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1.
Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J Biol Chem
; 290(33): 20044-59, 2015 Aug 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26085101
2.
Target engagement in lead generation.
Bioorg Med Chem Lett
; 25(5): 998-1008, 2015 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25630223
3.
Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.
Bioorg Med Chem
; 23(5): 996-1010, 2015 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25661449
4.
Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor.
J Med Chem
; 66(23): 15960-15976, 2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37992274
5.
Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.
J Med Chem
; 65(20): 13892-13909, 2022 10 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-36197449
6.
CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis.
EBioMedicine
; 27: 200-213, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-29290411
7.
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Sci Rep
; 8(1): 15458, 2018 10 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-30337562
8.
A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.
J Med Chem
; 60(13): 5933-5939, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28613895
9.
Synthesis and Characterization of Urofuranoic Acids: In Vivo Metabolism of 2-(2-Carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic Acid (CMPF) and Effects on in Vitro Insulin Secretion.
J Med Chem
; 60(5): 1860-1875, 2017 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28171722
10.
Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
J Med Chem
; 60(23): 9807-9820, 2017 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29088532
11.
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J Med Chem
; 60(23): 9599-9616, 2017 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29072452
12.
Progress toward the discovery and development of efficacious BACE inhibitors.
Curr Opin Drug Discov Devel
; 9(6): 776-91, 2006 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17117686
13.
Use of Osmotic Pumps to Establish the Pharmacokinetic-Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors.
J Med Chem
; 59(12): 5810-22, 2016 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27194201
14.
Stereoselective synthesis of 2-deoxy-beta-galactosides via 2-deoxy-2-bromo- and 2-deoxy-2-iodo-galactopyranosyl donors.
Org Lett
; 5(11): 1871-4, 2003 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-12762674
15.
Stereoselective synthesis of functionalized precursors of the CDEF and CDE 2,6-dideoxy-tetra- and trisaccharide units of durhamycins A and B.
Org Lett
; 5(11): 1875-8, 2003 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-12762675
16.
Conversion of glucuronic acid glycosides to novel bicyclic beta-lactams.
Org Lett
; 4(1): 135-8, 2002 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-11772109
17.
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
J Med Chem
; 57(24): 10476-85, 2014 Dec 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25415648
18.
Enantioselective synthesis of alpha-amino acids from N-tosyloxy beta-lactams derived from beta-keto esters.
J Org Chem
; 68(1): 27-34, 2003 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-12515457
19.
An enantioselective synthesis of differentially protected erythro-alpha,beta-diamino acids and its application to the synthesis of an analogue of rhodopeptin B5.
J Org Chem
; 68(1): 35-42, 2003 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-12515458
20.
Total synthesis of formamicin.
J Am Chem Soc
; 126(30): 9307-17, 2004 Aug 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-15281821
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