Anatomical Characteristics Contributing to Patellar Dislocations Following MPFL Reconstruction: A Dynamic Simulation Study.

Pathologic anatomy is a primary factor contributing to redislocation of the patella following reconstruction of the medial patellofemoral ligament (MPFL). A pivot landing was simulated following MPFL reconstruction, with the hypothesis that position of the tibial tuberosity, depth of the trochlear groove, and height of the patella are correlated with lateral patellar maltracking. Thirteen dynamic simulation models represented subjects being treated for recurrent patellar instability. Simplified Hertzian contact governed patellofemoral and tibiofemoral joint reaction forces. Pivot landing was represented with and without an MPFL graft in place. Measurements related to patellar height (Caton-Deschamps index), trochlear groove depth (lateral trochlear inclination), and position of the tibial tuberosity (lateral tibial tuberosity to posterior cruciate attachment distance, or lateral TT-PCL distance) were measured from the models and correlated with patellar lateral shift with the knee extended (5 deg of flexion) and flexed (40 deg). The patella dislocated for all models without an MPFL graft and for two models with a graft represented. With an MPFL graft represented, patellar lateral shift was correlated with Caton-Deschamps index (r2 > 0.35, p < 0.03) and lateral trochlear inclination (r2 ≥ 0.45, p < 0.02) at both 5 deg and 40 deg of flexion. For a simulated pivot landing with an MPFL graft in place, lateral patellar tracking was associated with a high patella (alta) and shallow trochlear groove. The study emphasizes the importance of simulating activities that place the patella at risk of dislocation when evaluating patellar stability.

Allowing one quadrant of patellar lateral translation during medial patellofemoral ligament reconstruction successfully limits maltracking without overconstraining the patella.

PURPOSE: Graft tensioning during medial patellofemoral ligament (MPFL) reconstruction typically allows for lateral patellar translation within the trochlear groove. Computational simulation was performed to relate the allowed patellar translation to patellofemoral kinematics and contact pressures. METHODS: Multibody dynamic simulation models were developed to represent nine knees with patellar instability. Dual limb squatting was simulated representing the pre-operative condition and simulated MPFL reconstruction. The graft was tensioned to allow 10, 5, and 0 mm of patellar lateral translation at 30° of knee flexion. The patellofemoral contact pressure distribution was quantified using discrete element analysis. RESULTS: For the 5 and 10 mm conditions, patellar lateral shift decreased significantly at 0° and 20°. The 0 mm condition significantly decreased lateral shift for nearly all flexion angles. All graft conditions significantly decreased lateral tilt at 0°, with additional significant decreases for the 5 and 0 mm conditions. The 0 mm condition significantly increased the maximum medial pressure at multiple flexion angles, increasing by 57% at 30°, but did not alter the maximum lateral pressure. CONCLUSIONS: Allowing 5 to 10 mm of patellar lateral translation limits lateral maltracking, thereby decreasing the risk of post-operative recurrent instability. Allowing no patellar translation during graft tensioning reduces maltracking further, but can overconstrain the patella, increasing the pressure applied to medial patellar cartilage already fibrillated or eroded from an instability episode.

Suture spanning augmentation of single-row rotator cuff repair: a biomechanical analysis.

BACKGROUND: This in vitro study evaluated the biomechanical benefit of adding spanning sutures to single-row rotator cuff repair. METHODS: Mechanical testing was performed to evaluate 9 pairs of cadaveric shoulders with complete rotator cuff repairs, with a single-row technique used on one side and the suture spanning technique on the other. The spanning technique included sutures from 2 lateral anchors securing tendon near the musculotendinous junction, spanning the same anchor placement from single-row repair. The supraspinatus muscle was loaded to 100 N at 0.25 Hz for 100 cycles, followed by a ramp to failure. Markers and a video tracking system measured anterior and posterior gap formation across the repair at 25-cycle intervals. The force at which the stiffness decreased by 50% and 75% was determined. Data were compared using paired t-tests. RESULTS: One single-row repair failed at <25 cycles. Both anterior and posterior gap distances tended to be 1 to 2 mm larger for the single-row repairs than for the suture spanning technique. The difference was statistically significant at all cycles for the posterior gap formation (P ≤ .02). The trends were not significant for the anterior gap (P ≥ .13). The loads at which the stiffness decreased by 50% and 75% did not differ significantly between the 2 types of repair (P ≥ .10). CONCLUSIONS: The suture spanning technique primarily improved posterior gap formation. Decreased posterior gap formation could reduce failure rates for rotator cuff repair.

