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1.
Childs Nerv Syst ; 36(9): 1853-1857, 2020 09.
Artículo en Inglés | MEDLINE | ID: mdl-32661641

RESUMEN

PURPOSE: Self-limited epilepsy with centrotemporal spikes, formerly called benign epilepsy with centrotemporal spikes, or rolandic epilepsy, is an age-related and well-defined epileptic syndrome. Since seizures associated with rolandic spikes are infrequent and usually occur during sleep, and repetitive or prolonged EEG recording for diagnostic purposes is not necessary for diagnosis, reports of ictal video-electroencephalographic seizures in this syndrome are rare. We aimed to show ictal video-EEG of typical rolandic seizures. METHODS: We report the ictal video-EEG recordings of two children with rolandic epilepsy who presented typical rolandic seizures during routine recording. RESULTS: Case 1: A 9-year-old boy, with normal development, had his first seizure at 8 years old, characterized by paresthesia in his left face, blocking of speech, and drooling. Carbamazepine was started with seizure control. Case 2: A 10-year-old boy, with normal development, started with focal seizures during sleep, characterized by eye and perioral deviation, and speech arrest at age of 7. He started using oxcarbazepine. Both patients underwent routine electroencephalography for electroclinical diagnosis and presented a seizure. CONCLUSION: Although self-limited epilepsy with centrotemporal spikes is a very common epileptic syndrome, seizure visualization is very difficult, and these videos may bring didactical information for recognition of this usual presentation of benign childhood focal epilepsy.


Asunto(s)
Electroencefalografía , Epilepsia Rolándica , Carbamazepina/uso terapéutico , Niño , Documentación , Epilepsia Rolándica/complicaciones , Epilepsia Rolándica/diagnóstico , Epilepsia Rolándica/tratamiento farmacológico , Humanos , Masculino , Convulsiones/complicaciones , Convulsiones/diagnóstico
2.
Brain ; 138(Pt 6): 1629-41, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-25792528

RESUMEN

Epileptic discharges in focal epilepsy are frequently activated during non-rapid eye movement sleep. Sleep slow waves are present during this stage and have been shown to include a deactivated ('down', hyperpolarized) and an activated state ('up', depolarized). The 'up' state enhances physiological rhythms, and we hypothesize that sleep slow waves and particularly the 'up' state are the specific components of non-rapid eye movement sleep that mediate the activation of epileptic activity. We investigated eight patients with pharmaco-resistant focal epilepsies who underwent combined scalp-intracerebral electroencephalography for diagnostic evaluation. We analysed 259 frontal electroencephalographic channels, and manually marked 442 epileptic spikes and 8487 high frequency oscillations during high amplitude widespread slow waves, and during matched control segments with low amplitude widespread slow waves, non-widespread slow waves or no slow waves selected during the same sleep stages (total duration of slow wave and control segments: 49 min each). During the slow waves, spikes and high frequency oscillations were more frequent than during control segments (79% of spikes during slow waves and 65% of high frequency oscillations, both P ∼ 0). The spike and high frequency oscillation density also increased for higher amplitude slow waves. We compared the density of spikes and high frequency oscillations between the 'up' and 'down' states. Spike and high frequency oscillation density was highest during the transition from the 'up' to the 'down' state. Interestingly, high frequency oscillations in channels with normal activity expressed a different peak at the transition from the 'down' to the 'up' state. These results show that the apparent activation of epileptic discharges by non-rapid eye movement sleep is not a state-dependent phenomenon but is predominantly associated with specific events, the high amplitude widespread slow waves that are frequent, but not continuous, during this state of sleep. Both epileptic spikes and high frequency oscillations do not predominate, like physiological activity, during the 'up' state but during the transition from the 'up' to the 'down' state of the slow wave, a period of high synchronization. Epileptic discharges appear therefore more associated with synchronization than with excitability. Furthermore, high frequency oscillations in channels devoid of epileptic activity peak differently during the slow wave cycle from those in channels with epileptic activity. This property may allow differentiating physiological from pathological high frequency oscillations, a problem that is unresolved until now.


