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1.
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid.
Arch Toxicol
; 93(4): 1021-1037, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30915487
2.
Use of HµREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds.
Mol Pharm
; 13(8): 2796-807, 2016 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27377099
3.
Significantly Different Covalent Binding of Oxidative Metabolites, Acyl Glucuronides, and S-Acyl CoA Conjugates Formed from Xenobiotic Carboxylic Acids in Human Liver Microsomes.
Chem Res Toxicol
; 28(5): 886-96, 2015 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-25803559
4.
Metabolism of xenobiotic carboxylic acids: focus on coenzyme A conjugation, reactivity, and interference with lipid metabolism.
Chem Res Toxicol
; 26(8): 1139-55, 2013 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-23790050
5.
In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system.
J Pharmacol Exp Ther
; 343(1): 134-44, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22776955
6.
Evaluation of organic anion-transporting polypeptide 1B1 and CYP3A4 activities in primary human hepatocytes and HepaRG cells cultured in a dynamic three-dimensional bioreactor system.
J Pharmacol Exp Ther
; 343(1): 145-56, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22789711
7.
An ex vivo perfusion system emulating in vivo conditions in noncirrhotic and cirrhotic human liver.
J Pharmacol Exp Ther
; 342(3): 730-41, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22674469
8.
Cytochrome P450-dependent metabolism in HepaRG cells cultured in a dynamic three-dimensional bioreactor.
Drug Metab Dispos
; 39(7): 1131-8, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21436404
9.
Investigation of the involvement of P-glycoprotein and multidrug resistance-associated protein 2 in the efflux of ximelagatran and its metabolites by using short hairpin RNA knockdown in Caco-2 cells.
Drug Metab Dispos
; 38(3): 491-7, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20023051
10.
CYP3A4 catalytic activity is induced in confluent Huh7 hepatoma cells.
Drug Metab Dispos
; 38(6): 995-1002, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20233841
11.
Industrial Approach to Determine the Relative Contribution of Seven Major UGT Isoforms to Hepatic Glucuronidation.
J Pharm Sci
; 109(7): 2309-2320, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32294459
12.
Lipopolysaccharide induced-in vivo increases in beta-defensins of the rat parotid gland.
Arch Oral Biol
; 51(9): 769-74, 2006 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16704867
13.
Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies.
J Tissue Eng Regen Med
; 9(9): 1017-26, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23165723
14.
Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies.
Tissue Eng Part C Methods
; 17(5): 549-56, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21210724
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