The Capillary Index Score as a Marker of Viable Cerebral Tissue: Proof of Concept-The Capillary Index Score in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Trial.

BACKGROUND AND PURPOSE: The capillary index score (CIS) is based on the hypothesis that areas lacking capillary blush on pretreatment cerebral digital subtraction angiograms correspond to nonviable cerebral tissue. METHODS: Pretreatment digital subtraction angiograms and post-treatment noncontrast enhanced computed tomographic scans from the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) trial were evaluated for areas lacking capillary blush and with tissue hypodensity, respectively. Because the superior and middle zones of the CIS correspond to the 7 cerebral cortex regions of the Alberta Stroke Program Early CT (ASPECT) score, capillary blush was scored in these 2 zones (0-2), called sub-CIS, and compared with the ASPECT score in these 7 regions (0-7), called hypodensity score. The presence and extent of hypodensity were compared between sub-CIS zones with contingency tables and nonparametric comparisons between groups, respectively. RESULTS: On the basis of a sample size of 50 subjects, 100% with sub-CIS <2 had the presence of hypodensity (hypodensity score ≥1) versus 57% for sub-CIS=2 (P=0.004). The extent of hypodensity (numeric hypodensity score) was significantly lower for sub-CIS=2 than 0 or 1 (P=0.02). For 42 subjects with revascularization data, the presence and extent of hypodensity were significantly lower for sub-CIS=2 plus good revascularization than for other combinations of sub-CIS and revascularization (P=0.02 and 0.01, respectively). CONCLUSIONS: The absence of capillary blush on pretreatment digital subtraction angiogram seems to correspond to nonviable cerebral tissue. Successful revascularization reduces the chance of tissue hypodensity (infarction), when capillary blush is present. CLINICAL TRIAL REGISTRATION: URL: http://www.trialregister.nl. Unique identifier: NTR number 1804. URL: http://www.isrctn.com. Unique identifier: ISRCTN10888758.

The Relationship Between Tibial Tuberosity-Trochlear Groove Distance and Abnormal Patellar Tracking in Patients With Unilateral Patellar Instability.

PURPOSE: To evaluate the role of tibial tuberosity-trochlear groove (TT-TG) distance in patellofemoral kinematics by retrospectively reviewing the dynamic computed tomography scans of patients with unilateral patellofemoral instability and comparing unstable and contralateral asymptomatic knees. METHODS: We reviewed all dynamic computed tomography scans obtained at one tertiary care hospital from 2008 through 2013 and identified 25 patients with a history of recurrent unilateral patellofemoral instability. During the scans, subjects performed active knee extension against gravity. Both knees were imaged simultaneously. Lateral patellar tilt (LPT) and bisect offset (BO) were measured to assess tracking. TT-TG distance was measured to assess alignment. Measurements were made in full extension, maximum flexion, and approximately 10° increments in between. The significance level was set at P < .05. RESULTS: LPT, BO, and TT-TG distance were highest in extension and decreased with flexion. Measurements were higher in symptomatic than in asymptomatic knees, with significant differences identified for LPT, BO, and TT-TG distance at 5° and 15° and for TT-TG distance at 25° and 35° (P < .05). TT-TG distance was associated with LPT and BO, with r(2) values in symptomatic knees of 0.55 for TT-TG distance and LPT and of 0.45 for TT-TG distance and BO. CONCLUSIONS: In patients with unilateral patellar instability, LPT, BO, and TT-TG distance are higher on the unstable side. An association exists between TT-TG distance and the tracking parameters studied, suggesting that TT-TG distance relates to patellar tracking, and a laterally positioned tibial tuberosity may predispose to instability episodes. LEVEL OF EVIDENCE: Level IV, diagnostic study.

Characterization of patellar maltracking using dynamic kinematic CT imaging in patients with patellar instability.