Asunto(s)
Ondas Encefálicas/fisiología , Epilepsia/fisiopatología , Lóbulo Frontal/fisiopatología , Fases del Sueño/fisiología , Electrodos Implantados , Electroencefalografía , Humanos
3.
Brain Topogr ; 29(3): 358-67, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-26920404

RESUMEN

To evaluate the possibility of detecting fast ripples (FRs) on the surface EEG of patients with focal pharmacoresistant epilepsy, and to investigate the relationship between scalp FRs and localization of the seizure onset zone (SOZ). We included 10 patients undergoing combined surface-intracranial EEG with ≥10 spikes in the surface EEG during the first 30 consecutive minutes of N3 sleep. FRs (≥4 consecutive oscillations above 250 Hz with an amplitude clearly exceeding that of the background) on the surface EEG (F3-C3, C3-P3, Fz-Cz, Cz-Pz, F4-C4, C4-P4) were visually marked, and verified by two EEG experts. FRs were categorized as related to the SOZ, if localized in the brain lobe of the SOZ. Low-amplitude FRs with a rate of 0.09/min were found in 6/10 patients: two exhibited events related to the SOZ, three showed no relationship with the SOZ, and in one patient the SOZ was not identified. It may be possible to detect FRs with surface EEG using subdermal electrodes in patients with focal epilepsy. The relationship between surface FRs and the SOZ remains unclear. Future studies aiming at a higher spatial EEG coverage are needed to elucidate their significance.


Asunto(s)
Encéfalo/fisiología , Electroencefalografía/instrumentación , Electroencefalografía/métodos , Adulto , Mapeo Encefálico , Electrodos Implantados , Epilepsias Parciales/fisiopatología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Convulsiones/fisiopatología , Procesamiento de Señales Asistido por Computador , Sueño/fisiología , Adulto Joven
4.
Epilepsia ; 56(4): 592-8, 2015 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-25754852

RESUMEN

OBJECTIVE: Although a clear correlation has been observed between high-frequency oscillations (HFOs) and the seizure-onset zone in distinct lesions, the role of the underlying pathologic substrates in the generation of HFOs is not well established. We aimed to investigate HFO correlates of different pathologic substrates in patients with drug-resistant epilepsy, and to examine the relation of HFOs with the anatomic location of the dysplastic lesion and surrounding tissue in patients with focal cortical dysplasia (FCD). METHODS: We studied consecutive patients with drug-resistant epilepsy who underwent intracranial electroencephalography (iEEG) investigations with depth electrodes at the Montreal Neurological Institute and Hospital, between November 2004 and May 2013. Inclusion criteria were the following: a focal lesion documented by magnetic resonance imaging (MRI); EEG recording at a 2,000 Hz sampling rate; and seizures starting from depth electrode contacts placed in lesion and perilesional tissue. RESULTS: Thirty-seven patients (13 FCD, 12 mesial temporal sclerosis, five cortical atrophy, three polymicrogyria, three nodular heterotopia, and one tuberous sclerosis) were included; 18 were women (median age 34). Ripples and fast ripples were found in all lesion types, except tuberous sclerosis, which showed no fast ripples. There was a significant difference in rates of ripples and fast ripples across different lesions (p < 0.001), with higher rates in FCD, mesial temporal sclerosis, and nodular heterotopia than in atrophy, polymicrogyria, and tuberous sclerosis. Regarding patients with FCD, HFOs rates differed significantly across the three types of tissue (lesional, perilesional, and nonlesional; p < 0.001), being higher within the borders of the MRI-visible dysplastic lesion, followed by the surrounding area, and rare in the remote cortex. SIGNIFICANCE: Our findings suggest that in patients who are all intractable, the HFO rates vary with different pathologies, and reflect different types of neuronal derangements. Our results also emphasize the potential usefulness of HFOs as an additional method to better define the extent of the epileptogenic dysplastic tissue in FCD.


Asunto(s)
Relojes Biológicos , Electrodos Implantados , Electroencefalografía/métodos , Epilepsias Parciales/diagnóstico , Epilepsias Parciales/fisiopatología , Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven
5.
Epileptic Disord ; 17(2): 188-93, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-25895540

RESUMEN

Epileptic spasms were defined by the International League Against Epilepsy Task Force on Classification and Terminology in 2001 as a specific seizure type. Epileptic spasms without hypsarrhythmia have been described in some series of patients, occurring either in infancy or childhood. More prolonged epileptic spasms without hypsarrhythmia were previously defined as a different seizure type, and referred to as "tonic spasm seizures". Here, we present a 5-year-old boy who started having epileptic spasms without hypsarrhythmia at 8 months of age, effectively treated with oxcarbazepine. With the withdrawal of medication, epileptic spasms returned. Video-EEG monitoring revealed high-voltage slow waves superimposed by low-voltage fast activity, followed by an electrodecremental phase and a burst of asymmetric fast activity, time-locked to clinical tonic spasm seizures. Brain MRI showed left temporal atrophy with temporal pole grey/white matter junction blurring and ictal PET-CT showed left basal frontal hypermetabolism. Seizures were refractory to several AEDs and vigabatrin was introduced with seizure cessation. Despite efforts to classify epileptic spasms, these are still considered as part of the group of unknown seizure types. In some cases, a focal origin has been suggested, leading to the term "periodic spasms" and "focal spasms". In this case, epileptic spasms without hypsarrhythmia, associated with tonic spasms, may be a variant of focal spasms and might be considered as an epileptic syndrome. [Published with video sequence].


