RESUMEN
Limonene, limonene oxide and eight beta-amino alcohol derivatives obtained by synthesis were investigated for the effect on egg hatchability and mortality rates of newly hatched larvae of the cattle tick Rhipicephalus (Boophilus) microplus. At the doses between 10 microg/ml and 2.5 microg/ml all the compounds were highly lethal to the larvae and some of them showed activity at lower concentrations. The effect on the eggs hatchability was observed in all the treatments.
Asunto(s)
Amino Alcoholes/toxicidad , Ciclohexenos/toxicidad , Insecticidas/toxicidad , Monoterpenos/toxicidad , Rhipicephalus/efectos de los fármacos , Terpenos/toxicidad , Amino Alcoholes/síntesis química , Animales , Monoterpenos Ciclohexánicos , Larva/efectos de los fármacos , Limoneno , Estructura Molecular , Óvulo/efectos de los fármacos , Relación Estructura-ActividadRESUMEN
The antidepressant-like effects of phloroglucinol and seven synthetic related derivatives were investigated using the tail suspension test (TST) in mice. Compounds 2-methyl-1-[2,4,6-trihydroxy-3-(2-methylpropanoyl)phenyl] propan-l-one (5), 1-(2,4,6-trihydroxyphenyl)ethan-l-one (6), 1-(3-acetyl-2,4,6-trihydroxyphenyl)ethan-l-one (7), 2-methyl-1 -[2,4,6-trihydroxy-3-(2-methylpropanoyl)-5-{ [2,4,6-trihydroxy-3,5-bis(2-methylpropanoyl)phenyl]methyl phenyl] propan-1-one (9) and 1-{3-acetyl-5-[(3,5-diacetyl-2,4,6-trihydroxyphenyl)methyl]-2,4,6-trihydroxyphenyl}ethan-1-one (10), containing acyl groups, decreased the immobile behavior of mice treated orally with equimolar doses of imipramine 20 mg/kg, with no alterations in locomotor activity as assessed by the open-field test. These results suggest that these phloroglucinol derivatives could represent a new molecular model in the search for antidepressant drugs.
Asunto(s)
Antidepresivos/farmacología , Suspensión Trasera , Floroglucinol/análogos & derivados , Animales , Masculino , Ratones , Floroglucinol/farmacologíaRESUMEN
This study reports the effect of six hyacinthacine analogues derived from pyrrolizidine alkaloids on egg hatchability and mortality rates of newly hatched larvae of the cattle tick Rhipicephalus (Boophilus) microplus. All the compounds were toxic to the larvae of the ticks and inhibited the eggs hatchability in the higher concentration tested (5 microg/ml). Even in the lowest concentration (0.625 microg/ml), some effect in the eggs hatchability was observed.