PURPOSE: Little has been reported on the relationship between patellar maltracking and instability. Patellar maltracking has been subjectively described with the "J sign" but is difficult to assess objectively using traditional imaging. Dynamic kinematic computed tomography (DKCT) allows dynamic assessment of the patellofemoral joint. DKCT was used to visualize and quantify patellar maltracking patterns, and severity of maltracking was correlated with the presence or absence of patellar instability symptoms. METHODS: Seventy-six knees in 38 patients were analysed using DKCT. Maltracking was defined as deviation of the patella from the trajectory of the trochlear groove and was characterized by patellar bisect offset, which was measured at 10° intervals of knee flexion during active flexion and extension. Bisect offset measurements were grouped by number of quadrants of maximum lateral patellar motion, with one, two, and three quadrants corresponding to 75-99, 100-125, and >125 %, respectively. Patellar instability symptoms were correlated with maltracking severity. RESULTS: Two knees were excluded because of poor imaging quality. Fifty of 74 knees had patellar instability, and 13 patients had bilateral symptoms. Of these, four (8 %) had normal tracking patterns; 41 (82 %) had increased lateral translation in extension, which we termed the J-sign pattern; 4 (8 %) had persistent lateralization of the patella throughout range of motion; and 1 had increased lateral translation in flexion. In knees with the J-sign pattern, degree of maltracking was graded by severity: J1 (n = 24), J2 (n = 19), and J3 (n = 15). The sensitivities of J-sign grades in predicting patellar instability symptoms were 50 % (J1), 80 % (J2), and 93 % (J3) (p < 0.01). There were significant differences in sensitivity between knees with no J sign or J1 versus J2 or J3 (p = 0.02). CONCLUSION: DKCT showed several patellar maltracking patterns in patients with patellar instability. A J-sign pattern with more than two quadrants of lateral translation correlated with the presence of patellar instability symptoms. Incorporation of this approach of objectively quantifying maltracking patterns is recommended in the evaluation of patellofemoral instability. LEVEL OF EVIDENCE: IV.

Relative Influence of Capillary Index Score, Revascularization, and Time on Stroke Outcomes From the Interventional Management of Stroke III Trial.

BACKGROUND AND PURPOSE: Until recently, acute ischemic stroke (AIS) trials have failed to show a benefit of endovascular therapy compared with standard therapy, leading some authors to recommend decreasing the time from ictus to revascularization to improve outcomes. We hypothesize that improving patient selection using the capillary index score (CIS) may also be a useful strategy. METHODS: CIS was calculated, blinded to outcome, from pretreatment diagnostic cerebral angiograms for 78 subjects in the Interventional Management of Stroke III database with internal carotid artery and middle cerebral artery trunk occlusion. The CIS was dichotomized into favorable (fCIS=2 or 3) and poor (pCIS=0 or 1). Outcomes were categorized based on the modified Rankin Scale score at 90 days (0-2 considered a good outcome). Modified thrombolysis in cerebral infarction score 2b or 3 was considered good revascularization. Multivariable logistic regression was performed to relate CIS, time from ictus to revascularization, modified thrombolysis in cerebral infarction score, and National Institue of Health Stroke Scale score to good outcomes. RESULTS: Only CIS and modified thrombolysis in cerebral infarction scores were correlated with good outcomes (P<0.01). Patients with fCIS and good revascularization achieved 71% modified Rankin Scale≤2, compared with 13% for patients with pCIS and good revascularization. CONCLUSIONS: In this subset of patients from the Interventional Management of Stroke III Trial, CIS and modified thrombolysis in cerebral infarction were strong predictors of outcome after endovascular reperfusion. Using the CIS to improve patient selection could be a powerful strategy to improve rate of good outcomes in endovascular therapy. A randomized trial is needed. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00359424.

Correlation Between Changes in Tibial Tuberosity-Trochlear Groove Distance and Patellar Position During Active Knee Extension on Dynamic Kinematic Computed Tomographic Imaging.