Asunto(s)
Epilepsias Parciales/fisiopatología , Espasmos Infantiles/fisiopatología , Anticonvulsivantes/administración & dosificación , Anticonvulsivantes/farmacología , Carbamazepina/administración & dosificación , Carbamazepina/análogos & derivados , Carbamazepina/farmacología , Preescolar , Epilepsias Parciales/clasificación , Epilepsias Parciales/tratamiento farmacológico , Epilepsias Parciales/patología , Humanos , Lactante , Masculino , Oxcarbazepina , Espasmos Infantiles/clasificación , Espasmos Infantiles/tratamiento farmacológico , Espasmos Infantiles/patología , Vigabatrin/administración & dosificación
6.
Epilepsy Behav ; 26(1): 67-70, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-23220462

RESUMEN

Morphological variations of hippocampal formation (MVHF) are observed in patients with epilepsy but also in asymptomatic individuals. The precise role of these findings in epilepsy is not yet fully understood. This study analyzes the hippocampal formation (HF) morphology of asymptomatic individuals (n = 30) and of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) (n = 68), patients with malformations of cortical development (MCD) (n = 34), or patients with pure morphological variations of hippocampal formation (pure MVHF) (n = 12). Main clinical and electrophysiological data of patients with MVHF were also analyzed. Morphological variations of hippocampal formation are more frequently observed in patients with MCD than in patients with MTLE-HS or in asymptomatic individuals. Patients with pure morphological variations of hippocampal formation showed higher incidence of extratemporal seizure onset. Refractoriness seems to be more associated with other abnormalities, like HS or MCD, than with the HF variation itself. Thus, although morphological HF abnormalities might play a role in epileptogenicity, they seem to contribute less to refractoriness.


Asunto(s)
Ondas Encefálicas/fisiología , Epilepsia/patología , Epilepsia/fisiopatología , Hipocampo/patología , Neuroimagen , Adolescente , Adulto , Análisis de Varianza , Electroencefalografía , Femenino , Humanos , Masculino , Malformaciones del Desarrollo Cortical/patología , Malformaciones del Desarrollo Cortical/fisiopatología , Persona de Mediana Edad , Esclerosis/complicaciones , Esclerosis/patología , Adulto Joven
7.
Epileptic Disord ; 15(1): 80-3, 2013 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-23531515

RESUMEN

Gastaut type idiopathic childhood occipital epilepsy is an uncommon epileptic syndrome characterised by frequent seizures, most commonly presenting as elementary visual hallucinations or blindness. Other occipital (non-visual) symptoms may also occur. Interictal EEG typically shows occipital paroxysms, often with fixation-off sensitivity. Ictal EEG is usually characterised by interruption by paroxysms and sudden appearance of low-voltage, occipital, fast rhythm and/or spikes. Despite well described clinical and EEG patterns, to our knowledge, there are very few reports in the literature with video-EEG recording of either seizure semiology or fixation-off phenomena. We present a video-EEG recording of a 12-year-old girl with Gastaut type epilepsy, illustrating the interictal and ictal aspects of this syndrome. Our aim was to demonstrate the clinical and neurophysiological pattern of a typical seizure of Gastaut type epilepsy, as well as the fixation-off phenomena, in order to further clarify the typical presentation of this syndrome. [Published with video sequences].


Asunto(s)
Epilepsias Parciales/fisiopatología , Lóbulo Occipital/fisiopatología , Niño , Electroencefalografía , Femenino , Humanos
8.
Epilepsy Behav ; 24(1): 120-5, 2012 May.
Artículo en Inglés | MEDLINE | ID: mdl-22520586

RESUMEN

We examined the relationship between presence and frequency of different types of auras and side of lesion and post surgical outcomes in 205 patients with medically intractable mesial temporal lobe epilepsy (MTLE) with unilateral hippocampal sclerosis (HS). With respect to the number of auras, multiple auras were not associated with side of lesion (p=0.551). The side of HS was not associated with the type of auras reported. One hundred fifty-seven patients were operated. The occurrence of multiple auras was not associated with post-surgical outcome (p=0.740). The presence of extratemporal auras was significantly higher in patients with poor outcome. In conclusion, this study suggests that the presence of extratemporal auras in patients with MTLE-HS possibly reflects extratemporal epileptogenicity in these patients, who otherwise showed features suggestive of TLE. Therefore, TLE-HS patients undergoing pre-surgical evaluation and presenting clinical symptoms suggestive of extratemporal involvement should be more extensively evaluated to avoid incomplete resection of the epileptogenic zone.


