1.
ACS Comb Sci
; 15(10): 541-5, 2013 Oct 14.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23978241
RESUMEN
Isothiazolothienopyridines have been prepared by a domino reaction (the SN2 reaction â the Thorpe-Ziegler reaction â the Thorpe-Guareschi reaction type) from disodium 4-cyanoisothiazole-3,5-dithiolate. By changing the order of addition of the alkylation reagents in the reaction with disodium 4-cyanoisothiazole-3,5-dithiolate both possible isomers of the isothiazolothienopyridines are synthesized. These isomers were further used in three-component domino reaction (the Knoevenagel reaction â the Michael reaction â the hetero-Thorpe-Ziegler reaction type) to obtain wide range of isomeric isothiazolothienopyranopyridines.