PURPOSE: The purpose of this study was to evaluate changes in tibial tuberosity-trochlear groove (TTTG) distance with knee flexion in patients with patellar instability and correlate it with patellar position. METHODS: Patients with symptomatic patellar instability underwent dynamic kinematic computed tomography (CT) during a cycle of knee extension from flexion. Knee flexion angles and corresponding TTTG distances, bisect offset, and patellar tilt were measured. Of the 51 knees, 37 had data available for interpolation between 5° and 30°. Results were interpolated to standardized intervals between 5° and 30° of knee flexion. Repeated-measures analysis (to identify differences between TTTG measurements at various knee flexion angles) and linear regression models (to assess for correlations between TTTG distance and bisect offset and between TTTG distance and patellar tilt) were used. RESULTS: Fifty-one symptomatic knees in 38 patients were available for analysis. Bisect offset and patellar tilt correlated significantly (P < .001) with TTTG distance over all flexion angles. Interpolated results for comparison resulted in 37 knees in which the mean TTTG distance of 17.2 ± 5.8 mm at 5° decreased to 15.5 ± 5.7, 13.0 ± 5.5, and 11.5 ± 4.9 mm at 10°, 20°, and 30° of knee flexion, respectively. Mean TTTG at 5° was 1.5 times greater than that at 30° (P < .001). At 5°, 70.3% (26 of 37) of knees had a TTTG distance of more than 15 mm; at 30°, only 24.3% (9 of 37) exceeded this threshold. CONCLUSIONS: Knee flexion angle during imaging is a critical factor when measuring TTTG distance to evaluate patellofemoral instability. We found that the mean TTTG distance varied by 5.7 mm between 5° and 30° of flexion in patients with symptomatic instability, although this relationship was not completely linear. Bisect offset and patellar tilt measurements mirrored this pattern, suggesting that TTTG distance influences patellar tracking in these patients. LEVEL OF EVIDENCE: Level IV, prognostic case series.

Capillary Index Score in the Interventional Management of Stroke trials I and II.

BACKGROUND AND PURPOSE: The Capillary Index Score (CIS) is a simple angiography-based scale for assessing viable tissue in the ischemic territory. We retrospectively applied it to Interventional Management of Stroke (IMS) trials I and II to evaluate the predictive value for good outcomes. METHODS: CIS was calculated from pretreatment diagnostic cerebral angiograms blinded to outcome. IMS I and II diagnostic cerebral angiogram images of sufficient quality were reviewed and CIS calculated for treated subjects with internal carotid artery or M1 occlusion. CIS scoring (0-3) was dichotomized into favorable (f CIS; 2 or 3) and poor (p CIS; 0 or 1). Modified thrombolysis in cerebral infarction score 2b or 3 was considered good revascularization. CIS and modified thrombolysis in cerebral infarction scores were compared with good outcome, defined as modified Rankin Scale score≤2 at 90 days. RESULTS: Twenty-eight of 161 subjects met the inclusion criteria. Thirteen (46%) had f CIS. Good clinical outcome was significantly different between the 2 CIS groups (62% for f CIS versus 7% for p CIS; P=0.004). Good reperfusion correlated to good outcome (P=0.04). No significant differences in time to intravenous or intra-arterial treatment were identified between f CIS and p CIS groups (P>0.25). CONCLUSIONS: A f CIS was found in ≈50% of subjects and was a virtual prerequisite for good outcome in this study subgroup of IMS I and II. We call this the 50% barrier.

Imaging characteristics of contralateral asymptomatic patellofemoral joints in patients with unilateral instability.

PURPOSE: To test the hypothesis that in patients with unilateral patellofemoral instability ( PI patellofemoral instability ), the contralateral asymptomatic joints have abnormal morphology and imaging features of osteoarthritis ( OA osteoarthritis ) at four-dimensional ( 4D four-dimensional ) computed tomography (CT). MATERIALS AND METHODS: The institutional review board approved this HIPAA-compliant retrospective study. Informed consent was waived. Radiology records were reviewed to identify 25 patients (male-female ratio, 0.56; median age, 20 years; range, 13-43 years) with unilateral PI patellofemoral instability undergoing 4D four-dimensional CT and 25 age- and sex-matched control patients undergoing multidetector CT. Trochlear groove depth ( TGD trochlear groove depth ), tibial tuberosity-trochlear groove ( TT-TG tibial tuberosity-trochlear groove ) distance, and patellar height ratio ( PHR patellar height ratio ) were determined to compare morphology, and bisect offset ( BO bisect offset ) measurements were obtained to compare lateral displacement of the patella between the two groups by using the Wilcoxon rank-sum test. All images were interpreted by trained observers. Tracking patterns of the patellae were determined by obtaining BO bisect offset measurements at various flexion angles with 4D four-dimensional CT. RESULTS: In the contralateral asymptomatic joints, TGD trochlear groove depth (median, 3.0 mm; 95% confidence interval [ CI confidence interval ]: 2.5, 4.6; P < .0001), TT-TG tibial tuberosity-trochlear groove (median, 15 mm; 95% CI confidence interval : 12.7, 18; P = .008), PHR patellar height ratio (median, 1.17; 95% CI confidence interval : 1.09, 1.2; P = .002), and patellar lateral displacement ( BO bisect offset , 85%; 95% CI confidence interval : 76.2%, 98.2%; P < .0001) were different from measurements obtained in the control group: TGD trochlear groove depth median, 5.0 mm (95% CI confidence interval : 2.2, 7.6); TT-TG tibial tuberosity-trochlear groove median, 10.9 mm (95% CI confidence interval : 3.4, 20.7); PHR patellar height ratio median, 0.92 (95% CI confidence interval : 0.67, 1.36); and BO bisect offset median, 63% (95% CI confidence interval : 59%, 68.4%). OA osteoarthritis was detected in 40% of asymmetrical contralateral joints (10 of 25). By using 4D four-dimensional CT data, multiple regression analysis demonstrated that TGD trochlear groove depth (P = .026) and BO bisect offset measurements obtained at 30° of knee flexion (P = .047) had an association with the presence of OA osteoarthritis . CONCLUSION: Abnormal morphology and imaging features of OA osteoarthritis are relatively common in contralateral asymptomatic joints of young patients with unilateral PI patellofemoral instability .

