RESUMEN
We report the case of a 64-year-old male patient diagnosed as having inoperable poorly differentiated liver carcinoma that could be completely resected after systemic chemotherapy with cisplatin and 5-fluorouracil.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Carcinoma de Células Escamosas/tratamiento farmacológico , Carcinoma de Células Escamosas/cirugía , Neoplasias Hepáticas/tratamiento farmacológico , Neoplasias Hepáticas/cirugía , Carcinoma de Células Escamosas/patología , Cisplatino/administración & dosificación , Fluorouracilo/administración & dosificación , Humanos , Neoplasias Hepáticas/patología , Masculino , Persona de Mediana EdadRESUMEN
BACKGROUND: In the present work, we report on the results of our pilot study of hyperthermic isolated hepatic perfusion (IHP) with melphalan alone for patients with unresectable metastatic liver tumors refractory to conventional treatments, with particular regard to the correlation between pharmacokinetic findings and hepatic toxicity. PATIENTS AND METHODS: Inclusion criteria were unresectable liver metastases, hepatic parenchyma replacement Asunto(s)
Antineoplásicos Alquilantes/farmacocinética
, Enfermedad Hepática Inducida por Sustancias y Drogas/etiología
, Neoplasias Hepáticas/tratamiento farmacológico
, Melfalán/farmacocinética
, Adulto
, Anciano
, Antineoplásicos Alquilantes/efectos adversos
, Quimioterapia del Cáncer por Perfusión Regional
, Estudios de Factibilidad
, Femenino
, Humanos
, Hipertermia Inducida
, Neoplasias Hepáticas/secundario
, Neoplasias Hepáticas/cirugía
, Masculino
, Melfalán/efectos adversos
, Persona de Mediana Edad
, Proyectos Piloto
RESUMEN
OBJECTIVE: The purpose of this study is to report a new sonographic appearance of hepatic pseudotumors. These lesions had a targetlike appearance but were caused by spared areas in fatty liver. CONCLUSION: Although representing a frequent pattern in metastases and mycotic abscesses, a central hyperechoic core encircled by a hypoechoic halo has not yet been reported in relation to pseudotumors. Whereas multifocal target lesions in the liver suggest metastases or mycotic abscesses, an isolated target lesion in the fourth hepatic segment requires a differential diagnostic approach and a pseudotumor should be suspected because of its clinical relevance.