Detalles de la búsqueda
1.
Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders.
Molecules
; 26(4)2021 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33668468
2.
High-throughput screening assay for the quantification of Cer d18:1/16:0, d18:1/24:0, d18:1/24:1, d18:1/18:0, d18:1/14:0, d18:1/20:0, and d18:1/22:0 in HepG2 cells using RapidFire mass spectrometry.
Biomed Chromatogr
; 34(5): e4790, 2020 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-31883352
3.
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase.
Bioorg Med Chem Lett
; 28(5): 922-925, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29433927
4.
Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.
Biochem Biophys Res Commun
; 491(2): 416-422, 2017 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-28720493
5.
Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Sci Rep
; 12(1): 15440, 2022 09 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36104373
6.
ATP citrate lyase inhibitor Bempedoic Acid alleviate long term HFD induced NASH through improvement in glycemic control, reduction of hepatic triglycerides & total cholesterol, modulation of inflammatory & fibrotic genes and improvement in NAS score.
Curr Res Pharmacol Drug Discov
; 2: 100051, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34909677
7.
An in vitro model of hepatic steatosis using lipid loaded induced pluripotent stem cell derived hepatocyte like cells.
J Biol Methods
; 7(3): e135, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32934967
8.
PKCdelta mediates Nrf2-dependent protection of neuronal cells from NO-induced apoptosis.
Biochem Biophys Res Commun
; 386(4): 750-6, 2009 Sep 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-19563780
9.
Protein/DNA arrays identify nitric oxide-regulated cis-element and trans-factor activities some of which govern neuroblastoma cell viability.
Nucleic Acids Res
; 35(16): 5439-51, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17702766
10.
High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).
J Med Chem
; 62(21): 9837-9873, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31589440
11.
Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis.
Acta Trop
; 185: 212-218, 2018 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-29802846
12.
A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.
Sci Rep
; 8(1): 3660, 2018 02 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29483571
13.
Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury.
FASEB J
; 20(14): 2624-6, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17142801
14.
c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction.
Oncogene
; 21(34): 5301-12, 2002 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-12149651
15.
Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene.
Oncogene
; 21(14): 2191-200, 2002 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-11948402
16.
Establishment and validation of a 384-well antibacterial assay amenable for high-throughput screening and combination testing.
J Microbiol Methods
; 118: 173-5, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26432950
17.
Development, validation and quantitative assessment of an enzymatic assay suitable for small molecule screening and profiling: A case-study.
Biomol Detect Quantif
; 4: 1-9, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-27077032
18.
Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations.
Sci Rep
; 5: 16025, 2015 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26531810
19.
Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC.
Front Microbiol
; 6: 958, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26441892
20.
Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants.
J Biol Chem
; 280(17): 16891-900, 2005 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-15734732