Variations in kinematics and function following patellar stabilization including tibial tuberosity realignment.

PURPOSE: The current study was performed to characterize the influence of patellar stabilization procedures on patellofemoral and tibiofemoral dynamic motion. METHODS: Six knees were evaluated pre-operatively and 1 year or longer following stabilization via tibial tuberosity realignment, with simultaneous medial patellofemoral ligament reconstruction performed for five knees. Knees were imaged during extension against gravity using a dynamic CT scanner. Models representing each knee at several positions of extension were reconstructed from the images. Local coordinate systems were created within one femur, patella and tibia for each knee, with shape matching of the bones used to transfer the coordinate axes to the other models. The patellar lateral shift and tilt and tibial external rotation were quantified based on the reference axes and interpolated to flexion angles from 5° to 40°. Pre-operative and post-operative data were compared with the paired t tests. RESULTS: Surgical realignment significantly decreased the average patellar lateral shift and tilt at low flexion angles. At 5°, surgical realignment decreased the average lateral shift from 15.5 (6.3) to 8.5 (4.7) mm and decreased the average lateral tilt from 20.8 (9.4)° to 13.8 (6.4)°. The changes were statistically significant (p<0.05) at 5° and 10° of flexion, as well as 20° for lateral shift. The average tibial external rotation also increased significantly at 30° and 40° following surgery. CONCLUSION: Patellar stabilization including a component of tuberosity realignment reduces patellar lateral shift and tilt at low flexion angles, but the long-term influence of increased tibial external rotation on tibiofemoral function is currently unknown. LEVEL OF EVIDENCE: Prospective comparative study, Level II.

Anatomical factors influencing patellar tracking in the unstable patellofemoral joint.

PURPOSE: The current study was performed to relate anatomical parameters to in vivo patellar tracking for pediatric patients with recurrent patellar instability. METHODS: Seven pediatric patients with recurrent patellar instability that failed conservative treatment were evaluated using computational reconstruction of in vivo patellofemoral function. Computational models were created from high-resolution MRI scans of the unloaded knee and lower-resolution scans during isometric knee extension at multiple flexion angles. Shape matching techniques were applied to replace the low-resolution models of the loaded knee with the high-resolution models. Patellar tracking was characterized by the bisect offset index (lateral shift) and lateral tilt. Anatomical parameters were characterized by the inclination of the lateral ridge of the trochlear groove, the tibial tuberosity-trochlear groove distance, the Insall-Salvati index and the Caton-Deschamps index. Stepwise multivariable linear regression analysis was used to relate patellar tracking to the anatomical parameters. RESULTS: The bisect offset index and lateral tilt were significantly correlated with the lateral trochlear inclination (p≤0.002) and TT-TG distance (p<0.05), but not the Insall-Salvati index or the Caton-Deschamps index. For both the bisect offset index and lateral tilt, the standardized beta coefficient, used to identify the best anatomical predictors of tracking, was larger for the lateral trochlear inclination than the TT-TG distance. CONCLUSION: For this population, the strongest predictor of lateral maltracking that could lead to patellar instability was lateral trochlear inclination. LEVEL OF EVIDENCE: Diagnostic study, Level II.

