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1.
Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
Proc Natl Acad Sci U S A
; 114(33): E6942-E6951, 2017 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28760974
2.
Synthesis and pharmacological evaluation of conformationally constrained glutamic acid higher homologues.
Bioorg Med Chem
; 24(22): 5741-5747, 2016 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27658797
3.
Selectivity of 3-bromo-isoxazoline inhibitors between human and Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenases.
Bioorg Med Chem
; 24(12): 2654-9, 2016 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27137361
4.
Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase.
J Enzyme Inhib Med Chem
; 31(2): 295-301, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-25807299
5.
Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation.
Bioorg Med Chem
; 23(21): 7053-60, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26432608
6.
Efficient synthesis of novel glutamate homologues and investigation of their affinity and selectivity profile at ionotropic glutamate receptors.
Bioorg Med Chem Lett
; 24(8): 1980-2, 2014 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24630559
7.
Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-B.
Biochemistry
; 51(27): 5486-95, 2012 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-22703277
8.
Investigating the mechanism of substrate uptake and release in the glutamate transporter homologue Glt(Ph) through metadynamics simulations.
J Am Chem Soc
; 134(1): 453-63, 2012 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-22092197
9.
Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6ß2* nicotinic acetylcholine receptors.
FASEB J
; 25(11): 3775-89, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21778325
10.
Mechanism of falcipain-2 inhibition by α,ß-unsaturated benzo[1,4]diazepin-2-one methyl ester.
J Comput Aided Mol Des
; 26(9): 1035-43, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22965332
11.
A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake.
Bioorg Med Chem
; 20(21): 6344-55, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23022052
12.
The enantiomers of epiboxidine and of two related analogs: synthesis and estimation of their binding affinity at α4ß2 and α7 neuronal nicotinic acetylcholine receptors.
Chirality
; 24(7): 543-51, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22566097
13.
Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a molecular mechanics Poisson-Boltzmann surface area approach.
J Comput Chem
; 29(15): 2593-602, 2008 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-18478580
14.
Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake.
J Pharmacol Exp Ther
; 326(2): 646-56, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18451317
15.
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.
J Med Chem
; 51(7): 2311-5, 2008 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18338843
16.
Drug discovery targeting amino acid racemases.
Chem Rev
; 111(11): 6919-46, 2011 Nov 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-21913633
17.
Synthesis of novel pyrrolo[3,4-d]pyrazole-dicarboxylic acids and evaluation of their interaction with glutamate receptors.
Chem Biodivers
; 5(4): 657-63, 2008 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18421758
18.
Folates in Trypanosoma brucei: Achievements and Opportunities.
ChemMedChem
; 13(20): 2150-2158, 2018 10 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-30152195
19.
Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression.
ChemistryOpen
; 7(11): 858-864, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30397576
20.
Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.
Bioorg Med Chem
; 15(24): 7626-37, 2007 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17889543