The efficacy of Zingiber officinale on dyslipidaemia, blood pressure, and inflammation as cardiovascular risk factors: A systematic review.

BACKGROUND & AIMS: Hypertension, dyslipidaemia, and chronic inflammation contribute to the development of cardiovascular disease (CVD). Zingiber officinale has been suggested to reduce these CVD risk factors; however, the clinical evidence remains unclear. This systematic review aims to analyse the effect of Z. officinale as a sole intervention on these risk factors. METHODS: In this PRISMA-based systematic review, we included randomised clinical trials from PubMed, Scopus and Cochrane Database of Systematic Reviews (July 2020) analysing triglycerides, low- and high-density lipoprotein (LDL, HDL), total cholesterol, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin 1, 6, 10, systolic and/or diastolic blood pressure as outcomes. Quality of studies was evaluated by JADAD and the Cochrane risk-of-bias tools. RESULTS: A total of 24 studies were included, mostly (79.2%) showing low risk of bias. These were based on obesity and cardio-metabolic derangements (33.3%), type 2 diabetes mellitus (37.5%), and miscellaneous conditions (29.2%). While total cholesterol and triglycerides levels mostly improved after Z. officinale, results were inconsistent for other blood lipids markers. Inflammatory markers (CRP, TNF-α) were more consistently reduced by Z. officinale, while only 3 studies reported a non-significant reduction of blood pressure. CONCLUSIONS: Although there remains a paucity of studies, Z. officinale may be beneficial for improving dyslipidaemia and inflammation.

Has Pandemic Threat Stoked Xenophobia? How COVID-19 Influences California Voters' Attitudes toward Diversity and Immigration.

Sociological theory and historical precedent suggest that pandemics engender scapegoating of outgroups, but fail to specify how the ethnoracial boundaries defining outgroups are drawn. Using a survey experiment that primed half of the respondents (California registered voters) with questions about COVID-19 during April 2020, we ask how the pandemic influenced attitudes toward immigration, diversity and affect toward Asian Americans. In the aggregate, the COVID prime did not affect attitudes toward immigrants, but did reduce support for policies opening a pathway to citizenship for undocumented immigrants and reduced appreciation of California's diversity. Respondents reported rarely feeling anger or fear toward Asian Americans, and rates were unaffected by the COVID prime. A non-experimental comparison between attitudes toward immigrants in September 2019 and April 2020 found a positive change, driven by change among Asian-American and Latino respondents. The results provide selective support for the proposition that pandemics engender xenophobia. At least in April 2020 in California, increased bias crimes against Asian Americans more likely reflected politicians' authorization of scapegoating than broad-based racial antagonism.

Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.

Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used class of antidepressant drugs, but the cellular and molecular mechanisms by which their therapeutic action is initiated are poorly understood. Here we show that serotonin 5-HT1B receptors in cholecystokinin (CCK) inhibitory interneurons of the mammalian dentate gyrus (DG) initiate the therapeutic response to antidepressants. In these neurons, 5-HT1B receptors are expressed presynaptically, and their activation inhibits GABA release. Inhibition of GABA release from CCK neurons disinhibits parvalbumin (PV) interneurons and, as a consequence, reduces the neuronal activity of the granule cells. Finally, inhibition of CCK neurons mimics the antidepressant behavioral effects of SSRIs, suggesting that these cells may represent a novel cellular target for the development of fast-acting antidepressant drugs.