Influence of medial patellofemoral ligament reconstruction on patellar tracking and patellofemoral contact pressures in patella alta.

Knee squatting was simulated to characterize the influence of medial patellofemoral ligament (MPFL) reconstruction on patellar tracking and contact pressures for knees with mild patella alta (Caton-Deschamps index = 1.3-1.4). Eight computational models represented knees in the pre-operative condition and following MPFL reconstruction. MPFL reconstruction significantly reduced patellar lateral tracking at low flexion angles based on bisect offset index, significantly decreased the maximum lateral pressure in mid-flexion, and significantly increased the maximum medial pressure in mid-flexion. MPFL reconstruction improves patellar stability for knees with mild patella alta and can reduce the pressure applied to lateral cartilage on the patella.

Biomechanical comparison of composite and cadaveric humeri models in experiments on operated humeral shaft fractures.

A study was undertaken to determine how well contacting fracture fragments of composite bone replicated the behavior of fracture fragments in real bone. Ten composite and ten real humeral diaphyses were transected and reconstructed with limited-contact dynamic-compression plates. Two screws were placed on each side of the transection site and a calibrated electronic sensor sheet was placed between the imitated fracture fragments. After insertion of the distal screws, pressure measurements were made during insertion of the first proximal screw in compression mode, during insertion of the second screw in compression mode after loosening the first screw, and finally after retightening the first screw. The process was repeated after bending the plate. The contact area, the net compression force and the average compressive stress were computed and statistically compared. The composite bone and cadaveric bone differed in contact area and compressive stress but not in net compressive force. Plate bending did not produce a significant difference between composite and cadaveric bone. The results indicate that composite bone does not reproduce all the local fracture fragment conditions so that hardware testing in composite bone should proceed carefully. A gap between fracture fragments as is often used in comminuted fracture tests may remain as the most appropriate situation for fracture hardware testing.

Evaluation of Differences in Patellar Height After Patellar Stabilization Procedures Not Intended to Address Patella Alta: A Multicenter Study.

Background: Recent studies have reported conflicting results as to whether isolated medial patellofemoral ligament reconstruction (MPFLr) leads to decreased patellar height. Purpose: To investigate if patellar stabilization surgery not intended to address patella alta influences patellar height. Study Design: Cohort study; Level of evidence, 3. Methods: A multicenter retrospective chart review was conducted, and patients who underwent MPFLr, medializing tibial tuberosity osteotomy (TTO), and/or trochleoplasty between 2016 and 2020 were included. The Caton-Deschamps index (CDI) was calculated from radiographs obtained preoperatively, 2 weeks postoperatively, and 3 months postoperatively. The preoperative CDI value was compared with the 2-week postoperative and 3-month postoperative values according to stabilization procedure (isolated MPFLr, isolated TTO, MPFLr + TTO, MPFLr + trochleoplasty, and MPFLr + trochleoplasty + TTO) using the paired t test. Analyses of the 1-bundle versus 2-bundle MPFLr technique and the presence of lateral retinacular release or lateral retinacular lengthening were conducted on the isolated MPFLr and combined MPFLr + TTO cohorts. Results: A total of 356 knees were included. Statistically significant pre- to postoperative decreases in CDI were seen in all stabilization procedures analyzed (P≤ .017 for all). Within the isolated MPFLr cohort, this significant decrease was seen at 2 weeks postoperatively with the 2-bundle technique (ΔCDI = -0.09; P < .001) but not with the 1-bundle technique (ΔCDI = -0.01; P = .621). Conclusion: The different surgical techniques analyzed in the current study affected patellar height, even when a distalizing TTO was not performed. The decrease was dependent on surgical technique, with a 2-bundle MPFLr leading to a statistically significant decrease and a 1-bundle MPFLr effecting no change.

Discrete element analysis for characterizing the patellofemoral pressure distribution: model evaluation.

