1.
Bioorg Med Chem Lett
; 19(5): 1380-5, 2009 Mar 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19195882
RESUMEN
Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of a series of quinoline derivatives that were highly potent and selective inhibitors of PDE4 with a good pharmacokinetic profile in the rat. Quinolines 43 and 48 have potential as oral medicines for the treatment of COPD.