1.
Br J Haematol
; 2024 May 23.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38783629
RESUMEN
Acute chest syndrome (ACS) is a leading cause of morbimortality in sickle cell disease (SCD). In this prospective observational study, we investigated sputum interleukin-6 (IL-6) level as an ACS severity marker during 30 ACS episodes in 26 SCD children. Sputum IL-6 levels measured within the first 72 h of hospitalisation for ACS were significantly higher in patients with oxygen requirement ≥2 L/min, ventilation (invasive and/or non-invasive) length ≥5 days, bilateral and/or extensive opacities on chest X-ray or erythrocytapheresis requirement. Sputum IL-6 could serve as an ACS severity marker to help identify patients requiring targeted anti-inflammatory treatments such as tocilizumab.
2.
Am J Hematol
; 98(7): E175-E178, 2023 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37096490
Asunto(s)
Síndrome Torácico Agudo , Anemia de Células Falciformes , Hemoglobinopatías , Humanos , Niño , Interleucina-6 , Pronóstico , Estudios Prospectivos , Esputo
3.
Am J Hematol
; 97(3): E81-E83, 2022 03 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34874576