[Lymphocytic duodenosis: etiological study and clinical presentations]. / Duodenosis linfocítica: estudio etiológico y formas de presentación clínica.

INTRODUCTION: Lymphocytic duodenosis (LD) is a characteristic lesion in the initial phases of celiac disease (CD) but can be associated with many other entities. The aim of this study was to evaluate the prevalence of distinct causes of LD and possible differences in clinical presentation according to etiology. METHODS: A retrospective study was performed that included 194 patients diagnosed with LD (more than 25 intraepithelial lymphocytes per 100 epithelial cells). A preestablished strategy to evaluate the cause of the disease was followed that included celiac serology (antitransglutaminase antibodies), HLA-DQ2/DQ8 genotypes, diagnosis of Helicobacter pylori and small intestinal bacterial overgrowth (SIBO). Diagnosis of CD was established on the basis of clinical and histological response to a gluten-free diet in patients with positive serology or compatible findings on HLA-DQ2 (at least one of the alleles) or -DQ8 (both alleles) study. RESULTS: The most frequent cause of LD was CD (39%), followed by SBBO (22%), H.pylori (14%), CD and SIBO (12%), and other causes (13%). Most of the patients (83%) had a compatible HLA-DQ2 or -DQ8 genotype. In these patients, the most frequent diagnosis was CD (46%), while in the absence of HLA-DQ2/DQ8, the most frequent diagnoses were SIBO (44%) and H. pylori (22%). CD was the most frequent diagnosis in patients referred for dyspepsia, diarrhea and anemia, while H. pylori was the most frequent diagnosis in patients with abdominal pain. CONCLUSIONS: The most common causes of LD in our environment are CD, followed by SIBO and H. pylori infection.

Spectrum of gluten-sensitive enteropathy in patients with dysmotility-like dyspepsia.

BACKGROUND: Dysmotility-like dyspepsia symptoms are frequent in patients with gluten-sensitive enteropathy (GSE). Current data suggest that patients with mild enteropathy may be present with gluten-sensitive symptoms and complications. AIM: To investigate the prevalence of GSE, including mild enteropathy, in patients with dysmotility-like dyspepsia symptoms. METHODS: We retrospectively studied 142 patients who presented dysmotility-like dyspepsia symptoms and normal upper gastrointestinal endoscopy. Endoscopic duodenal biopsies were taken and processed using hematoxylin-eosin staining and CD3 immunophenotyping. In patients with enteropathy (number of intraepithelial lymphocytes greater than 25 per 100 enterocytes) we also performed coeliac serology (anti-tissue transglutaminase IgA) and HLA-DQ2/DQ8 genotyping. A gluten-free diet was offered if one of these markers was positive. The final GSE diagnosis was established based on clinical and histopathological response to the gluten-free diet after 18 months of follow-up. RESULTS: Fifty-one patients (35.9%) had enteropathy; 4 (2.8%) Marsh type 3b, 24 (16.9%) Marsh type 3a, 3 (2.1%) Marsh type 2, and 20 (14.1%) Marsh type 1. A positive serology result was extremely low (6.7%) in mild enteropathy (Marsh type 1-3a) in contrast with Marsh type 3b patients (50%). Most patients with enteropathy had positive HLA DQ2 or -DQ8 genotyping (84.1%). Out of the 37 patients who started a gluten-free diet, 34 (91.9%) improved their symptoms, and 28 of 32 (87.5%) had a histopathological or serological response. A final GSE diagnosis was established in 28 of the 142 patients (19.7%). CONCLUSION: Gluten-sensitive enteropathy can be a frequent and unsuspected cause of dysmotility-like dyspepsia.

Lipotransferencia: una alternativa para el tratamiento de la deformidad facial adquirida / Lipotransfer: an alternative for the treatment of acquired facial deformity / A lipotransferência: uma alternativa para o tratamento da deformidade facial adquirida

RESUMEN Se presentó el caso de un paciente masculino de 58 años, con antecedentes de salud aparente, que refiere haber recibido tratamiento quirúrgico por fractura compleja de tercio medio facial (fracturas tipo Lefort II y malar III derecha), el mismo refiere inconformidad estética por la deformidad facial postraumática que presenta. Se decidió su ingreso en el Servicio de Cirugía Maxilofacial del Hospital Universitario "General Calixto García" para su tratamiento. Se diagnosticó deformidad postraumática secundaria a una fractura facial compleja y su consiguiente daño estético. Los resultados alcanzados con la utilización de la lipotransferencia de tejido graso abdominal para el tratamiento de la deformidad facial fueron satisfactorios con permanencia y estabilidad en un año, a la vez que cumplió con las expectativas del paciente. La lipotransferencia resulta una alternativa viable en el tratamiento de las deformidades faciales adquiridas.

ABSTRACT The case of a 58-year-old male patient was presented, with a history of apparent health, who reported having received surgical treatment for a complex fracture of the middle facial third (fractures Lefort II and right malar III), the same refers to aesthetic disagreement for the deformity posttraumatic facial presenting. It was decided to enter the Maxillofacial Surgery Service of the University Hospital "General Calixto García" for treatment. Posttraumatic deformity was diagnosed secondary to a complex facial fracture and its consequent aesthetic damage. The results achieved with the use of abdominal fatty tissue lipotransfer for the treatment of facial deformity were satisfactory with permanence and stability in one year, while meeting the patient's expectations. Lipotransfer is a viable alternative in the treatment of acquired facial deformities.