Asunto(s)
Lobectomía Temporal Anterior/métodos , Epilepsia del Lóbulo Temporal/cirugía , Epilepsia/cirugía , Lateralidad Funcional/fisiología , Hipocampo/patología , Adolescente , Adulto , Epilepsia/clasificación , Epilepsia/etiología , Epilepsia del Lóbulo Temporal/complicaciones , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Esclerosis/complicaciones , Esclerosis/patología , Resultado del Tratamiento , Adulto Joven
9.
J Clin Neurophysiol ; 39(4): 259-264, 2022 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-34999637

RESUMEN

SUMMARY: Zika virus (ZIKV) has been shown to be highly neurotropic; neurologic disorders are a common complication of this infection. Encephalitis-an inflammation of the brain parenchyma associated with neurologic dysfunction-is a rare complication of ZIKV infections. It affects patients from young to elderly ages. Clinical presentation of ZIKV encephalitis may be heterogeneous, including altered mental status (decreased or altered level of consciousness, lethargy, or personality change), seizures, and focal deficits. Complementary diagnostic investigation should include neuroimaging, lumbar puncture, and EEG. Neuroimaging findings in ZIKV encephalitis are not specific and may be diverse, including normal findings, hyperintense lesions on MRI involving cortical or subcortical structures, symmetric or asymmetric lesions involving supra or infratentorial regions, and more widespread involvement such as brain swelling. A remarkable scarcity of neurophysiological data on ZIKV encephalitis was found in the literature. In line with other diagnostic examinations, there are no neurophysiological findings suggestive or specific of the disease. EEG in ZIKV encephalitis showed different results: normal or diffuse disorganization of background activity, asymmetry with abnormal focal slow waves, focal epileptic discharges or generalized spike-wave and multispike-wave complexes, and periods of generalized voltage attenuation.


Asunto(s)
Encefalitis , Infección por el Virus Zika , Virus Zika , Anciano , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Encefalitis/diagnóstico , Humanos , Neuroimagen/métodos , Infección por el Virus Zika/complicaciones , Infección por el Virus Zika/diagnóstico , Infección por el Virus Zika/patología
10.
J Clin Neurophysiol ; 37(3): 246-252, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-31365358

RESUMEN

PURPOSE: In comatose patients, distinguishing between nonconvulsive status epilepticus and diffuse structural or metabolic encephalopathies is often challenging. Both conditions can generate periodic discharges on EEG with similar morphology and periodicity. We investigated the occurrence of high-frequency oscillations-potential biomarkers of epileptogenesis-on scalp EEG of comatose patients with periodic discharges in the EEG. METHODS: Fifteen patients were included. Patients were divided into three groups, according to underlying etiology: Group 1, seizure related; group 2, structural; group 3, nonstructural. EEG recordings were compared with respect to the presence and rates of gamma (30-80 Hz) and ripples (80-250 Hz). RESULTS: Patients were 23 to 106 years old (median, 68 years); 60% were female. 206 channels were eligible for analysis (median, 15 channels/patient). Overall, 43% of channels showed gamma, and 24% had ripples. Group 2 showed the highest proportion of channels with gamma (47%), followed by group 1 (38%) and group 3 (36%). Mean gamma rates were higher in group 2 (4.65 gamma/min/channel) than in group 1 (1.52) and group 3 (1.44) (P < 0.001). Group 2 showed the highest proportion of channels with ripples (29.2%), followed by group 1 (15%) and group 3 (24.2%). Mean ripple rates were higher in group 2 (5.09 ripple/min/channel) than in group 1 (0.96) and group 3 (0.83) (P < 0.001). CONCLUSIONS: Fast oscillations, including high-frequency oscillations, can be detected in scalp EEG of patients with altered consciousness. High rates of fast activity may suggest an underlying structural brain lesion. Future studies are needed to determine whether fast oscillations in the setting of acute/subacute brain lesions are a biomarker of subsequent development of human epilepsy.


