1.
Bioorg Med Chem
; 27(23): 115148, 2019 12 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-31679980
RESUMEN
In this work, new derivatives of diarylimidazole-1,2,3-triazole 7a-p were designed, synthesized, and evaluated for their in vitro α-glucosidase inhibitory activity. All compounds showed potent inhibitory activity in the range of IC50â¯=â¯90.4-246.7⯵M comparing with acarbose as the standard drug (IC50â¯=â¯750.0⯵M). Among the synthesized compounds, compounds 7b, 7c, and 7e were approximately 8 times more potent than acarbose. The kinetic study of those compounds indicated that they acted as the competitive inhibitors of α-glucosidase. Molecular docking studies were also carried out for compounds 7b, 7c, and 7e using modeled α-glucosidase to find the interaction modes responsible for the desired inhibitory activity.