Image-based computer modeling assessment of microwave ablation for treatment of adrenal tumors.

PURPOSE: To assess the feasibility of delivering microwave ablation for targeted treatment of aldosterone producing adenomas using image-based computational models. METHODS: We curated an anonymized dataset of diagnostic 11C-metomidate PET/CT images of 14 patients with aldosterone producing adenomas (APA). A semi-automated approach was developed to segment the APA, adrenal gland, and adjacent organs within 2 cm of the APA boundary. The segmented volumes were used to implement patient-specific 3D electromagnetic-bioheat transfer models of microwave ablation with a 2.45 GHz directional microwave ablation applicator. Ablation profiles were quantitatively assessed based on the extent of the APA target encompassed by an ablative thermal dose, while limiting thermal damage to the adjacent normal adrenal tissue and sensitive critical structures. RESULTS: Across the 14 patients, adrenal tumor volumes ranged between 393 mm3 and 2,395 mm3. On average, 70% of the adrenal tumor volumes received an ablative thermal dose of 240CEM43, while limiting thermal damage to non-target structures, and thermally sparing 83.5-96.4% of normal adrenal gland. Average ablation duration was 293 s (range: 60-600 s). Simulations indicated coverage of the APA with an ablative dose was limited when the axis of the ablation applicator was not well aligned with the major axis of the targeted APA. CONCLUSIONS: Image-based computational models demonstrate the potential for delivering microwave ablation to APA targets within the adrenal gland, while limiting thermal damage to surrounding non-target structures.

Immediate word recall in cognitive assessment can predict dementia using machine learning techniques.

BACKGROUND: Dementia, one of the fastest-growing public health problems, is a cognitive disorder known to increase in prevalence as age increases. Several approaches had been used to predict dementia, especially in building machine learning (ML) models. However, previous research showed that most models developed had high accuracies, and they suffered from considerably low sensitivities. The authors discovered that the nature and the scope of the data used in this study had not been explored to predict dementia based on cognitive assessment using ML techniques. Therefore, we hypothesized that using word-recall cognitive features could help develop models for the prediction of dementia through ML techniques and emphasized assessing the models' sensitivity performance. METHODS: Nine distinct experiments were conducted to determine which responses from either sample person (SP)'s or proxy's responses in the "word-delay," "tell-words-you-can-recall," and "immediate-word-recall" tasks are essential in the prediction of dementia cases, and to what extent the combination of the SP's or proxy's responses can be helpful in the prediction of dementia. Four ML algorithms (K-nearest neighbors (KNN), decision tree, random forest, and artificial neural networks (ANN)) were used in all the experiments to build predictive models using data from the National Health and Aging Trends Study (NHATS). RESULTS: In the first scenario of experiments using "word-delay" cognitive assessment, the highest sensitivity (0.60) was obtained from combining the responses from both SP and proxies trained KNN, random forest, and ANN models. Also, in the second scenario of experiments using the "tell-words-you-can-recall" cognitive assessment, the highest sensitivity (0.60) was obtained by combining the responses from both SP and proxies trained KNN model. From the third set of experiments performed in this study on the use of "Word-recall" cognitive assessment, it was equally discovered that the use of combined responses from both SP and proxies trained models gave the highest sensitivity of 1.00 (as obtained from all the four models). CONCLUSION: It can be concluded that the combination of responses in a word recall task as obtained from the SP and proxies in the dementia study (based on the NHATS dataset) is clinically useful in predicting dementia cases. Also, the use of "word-delay" and "tell-words-you-can-recall" cannot reliably predict dementia as they resulted in poor performances in all the developed models, as shown in all the experiments. However, immediate-word recall is reliable in predicting dementia, as seen in all the experiments. This, therefore, shows the significance of immediate-word-recall cognitive assessment in predicting dementia and the efficiency of combining responses from both SP and proxies in the immediate-word-recall task.

Modeling a deep transfer learning framework for the classification of COVID-19 radiology dataset.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Coronavirus-2 or SARS-CoV-2), which came into existence in 2019, is a viral pandemic that caused coronavirus disease 2019 (COVID-19) illnesses and death. Research showed that relentless efforts had been made to improve key performance indicators for detection, isolation, and early treatment. This paper used Deep Transfer Learning Model (DTL) for the classification of a real-life COVID-19 dataset of chest X-ray images in both binary (COVID-19 or Normal) and three-class (COVID-19, Viral-Pneumonia or Normal) classification scenarios. Four experiments were performed where fine-tuned VGG-16 and VGG-19 Convolutional Neural Networks (CNNs) with DTL were trained on both binary and three-class datasets that contain X-ray images. The system was trained with an X-ray image dataset for the detection of COVID-19. The fine-tuned VGG-16 and VGG-19 DTL were modelled by employing a batch size of 10 in 40 epochs, Adam optimizer for weight updates, and categorical cross-entropy loss function. The results showed that the fine-tuned VGG-16 and VGG-19 models produced an accuracy of 99.23% and 98.00%, respectively, in the binary task. In contrast, in the multiclass (three-class) task, the fine-tuned VGG-16 and VGG-19 DTL models produced an accuracy of 93.85% and 92.92%, respectively. Moreover, the fine-tuned VGG-16 and VGG-19 models have MCC of 0.98 and 0.96 respectively in the binary classification, and 0.91 and 0.89 for multiclass classification. These results showed strong positive correlations between the models' predictions and the true labels. In the two classification tasks (binary and three-class), it was observed that the fine-tuned VGG-16 DTL model had stronger positive correlations in the MCC metric than the fine-tuned VGG-19 DTL model. The VGG-16 DTL model has a Kappa value of 0.98 as against 0.96 for the VGG-19 DTL model in the binary classification task, while in the three-class classification problem, the VGG-16 DTL model has a Kappa value of 0.91 as against 0.89 for the VGG-19 DTL model. This result is in agreement with the trend observed in the MCC metric. Hence, it was discovered that the VGG-16 based DTL model classified COVID-19 better than the VGG-19 based DTL model. Using the best performing fine-tuned VGG-16 DTL model, tests were carried out on 470 unlabeled image dataset, which was not used in the model training and validation processes. The test accuracy obtained for the model was 98%. The proposed models provided accurate diagnostics for both the binary and multiclass classifications, outperforming other existing models in the literature in terms of accuracy, as shown in this work.