The current study was performed to evaluate the accuracy of computational assessment of the influence of the orientation of the patellar tendon on the patellofemoral pressure distribution. Computational models were created to represent eight knees previously tested at 40 deg, 60 deg, and 80 deg of flexion to evaluate the influence of hamstrings loading on the patellofemoral pressure distribution. Hamstrings loading increased the lateral and posterior orientation of the patellar tendon, with the change for each test determined from experimentally measured variations in tibiofemoral alignment. The patellar tendon and the cartilage on the femur and patella were represented with springs. After loading the quadriceps, the total potential energy was minimized to determine the force within the patellar tendon. The forces applied by the quadriceps and patellar tendon produced patellar translation and rotation. The deformation of each cartilage spring was determined from overlap of the cartilage surfaces on the femur and patella and related to force using linear elastic theory. The patella was iteratively adjusted until the extension moment, tilt moment, compression, and lateral force acting on the patella were in equilibrium. For the maximum pressure applied to lateral cartilage and the ratio of the lateral compression to the total compression, paired t-tests were performed at each flexion angle to determine if the output varied significantly (p < 0.05) between the two loading conditions. For both the computational and experimental data, loading the hamstrings significantly increased the lateral force ratio and the maximum lateral pressure at multiple flexion angles. For the computational data, loading the hamstrings increased the average lateral force ratio and maximum lateral pressure by approximately 0.04 and 0.3 MPa, respectively, compared to experimental increases of 0.06 and 0.4 MPa, respectively. The computational modeling technique accurately characterized variations in the patellofemoral pressure distribution caused by altering the orientation of the patellar tendon.

Adding Tibial Tuberosity Medialization to Medial Patellofemoral Ligament Reconstruction Reduces Lateral Patellar Maltracking During Multidirectional Motion in a Computational Simulation Model.

Purpose: To determine whether adding tibial tuberosity medialization to medial patellofemoral ligament (MPFL) reconstruction reduces lateral patellar maltracking during a dynamic multidirectional activity and to investigate when medial patellofemoral contact pressures are elevated during daily activities, such as squatting. Methods: Seven computational models representing knees with patellar instability, including lateral patellar maltracking, were evaluated following simulated MPFL reconstruction (bisect offset index > .75). Tibial tuberosity medialization was added to MPFL reconstruction for each model. Patellar tracking during multidirectional motion was evaluated by simulating pivot landing. Analysis of pivoting focused on early flexion (5° to 40°). Patellofemoral contact pressures during daily function were evaluated by simulating knee squatting. Data were analyzed with paired comparisons between MPFL reconstruction with and without tuberosity medialization. Results: The patella dislocated during pivoting for 2 models with an isolated MPFL reconstruction and for 1 model including tibial tuberosity medialization. Adding tibial tuberosity medialization to MPFL reconstruction significantly decreased bisect offset index by ∼0.1 from 5° to 40° (P < .03). For knee squatting, medializing the tibial tuberosity significantly increased maximum medial contract pressure by ∼0.5 MPa from 30° to 85° (P < .05) but did not significantly influence maximum lateral pressure. Conclusions: In this study of simulated multidirectional motion, MPFL reconstruction did not sufficiently constrain the patella for some knees. Adding tibial tuberosity medialization to MPFL reconstruction in these models reduced lateral patellar maltracking during multidirectional motion but increased pressure applied to medial cartilage during squatting. Clinical Relevance: After establishing the influence of tibial tuberosity medialization on patellar maltracking for an idealized population, as was done in the current study, future simulation studies can be performed to better determine the anatomical characteristics of patients for whom tibial tuberosity medialization is needed to reduce the risk of postoperative patellar maltracking.

Quantitative MRI for Evaluation of Musculoskeletal Disease: Cartilage and Muscle Composition, Joint Inflammation, and Biomechanics in Osteoarthritis.

ABSTRACT: Magnetic resonance imaging (MRI) is a valuable tool for evaluating musculoskeletal disease as it offers a range of image contrasts that are sensitive to underlying tissue biochemical composition and microstructure. Although MRI has the ability to provide high-resolution, information-rich images suitable for musculoskeletal applications, most MRI utilization remains in qualitative evaluation. Quantitative MRI (qMRI) provides additional value beyond qualitative assessment via objective metrics that can support disease characterization, disease progression monitoring, or therapy response. In this review, musculoskeletal qMRI techniques are summarized with a focus on techniques developed for osteoarthritis evaluation. Cartilage compositional MRI methods are described with a detailed discussion on relaxometric mapping (T 2 , T 2 *, T 1ρ ) without contrast agents. Methods to assess inflammation are described, including perfusion imaging, volume and signal changes, contrast-enhanced T 1 mapping, and semiquantitative scoring systems. Quantitative characterization of structure and function by bone shape modeling and joint kinematics are described. Muscle evaluation by qMRI is discussed, including size (area, volume), relaxometric mapping (T 1 , T 2 , T 1ρ ), fat fraction quantification, diffusion imaging, and metabolic assessment by 31 P-MR and creatine chemical exchange saturation transfer. Other notable technologies to support qMRI in musculoskeletal evaluation are described, including magnetic resonance fingerprinting, ultrashort echo time imaging, ultrahigh-field MRI, and hybrid MRI-positron emission tomography. Challenges for adopting and using qMRI in musculoskeletal evaluation are discussed, including the need for metal artifact suppression and qMRI standardization.

