Detalles de la búsqueda
1.
Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators.
Bioorg Chem
; 138: 106607, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37210829
2.
In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial.
Molecules
; 22(12)2017 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29194347
3.
Sigma receptor and aquaporin modulators: chiral resolution, configurational assignment, and preliminary biological profile of RC752 enantiomers.
J Pharm Biomed Anal
; 239: 115902, 2024 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38101238
4.
Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer.
J Med Chem
; 66(7): 5223-5241, 2023 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36972104
5.
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents.
Eur J Med Chem
; 249: 115163, 2023 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36716640
6.
Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities.
Biomolecules
; 13(5)2023 05 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37238706
7.
Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain.
Pharmaceuticals (Basel)
; 16(7)2023 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37513874
8.
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.
Eur J Med Chem
; 246: 114997, 2023 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36502578
9.
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the ß-Catenin Armadillo Repeats Domain as an Anticancer Agent.
ACS Pharmacol Transl Sci
; 6(7): 1087-1103, 2023 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37470018
10.
Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics.
Cancers (Basel)
; 14(12)2022 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-35740641
11.
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor.
J Med Chem
; 65(23): 15805-15818, 2022 12 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-36395526
12.
Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties.
Eur J Med Chem
; 241: 114615, 2022 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35932568
13.
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.
ACS Med Chem Lett
; 11(5): 754-759, 2020 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32435381
14.
Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer.
Front Pharmacol
; 10: 490, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31156430
15.
In vivo and in vitro ADMET profiling and in vivo pharmacodynamic investigations of a selective α7 nicotinic acetylcholine receptor agonist with a spirocyclic Δ2-isoxazoline molecular skeleton.
Eur J Pharmacol
; 820: 265-273, 2018 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29275158
16.
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.
Eur J Med Chem
; 152: 283-297, 2018 May 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29730191
17.
Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1).
J Med Chem
; 50(7): 1571-83, 2007 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-17352462
18.
Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2).
J Med Chem
; 50(7): 1693-7, 2007 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-17352463
19.
Evaluation of in vitro brain penetration: optimized PAMPA and MDCKII-MDR1 assay comparison.
Int J Pharm
; 345(1-2): 125-33, 2007 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-17624703
20.
New perspectives in bio-analytical techniques for preclinical characterization of a drug candidate: UPLC-MS/MS in in vitro metabolism and pharmacokinetic studies.
J Pharm Biomed Anal
; 44(3): 665-73, 2007 Jul 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-17236736