Asunto(s)
Encefalopatías/complicaciones , Encefalopatías/diagnóstico , Coma/etiología , Electroencefalografía/métodos , Estado Epiléptico/complicaciones , Estado Epiléptico/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Coma/fisiopatología , Cuidados Críticos/métodos , Diagnóstico Diferencial , Femenino , Humanos , Unidades de Cuidados Intensivos , Masculino , Persona de Mediana Edad , Periodicidad , Cuero Cabelludo , Adulto Joven
11.
PLoS One ; 12(9): e0184050, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28886073

RESUMEN

INTRODUCTION: Nonconvulsive seizures (NCS) are frequent in hospitalized patients and may further aggravate injury in the already damaged brain, potentially worsening outcomes in encephalopathic patients. Therefore, both early seizure recognition and treatment have been advocated to prevent further neurological damage. OBJECTIVE: Evaluate the main EEG patterns seen in patients with impaired consciousness and address the effect of treatment with antiepileptic drugs (AEDs), continuous intravenous anesthetic drugs (IVADs), or the combination of both, on outcomes. METHODS: This was a single center retrospective cohort study conducted in a private, tertiary care hospital. Consecutive adult patients with altered consciousness submitted to a routine EEG between January 2008 and February 2011 were included in this study. Based on EEG pattern, patients were assigned to one of three groups: Group Interictal Patterns (IP; EEG showing only interictal epileptiform discharges or triphasic waves), Group Rhythmic and Periodic Patterns (RPP; at least one EEG with rhythmic or periodic patterns), and Group Ictal (Ictal; at least one EEG showing ictal pattern). Groups were compared in terms of administered antiepileptic treatment and frequency of unfavorable outcomes (modified Rankin scale ≥3 and in-hospital mortality). RESULTS: Two hundred and six patients (475 EEGs) were included in this analysis. Interictal pattern was observed in 35.4% (73/206) of patients, RPP in 53.4% (110/206) and ictal in 11.2% (23/206) of patients. Treatment with AEDs, IVADs or a combination of both was administered in half of the patients. While all Ictal group patients received treatment (AEDs or IVADs), only 24/73 (32.9%) IP group patients and 55/108 (50.9%) RPP group patients were treated (p<0.001). Hospital length of stay (LOS) and frequency of unfavorable outcomes did not differ among the groups. In-hospital mortality was higher in IVADs treated RPP patients compared to AEDs treated RPP patients [11/19 (57.9%) vs. 11/36 (30.6%) patients, respectively, p = 0.049]. Hospital LOS, in-hospital mortality and frequency of unfavorable outcomes did not differ between Ictal patients treated exclusively with AEDs or IVADs. CONCLUSION: In patients with acute altered consciousness and abnormal routine EEG, antiepileptic treatment did not improve outcomes regardless of the presence of periodic, rhythmic or ictal EEG patterns.


Asunto(s)
Trastornos de la Conciencia/diagnóstico , Trastornos de la Conciencia/psicología , Estado de Conciencia , Electroencefalografía , Anciano , Anciano de 80 o más Años , Anticonvulsivantes/uso terapéutico , Lesiones Traumáticas del Encéfalo/complicaciones , Comorbilidad , Estado de Conciencia/efectos de los fármacos , Trastornos de la Conciencia/tratamiento farmacológico , Trastornos de la Conciencia/etiología , Diagnóstico por Imagen , Femenino , Humanos , Masculino , Estudios Retrospectivos , Resultado del Tratamiento , Flujo de Trabajo
12.
Epilepsy Res ; 127: 200-206, 2016 11.
Artículo en Inglés | MEDLINE | ID: mdl-27635628

