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1.
Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease.
Mol Cell Neurosci
; 114: 103641, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34091073
2.
ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.
Neurobiol Dis
; 161: 105543, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34737044
3.
Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter ß-amyloid levels in the CNS.
J Neurochem
; 132(4): 477-86, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25156639
4.
AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice.
J Neurosci
; 33(24): 10075-84, 2013 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-23761903
5.
Prediction and modeling of effects on the QTc interval for clinical safety margin assessment, based on single-ascending-dose study data with AZD3839.
J Pharmacol Exp Ther
; 350(2): 469-78, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24917547
6.
Population PKPD modeling of BACE1 inhibitor-induced reduction in Aß levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.
Pharm Res
; 31(3): 670-83, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24092053
7.
In brown adipocytes, adrenergically induced ß1-/ß3-(Gs)-, α2-(Gi)- and α1-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation.
Exp Cell Res
; 319(17): 2718-27, 2013 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23948306
8.
Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease.
J Biol Chem
; 287(49): 41245-57, 2012 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-23048024
9.
AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.
J Neurochem
; 125(3): 446-56, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23410232
10.
Aminoimidazoles as BACE-1 inhibitors: the challenge to achieve in vivo brain efficacy.
Bioorg Med Chem Lett
; 22(5): 1854-9, 2012 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22325942
11.
Characterization of monomeric and soluble aggregated Aß in Down's syndrome and Alzheimer's disease brains.
Neurosci Lett
; 754: 135894, 2021 05 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-33848613
12.
Evidence for dimeric BACE-mediated APP processing.
Biochem Biophys Res Commun
; 393(1): 21-7, 2010 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-20097169
13.
How partnership should work to bring innovative medicines to patients.
Drug Discov Today
; 25(6): 965-968, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32173523
14.
Alpha-Synuclein Protofibrils in Cerebrospinal Fluid: A Potential Biomarker for Parkinson's Disease.
J Parkinsons Dis
; 10(4): 1429-1442, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33016895
15.
Differential signalling pathways for EGF versus PDGF activation of Erk1/2 MAP kinase and cell proliferation in brown pre-adipocytes.
Exp Cell Res
; 314(19): 3581-92, 2008 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18838072
16.
AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics.
J Alzheimers Dis
; 50(4): 1109-23, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26890753
17.
Combining an amyloid-beta (Aß) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aß production.
FEBS J
; 282(1): 65-73, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25303711
18.
Population pharmacokinetic and pharmacodynamic analysis of plasma Aß40 and Aß42 following single oral doses of the BACE1 inhibitor AZD3839 to healthy volunteers.
Clin Pharmacol Drug Dev
; 3(5): 396-405, 2014 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27129013
19.
Core refinement toward permeable ß-secretase (BACE-1) inhibitors with low hERG activity.
J Med Chem
; 56(11): 4181-205, 2013 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23126626
20.
New aminoimidazoles as ß-secretase (BACE-1) inhibitors showing amyloid-ß (Aß) lowering in brain.
J Med Chem
; 55(21): 9297-311, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-23017051