RESUMEN
Aphrocallistes vastus lectin (AVL) is a C-type marine lectin produced by sponges. Our previous study demonstrated that genes encoding AVL enhanced the cytotoxic effect of oncolytic vaccinia virus (oncoVV) in a variety of cancer cells. In this study, the inhibitory effect of oncoVV-AVL on Hela S3 cervical cancer cells, a cell line with spheroidizing ability, was explored. The results showed that oncoVV-AVL could inhibit Hela S3 cells growth both in vivo and in vitro. Further investigation revealed that AVL increased the virus replication, promote the expression of OASL protein and stimulated the activation of Raf in Hela S3 cells. This study may provide insight into a novel way for the utilization of lection AVL.
Asunto(s)
Adenina/análogos & derivados , Antineoplásicos/farmacología , Lectinas/farmacología , Virus Oncolíticos/patogenicidad , Poríferos , Tiramina/análogos & derivados , Virus Vaccinia/patogenicidad , Adenina/química , Adenina/farmacología , Adenina/uso terapéutico , Animales , Antineoplásicos/química , Antineoplásicos/uso terapéutico , Organismos Acuáticos , Proliferación Celular/efectos de los fármacos , Femenino , Células HeLa/efectos de los fármacos , Humanos , Lectinas/química , Lectinas/uso terapéutico , Tiramina/química , Tiramina/farmacología , Tiramina/uso terapéutico , Neoplasias del Cuello Uterino/tratamiento farmacológicoRESUMEN
BACKGROUND: Upper urinary tract urothelial carcinoma (UTUC) with multiple pathological types is extremely rare in the clinic, but the recurrence rate and mortality these patients are high. At present, there is no standard treatment for such cases. CASE PRESENTATION: We reported a case of ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation and rapid ileal metastasis and reviewed the literature related to different pathological types of upper urinary tract tumours to explore the diagnosis, treatment and prognosis characteristics of the disease, enhance our understanding of its clinical manifestations and history of evolution and provide guidance for avoiding missed diagnosis and misdiagnosis. CONCLUSION: There is no standard treatment for urinary malignant tumours with multiple pathological types; radical surgery is considered a suitable choice. Chemotherapy, targeted drug therapy and immunotherapy may be beneficial to the survival of patients. In short, these patients have a high risk of recurrence and metastasis and a poor prognosis.