RESUMEN

OBJECTIVE: High-frequency oscillations (80-500Hz; HFOs) have been shown to be a specific biomarker of the seizure-onset zone. The relationship of HFOs with seizures having different intracranial electroencephalography (iEEG) morphological onsets, however, has shown significant relationships in experimental animals but has not been studied in humans. We investigated how interictal and ictal HFOs relate to different seizure-onset morphological patterns. METHODS: We analyzed the most representative seizure type of 37 patients with drug-resistant focal epilepsy who underwent iEEG for diagnostic evaluation. According to the morphology, 211 seizure-onset zone channels were classified in six patterns (low-voltage fast activity; sharp activity at ≤13Hz; low-frequency high-amplitude periodic spikes; burst of high-amplitude polyspikes; spike-and-wave activity; and delta brush). Interictal and ictal HFOs were compared between the six seizure-onset patterns. RESULTS: Interictal ripple and fast ripple rates differed significantly across seizure-onset patterns (p<0.001). Significant differences were also found for ictal HFOs density across the different seizure-onset patterns (p<0.001). Sharp activity at ≤13Hz was associated with the lowest interictal HFO rate suggesting either that the mechanism that generates this type of EEG morphology do not generate HFOs or possibly that this pattern is more likely to be generated in a region of seizure spread. Regarding the difference in HFO density between pre-ictal baseline and seizure-onset section across the six patterns, burst of high-amplitude polyspikes and delta brushes had the highest densities of both ripples and fast ripples (p<0.001). SIGNIFICANCE: We demonstrated that distinct seizure-onset patterns correlate specific interictal and ictal HFO profiles confirming that seizures with different morphological patterns likely have different mechanisms of generation. This study emphazises that, in clinical practice, seizure-onset patterns should be distinguished and specified when analyzing HFOs, particularly if they are used in presurgical evaluation to better localize the seizure-onset zone.


Asunto(s)
Encéfalo/fisiopatología , Epilepsia Refractaria/fisiopatología , Electrocorticografía , Epilepsias Parciales/fisiopatología , Convulsiones/fisiopatología , Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven
13.
Clin Neurophysiol ; 127(3): 1794-802, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26762951

RESUMEN

OBJECTIVE: To evaluate scalp ripples distribution in secondary bilateral synchrony as a tool to lateralize the epileptic focus and to differentiate focal from generalized epilepsy. METHODS: Seventeen EEG recordings with bilateral synchronous discharges of focal (focal group-FG: 10) and generalized (generalized group-GG: 7) epilepsy patients were selected for spikes and ripples marking; the spike-normalized ripple rate was calculated in each hemisphere (right/left - anterior/posterior) and a ripple-dominant hemisphere (the one with the highest rate) was identified. Concordance in FG between the ripple dominant hemisphere and the hemisphere of clinical lateralization was evaluated. The ripple-dominant/ripple-nondominant spike-normalized ripple rate ratio was studied to compare groups. RESULTS: In FG the hemisphere of clinical lateralization and the ripple-dominant hemisphere were 100% concordant. In GG only 3/7 patients showed ripples (vs 10/10 FG), all with anterior dominance. No difference in hemisphere ripple dominance between groups was found. CONCLUSIONS: Ripples in secondary bilateral synchrony help to lateralize the epileptic focus but do not help to differentiate between focal and generalized epilepsy. This is the first report of visually identified ripples in idiopathic generalized epilepsy. SIGNIFICANCE: Ripples confirm the clinical lateralization of the epileptic focus in secondary bilateral synchrony but cannot distinguish between focal and generalized epilepsy.


Asunto(s)
Potenciales de Acción/fisiología , Electroencefalografía/métodos , Epilepsias Parciales/diagnóstico , Epilepsias Parciales/fisiopatología , Epilepsia Generalizada/diagnóstico , Epilepsia Generalizada/fisiopatología , Adulto , Electroencefalografía/normas , Femenino , Humanos , Masculino , Persona de Mediana Edad , Telemetría/métodos , Telemetría/normas , Adulto Joven
14.
Seizure ; 21(9): 685-90, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22874854

RESUMEN

PURPOSE: We analyzed the association of granule cell dispersion (GCD) with memory performance, clinical data and surgical outcome in a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS). METHOD: Hippocampal specimens from 54 patients with MTLE (27 patients with right MTLE and 27 with left MTLE) and unilateral MTS, who were separated into GCD and no-GCD groups and thirteen controls were studied. Quantitative neuropathological evaluation was performed using hippocampal sections stained with NeuN. Patients' neuropsychological measures, clinical data, type of MTS and surgical outcome were reviewed. RESULTS: GCD occurred in 28 (51.9%) patients. No correlation between GCD and MTS pattern, clinical data or surgical outcome was found. The presence of GCD was correlated with worse visuospatial memory performance in right MTLE, but not with memory performance in left MTLE. CONCLUSION: GCD may be related to memory impairment in right MTLE-MTS patients. However, the role of GCD in memory function is not precisely defined.


Asunto(s)
Epilepsia del Lóbulo Temporal/epidemiología , Epilepsia del Lóbulo Temporal/patología , Hipocampo/patología , Trastornos de la Memoria/epidemiología , Trastornos de la Memoria/patología , Adulto , Anciano , Femenino , Hipocampo/citología , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos
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