[HPV and cervical cancer: knowledge and practices of physicians in Fez]. / Connaissances et pratiques des médecins vis-à-vis du cancer du col de l'utérus et de l'infection HPV à Fès.

INTRODUCTION: The main objective of this paper is to assess the knowledge and practices of primary care physicians related to cervical cancer and HPV infection. METHODOLOGY: A cross-sectional study was conducted in May 2010 among general practitioners in all health centers in the Wilaya of Fez, Morocco. A self-administered questionnaire was used to collect the data. RESULTS: The response rate was 77.7%. Only 25.6% of the physicians reported that they knew how to perform pap smears, while just 7.9% (all women) actually perform Pap smears. The main reasons for not performing Pap smears were lack of training (69.0%) and lack of resources (24.0%). 89.0% of the participants stated that a family history of cervical cancer is a risk factor for cervical cancer, while all the physicians reported that sexually transmitted diseases and having multiple sexual partners are risk factors. 94.9% stated that early age at first sexual intercourse is a risk factor, while 97.4% stated that genital warts are a risk factor. 76.4% stated that they were aware of the existence of the HPV vaccine. CONCLUSION: The results show that physicians have limited knowledge of HPV and cervical cancer and that their participation in cervical cancer screening and diagnosis is also relatively low. We conclude that there is a need for training and increased awareness.

Human cytomegalovirus and isocitrate dehydrogenase status in glioma: association and prognosis value in Moroccan population.

Introduction: Human cytomegalovirus (HCMV) and isocitrate dehydrogenase (IDH) have been separately associated to gliomas. IDH is a molecular marker considered in the histo-molecular classification of gliomas as well as in their management and prognosis. However, even if oncomodulatory properties were attributed to HCMV, its association to gliomas remains a controversy. Most of the studies that investigated this association used the histological classification of gliomas; nevertheless, in 2016, the World Health Organization recommended the introduction of molecular characteristics to refine this classification. The aims of this study were to determine the prevalence of HCMV in glioma patients, the association between HCMV and IDH with gliomas and subsequently their associations with survival of patients in a Moroccan cohort. Methods: A series of 102 gliomas and 32 controls were analyzed by nested PCR (nPCR) to determine the HCMV status. PCR and sequencing were used to determine the IDH subtypes in tumors samples. IDH mutation and HCMV status were correlated to the characteristics of the tumors using SPSS, whereas the survival curves were obtained by the Kaplan-Meier method and the log rank test. Results: HCMV shows significant association with gliomas with a detection rate of 30.4% and no case in the control group. The IDH mutation was identified in 40.9-50% of grade II-III gliomas and in 10.9% of grade IV gliomas. A significant association was obtained between survival in patients with glioblastomas and IDH/HCMV status. Glioblastoma patients with HCMV+ and IDHwt had a poor prognostic. Conclusions: HCMV was detected exclusively in tumor cases and was significantly associated with poor prognosis in patients with gliomas and particularly with glioblastomas. The worst overall survival was significantly seen in patients with gliomas HCMV+/IDHwt. So, it will be of interest to consider HCMV and IDH status in gliomas management strategies.

Prevalence and associated factors of COVID-19 among Moroccan physicians: A cross-sectional study.

BACKGROUND: Coronavirus disease (COVID-19) has emerged and spread rapidly worldwide and established a global public health crisis in early 2020. The first Moroccan case was reported on March 2, 2020. Since then, healthcare workers (HCWs) played a major role in saving human lives threatened by COVID-19. This study aimed to assess the prevalence of COVID-19 infection among Moroccan physicians and to report associated risk factors prior vaccination campaign. METHODS: A cross-sectional study was carried out in the Fez-Meknes region of Morocco, 545 physicians' data was collected using a self-reported online questionnaire. The data collection was done between December 1, 2020, and February 1, 2021. RESULTS: The prevalence of COVID-19 among physicians was 27.3%. The mean age of the confirmed COVID-19 group was 38.4±12.9 years old. There was no association between COVID-19 infection and preventive measures compliance by physicians and healthcare authorities in the workplace. However, multivariate analysis strengthened the following factors such as increased risk of COVID-19 infection within men ☯aOR:1.896; 95% IC 1.272-2.828; p = 0.002]; the presence of at least one comorbidity ☯aOR:2.268; 95%IC 1.414-3.637; p = 0.001]; and working at a university or military hospitals ☯aOR:2.578; 95%IC 1.667-3.989; p = 0.001]. CONCLUSION: This study allows comparing COVID-19 prevalence among healthcare workers before and after vaccination programs. This should support better preparation strategy for any future pandemics with appropriate and increased awareness for men, carrying comorbidity, and working environment with high COVID-19 disease management.

Cross-cultural adaptation and validation of the Moroccan version of the incontinence quality of life questionnaire (I-QoL) in urinary incontinence patients.

OBJECTIVE: Because of the importance and prevalence of incontinence in women, there is growing interest in the development and use of well-designed quality of life questionnaires. The objective of this study is to adapt and validate, the I-QoL, a quality of life questionnaire, in Moroccan dialect, and to assess its psychometric properties in people suffering from urinary incontinence STUDY DESIGN: One hundred patients (77 % female) with a symptom of urinary incontinence participated in the study and filled out the Moroccan version of the questionnaire. The reliability and validity of the questionnaire were assessed by Cronbach's alpha coefficient (α), the intraclass correlation coefficient (ICC), and confirmatory factor analysis. RESULTS: The results showed that the Moroccan version of the I-QOL has very good psychometric properties. The overall I-QoL summary score and subscales showed high internal consistency (alpha ranging from 0.94 to 0.99). Inter-rater reliability was substantial for the three subscales and the total score. The ICC, assessing reproducibility at two weeks, ranged from 0.89 to 0.99, demonstrating the stability of the scores. The I-QOL was able to discriminate between different levels of self- perceived severity. Significant differences in I-QOL scores (p<0.001) were observed when comparing I-QOL scores by the number of incontinence-related medical visits made by patients during the past year. CONCLUSION: The Moroccan version of the I-QOL is a valid and reliable tool to determine the influence of urinary incontinence on health-related quality of life in Moroccan persons.