Patellar Dislocation in Adolescent Patients: Influence on Cartilage Properties Based on T1ρ Relaxation Times.

BACKGROUND: Adolescents who experience a patellar dislocation have an elevated risk of patellofemoral posttraumatic osteoarthritis. Magnetic resonance imaging (MRI)-based T1ρ relaxation times were measured for adolescents to evaluate patellofemoral cartilage after patellar dislocation. Long T1ρ relaxation times are an indicator of cartilage degradation. HYPOTHESIS: The primary hypothesis is that patellofemoral cartilage T1ρ relaxation times will be elevated in the acute phase after patellar dislocation. The secondary hypothesis is that T1ρ relaxation times will be higher for knees with multiple rather than single dislocations due to repeated traumatic injury. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: In total, 23 adolescents being treated for a recent patellar dislocation, 13 for a first-time dislocation (47 ± 38 days since most recent dislocation) and 10 for multiple dislocations (55 ± 24 days since most recent dislocation), and 10 healthy controls participated in MRI-based T1ρ relaxation time mapping. For multiple regions of the patellofemoral joint, mean T1ρ values were compared between the 3 groups with multiple group comparisons and post hoc tests. T1ρ relaxation times were also correlated against measures of patellofemoral anatomy and alignment for single and multiple dislocations. Statistical significance was set at P < .05. RESULTS: T1ρ relaxation times were significantly longer for injured knees (single and multiple dislocations) than controls at the medial and central patella and central trochlear groove. For the regions on the patella, significant differences between injured and control knees exceeded 15%. No significant differences were identified between single and multiple dislocations. For the initial dislocation group, T1ρ relaxation times within multiple regions of the patellofemoral joint were significantly correlated with lateral patellar alignment or patellar height. CONCLUSION: Elevated patellofemoral cartilage T1ρ relaxation times are consistent with a high risk of long-term patellofemoral osteoarthritis for adolescents who experience patellar dislocations. T1ρ relaxation times were elevated for multiple regions of patellofemoral cartilage. T1ρ relaxation times were expected to increase with additional dislocation episodes, but relaxation times after single and multiple dislocations were similar. After a first dislocation, parameters related to patellar maltracking were correlated with cartilage degradation.

The effect of tibial tuberosity realignment procedures on the patellofemoral pressure distribution.

PURPOSE: The study was performed to characterize the influence of tibial tuberosity realignment on the pressure applied to cartilage on the patella in the intact condition and with lesions on the lateral and medial facets. METHODS: Ten knees were loaded in vitro through the quadriceps (586 N) and hamstrings (200 N) at 40°, 60°, and 80° of flexion while measuring patellofemoral contact pressures with a pressure sensor. The tibial tuberosity was positioned 5 mm lateral of the normal position to represent lateral malalignment, 5 mm medial of the normal position to represent tuberosity medialization, and 10 mm anterior of the medial position to represent tuberosity anteromedialization. The knees were tested with intact cartilage, with a 12-mm-diameter lesion created within the lateral patellar cartilage, and with the lateral lesion repaired with silicone combined with a medial lesion. A repeated measures ANOVA and post hoc tests were used to identify significant (P < 0.05) differences in the maximum lateral and medial pressure between the tuberosity positions. RESULTS: Tuberosity medialization and anteromedialization significantly decreased the maximum lateral pressure by approximately 15% at 60° and 80° for intact cartilage and cartilage with a lateral lesion. Tuberosity medialization significantly increased the maximum medial pressure for intact cartilage at 80°, but the maximum medial pressure did not exceed the maximum lateral pressure for any testing condition. CONCLUSIONS: The results indicate that medializing the tibial tuberosity by 10 mm reduces the pressure applied to lateral patellar cartilage for intact cartilage and cartilage with lateral lesions, but does not overload medial cartilage.