promoting the PC malignant process. Collectively, our results reveal that hypoxia-induced circRNF13 mediated by HIF-1α and EIF4A3 promotes tumor progression and glycolysis in PC, indicating the potential of circRNF13 as a prognostic biomarker and therapeutic target for PC.

Altitude can alter the mtDNA copy number and nDNA integrity in sperm.

OBJECTIVE: Mitochondria are factories for energy production and genetic alterations in mtDNA will directly impact OXPHOS function. The copy number of mtDNA (i.e., the number of mtDNA per spermatozoon) is one of the major mitochondrial genetic features. Besides mtDNA copy number, the change of either mtDNA or nDNA integrity is another important factor causing asthenospermia, or poor sperm motility in infertile men. In this study, we investigated the mtDNA copy number and the integrities of mtDNA and nDNA respectively in semen samples from different donors at 5,300 m altitudes. METHODS: Total DNA was extracted from semen samples from donors in two different altitudes. Quantitative PCR was performed to evaluate the mtDNA copy number. PCR amplification was used to examine the integrity of sperm mtDNA. Flow cytometry was carried out to investigate sperm nDNA integrity. All data were analyzed to show the statistical significance. RESULTS: Sperm mtDNA copy number for those living at high altitude (5,300 m) for one month was significantly higher (P < 0.05) than for those at the lower altitude (1,400 m) or in donors who had been living at the 5,300 m altitude for 1 year. In addition, sperm mtDNA copy numbers were remarkably decreased (P < 0.05) in those who had lived at the greater altitude for 1 year compared to those who had lived there for one month. The ratio of nDNA integrity among the 10,000 sperms at high altitude for one month was significantly lower (P < 0.05) than that at the lower altitude (1,400 m) or at 5,300 m for 1 year, and the ratio of nDNA integrity sperms at high altitude for 1 year was increased, and higher than that for at the lower altitude (P < 0.05). CONCLUSION: High altitude can alter the mtDNA copy number and nDNA integrity in the sperms.

Manipulating Ferromagnetism in Few-Layered Cr2 Ge2 Te6.

The discovery of magnetism in 2D materials offers new opportunities for exploring novel quantum states and developing spintronic devices. In this work, using field-effect transistors with solid ion conductors as the gate dielectric (SIC-FETs), we have observed a significant enhancement of ferromagnetism associated with magnetic easy-axis switching in few-layered Cr2 Ge2 Te6 . The easy axis of the magnetization, inferred from the anisotropic magnetoresistance, can be uniformly tuned from the out-of-plane direction to an in-plane direction by electric field in the few-layered Cr2 Ge2 Te6 . Additionally, the Curie temperature, obtained from both the Hall resistance and magnetoresistance measurements, increases from 65 to 180 K in the few-layered sample by electric gating. Moreover, the surface of the sample is fully exposed in the SIC-FET device configuration, making further heterostructure-engineering possible. This work offers an excellent platform for realizing electrically controlled quantum phenomena in a single device.

Analysis of two sequence variants in peroxisome proliferator-activated receptor gamma gene in a Tibetan population at high altitude and a Han population at low altitude in China.

BACKGROUND: The Tibetan people in China have lived at high altitude for thousands of years, raising the possibility that the Tibetans are genetically adapted to high altitude. In this study we analyzed the Pro12Ala (C>G) polymorphism in exon 2 and the 161C>T polymorphism in exon 6 of peroxisome proliferator-activated receptor gamma gene (PPARγ) in a Tibetan population and a Han population. MATERIAL/METHODS: We recruited 142 Tibetan volunteers who are permanent inhabitants in Qingzang plateau (higher elevation) and 266 Han volunteers who are permanent inhabitants in the plain (lower elevation). PCR/RFLP method was applied to examine the 2 polymorphisms in the 2 populations. RESULTS: Significantly higher Pro12Ala (C>G) CC genotype frequency and 161C>T CC genotype frequency were observed in the Tibetan population compared to the Han population (p<0.001). When the samples were stratified by sex, significant differences were only observed in females. The haplotypes constructed by Pro12Ala (C>G) and 161C>T were also analyzed. The frequency of the haplotype CC (p<0.0001) was significantly higher, while the frequency of the haplotype CT (p<0.0001) and GT (p<0.01) was significantly lower in the Tibetan population than in the Han population. CONCLUSIONS: Our results suggested that PPARγ might be a candidate gene for high-altitude adaptation; the Pro12Ala (C>G) CC genotype and/or the 161C>T CC genotype are possibly advantageous factors in the female Tibetan population. Alternatively, the difference of the Pro12Ala (C>G) genotype distribution and /or the difference of the 161C>T genotype distribution in the 2 populations may be due to the racial difference.

Circ_0007031 enhances tumor progression and promotes 5-fluorouracil resistance in colorectal cancer through regulating miR-133b/ABCC5 axis.

Colorectal cancer (CRC) remains one of the most commonly diagnosed malignancies worldwide. Circular RNAs (circRNAs) are being found to play crucial roles in human cancer, including CRC. The purpose of this study was to explore the function and mechanism of circ_0007031 on CRC progression and 5-fluorouracil (5-FU) resistance. The levels of circ_0007031, ATP-binding cassette subfamily C member 5 (ABCC5) and miR-133b were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Cell survival and proliferation were detected by the 3-(4,5-dimethylthiazol-2yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. Cell colony formation was evaluated using a standard colony formation assay. Transwell assays were performed to determine cell migration and invasion. Targeted correlations among circ_0007031, miR-133b and ABCC5 were verified by dual-luciferase reporter, RNA immunoprecipitation (RIP) and RNA pulldown assays. Animal experiments were performed to observe the role of circ_0007031 in vivo. Our data indicated that circ_0007031 up-regulation was associated with CRC resistance to 5-FU. Circ_0007031 knockdown repressed CRC cell proliferation, migration and invasion and enhanced 5-FU sensitivity. Circ_0007031 directly interacted with miR-133b. Moreover, circ_0007031 knockdown regulated CRC cell progression and 5-FU sensitivity by miR-133b. ABCC5 was a direct target of miR-133b, and circ_0007031 mediated ABCC5 expression via acting as a miR-133b sponge. Furthermore, miR-133b overexpression regulated CRC cell progression and sensitivity to 5-FU by down-regulating ABCC5. Additionally, circ_0007031 knockdown suppressed tumor growth in vivo. Our current work had led to the identification of circ_0007031 knockdown that repressed CRC cell malignant progression and enhanced 5-FU sensitivity via regulating ABCC5 expression by sponging miR-133b.