RESUMEN
BACKGROUND: Dermatologists play an important role in diagnosing and managing hospitalized patients with cutaneous abnormalities. Skin biopsies remain an indispensable tool for aiding dermatologists in accurate diagnosis and treatment. We aimed to determine the range of conditions, and the most common conditions, prompting skin biopsy by dermatology hospital consultation (HCON) services to aid in evaluation of hospitalized patients. METHODS: All hospitalized patients seen by a single tertiary care center dermatology HCON service between 2015 and 2018 who had associated skin biopsies were identified. Histologic features and clinical diagnoses of each patient were classified into 13 histologic reaction pattern categories. RESULTS: Eight hundred and thirty one inpatients evaluated by our dermatology HCON service had 914 skin biopsies. The most frequent diagnostic categories prompting biopsy were vasculopathic (17.6%), interface dermatitis (16.5%), infectious (12.6%), and spongiotic dermatitis (10.9%). The most frequent diagnostic categories included drug reaction (13.2%), leukocytoclastic vasculitis (8.5%), skin cancer (5.4%), graft-vs-host disease (3.5%), connective tissue disease (3.3%), and calciphylaxis (3.0%). CONCLUSION: Our study suggests a variety of serious diseases affecting inpatients prompts biopsy by dermatology consultation services. Educational curricula for dermatology and pathology residents, fellows, and staff designed with these data may enhance knowledge that improves the quality of inpatient dermatology care.
Asunto(s)
Enfermedades de la Piel/diagnóstico , Enfermedades de la Piel/patología , Piel/patología , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Dermatólogos , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Derivación y Consulta , Estudios Retrospectivos , Enfermedades de la Piel/clasificación , Centros de Atención Terciaria , Adulto JovenAsunto(s)
Metotrexato/uso terapéutico , Neumonía por Pneumocystis/prevención & control , Combinación Trimetoprim y Sulfametoxazol/efectos adversos , Adulto , Enfermedades Autoinmunes/tratamiento farmacológico , Contraindicaciones de los Medicamentos , Quimioterapia Combinada , Femenino , Humanos , Leucopenia/inducido químicamente , Hígado/efectos de los fármacos , Masculino , Persona de Mediana Edad , Transaminasas/sangre , Combinación Trimetoprim y Sulfametoxazol/uso terapéuticoAsunto(s)
Antígeno Ki-1/análisis , Micosis Fungoide/diagnóstico , Síndrome de Sézary/diagnóstico , Neoplasias Cutáneas/diagnóstico , Anciano , Bexaroteno/administración & dosificación , Humanos , Antígeno Ki-1/metabolismo , Masculino , Persona de Mediana Edad , Micosis Fungoide/sangre , Micosis Fungoide/tratamiento farmacológico , Micosis Fungoide/patología , Fotoféresis , Síndrome de Sézary/sangre , Síndrome de Sézary/tratamiento farmacológico , Síndrome de Sézary/patología , Neoplasias Cutáneas/sangre , Neoplasias Cutáneas/tratamiento farmacológico , Neoplasias Cutáneas/patología , Linfocitos T/metabolismo , Resultado del Tratamiento , Vorinostat/administración & dosificaciónAsunto(s)
Productos Biológicos/efectos adversos , Hidradenitis Supurativa/tratamiento farmacológico , Tuberculosis Latente/epidemiología , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores , Adulto , Femenino , Hidradenitis Supurativa/sangre , Hidradenitis Supurativa/inmunología , Humanos , Incidencia , Ensayos de Liberación de Interferón gamma/estadística & datos numéricos , Tuberculosis Latente/sangre , Tuberculosis Latente/diagnóstico , Tuberculosis Latente/inmunología , Masculino , Persona de Mediana Edad , Seroconversión , Factor de Necrosis Tumoral alfa/inmunologíaRESUMEN
INTRODUCTION: Dermatologic manifestations of diseases in solid organ transplant recipients are common due to long-term immunosuppression. CASE PRESENTATION: We present the case of a 63-year-old man with a kidney transplant who exhibited subcutaneous nodules on lower extremities, cytopenia, and asymptomatic pulmonary infiltrate. Through a skin biopsy and 16S ribosomal RNA (rRNA) sequencing, Mycobacterium haemophilum was identified. His clinical course was complicated by empyema, septic arthritis, and recurrence of his skin manifestations, despite ongoing antimicrobial treatment. DISCUSSION: This case emphasizes the challenges and potential complications associated with M haemophilum infections in solid organ transplant recipients receiving long-term immunosuppressive therapy. It highlights the importance of employing advanced diagnostic techniques when evaluating dermatologic manifestations in these patients. The patient's complex clinical course also underscores the difficulties involved in effectively addressing and managing complications that may arise even after initiating therapy.
Asunto(s)
Trasplante de Riñón , Mycobacterium haemophilum , Humanos , Trasplante de Riñón/efectos adversos , Masculino , Persona de Mediana Edad , Mycobacterium haemophilum/aislamiento & purificación , Infecciones por Mycobacterium/diagnóstico , Infecciones por Mycobacterium/microbiología , Infecciones por Mycobacterium/tratamiento farmacológico , Huésped InmunocomprometidoRESUMEN
This drawing considers how achieving balance between allopathic, Western medical practices and spiritual practices can be critical for clinicians hoping to offer compassionate health care. Ethical and clinical challenges of consistently offering compassionate care to patients from all backgrounds requires cultivating and practicing spiritual awareness while maintaining professional boundaries.