RESUMO Foi apresentado o caso de um paciente do sexo masculino, 58 anos, com histórico aparente de saúde, que relatou ter recebido tratamento cirúrgico para uma fratura complexa do terço facial médio (fraturas de Lefort II e malar III direita), o mesmo se refere a discordância estética quanto à deformidade apresentação facial pós-traumática. Foi decidido entrar no Serviço de Cirurgia Maxilofacial do Hospital Universitário "General Calixto García" para tratamento. A deformidade pós-traumática foi diagnosticada secundária a uma fratura facial complexa e seu conseqüente dano estético. Os resultados obtidos com o uso da lipotransferência de tecido adiposo abdominal para o tratamento da deformidade facial foram satisfatórios com permanência e estabilidade em um ano, atendendo às expectativas do paciente. A lipotransferência é uma alternativa viável no tratamento de deformidades faciais adquiridas.

[Referrals and sex of physicians and patients: a gender analysis, Andalussia, Spain]. / Derivaciones en los centros de salud de Andalucía según el sexo de profesionales y pacientes: un análisis de género.

BACKGROUND: It has been identified differences of medical care practice in primary care related to physician's sex. Simultaneously, there are gender inequalities in the assignment of health resources. Both aspects give rise to an increasing growing interest in the management and provision of health services. OBJECTIVES: To examine the differences in the referral practice made by female and male primary care physicians working in health centers in Andalusia, to consider whether there are disparities in referrals received by men and women, and to examine the interaction between patient's sex and physician's sex. METHODS: Observational, cross-sectional, and multicenter study. POPULATION: 4 health districts in Andalucía and their physicians. SAMPLE: 382 physicians. MEASUREMENTS: referral rate per visit (RV), referral rate per patient quota (RQ), patient's sex, physician: sex, age, postgraduate family medicine specialty, size of the patient quota by sex, mean number of patients/day by sex, mean age of the patient quota by sex, and proportion of men in the quota. Health center: urban / rural, size of the team, enrolled population, and postgraduate family medicine specialty's accreditation. SOURCES: databases of health districts. PERIOD OF STUDY: 2010. ANALYSIS: Bivariate and multivariate multilevel analysis of the referral rate per visit with mixed Poisson model. RESULTS: In 2010 382 physicians made 129,161 referrals to specialized care. The RQ was 23.47 and the RV was 4.92. The RQ in women and men was 27.23 and 19.78 for women physicians, being 27.37 and 19.51 for male physicians. The RV in women and men was 4.92 and 5.48 for women physicians, being 4.54 and 4.93 for male physicians. CONCLUSION: There are no differences in referral according to physician's sex. However, there are signs that might indicate the existence of gender inequality, and women patient received less referrals. There are no physician-patient's sex interaction.

Derivaciones en los centros de salud de Andalucía según el sexo de profesionales y pacientes. Un análisis de género / Referrals and sex of physicians and patients. A gender analysis, Andalussia, Spain

Fundamento: En atención primaria se han identificado diferencias de práctica según sexo del profesional y, simultáneamente, existen des- igualdades de género en la asignación de recursos sanitarios, aspectos ambos que suscitan un interés creciente en la gestión y provisión de servicios de salud. El objetivo del estudio es conocer si existen diferencias de práctica en las derivaciones sanitarias realizadas por médicas y médicos de familia (MF) de centros de salud de Andalucía, si existen desigualdades en las derivaciones recibidas por hombres y mujeres, y si existe inter- acción sexo de profesional sexo de paciente. Métodos: Estudio transversal y multicéntrico. Población: MF de 4 distritos sanitarios (DDSS). Muestra: 382 MF. Variables: tasa de derivaciones por visita (TDxV), tasa de derivaciones por cupo (TDxC), sexo de paciente; sexo, edad, y formación postgraduada en medicina familiar de MF, tamaño del cupo por sexo, media de visitas /paciente por sexo, edad media del cupo por sexo, y proporción de hombres en el cupo; centro de salud urbano/rural, tamaño del equipo, población adscrita y acreditación docente. Fuentes: bases de datos de los DDSS. Análisis estadístico: descriptivo. Bivariante y multivariante mediante análisis multinivel de la TDxV con modelo mixto de Poisson. Resultados: En 2010 los/as 382 MF realizaron 129.161 derivaciones a especialistas. La TDxC fue 23,47 y la TDxV es 4,92. Las TDxC de las médicas fue 27,23 en mujeres y 19,78 en hombres y las de los médicos 27,37 en mujeres y 19,51 en hombres. La TDxV de las médicas fueron 4,92 en mujeres y 5,48 en hombres y para los médicos 4,54 y 4,93 respectivamente. Conclusiones: No existen diferencias en las derivaciones según sexo de las mujeres son menos derivadas. No existe interacción sexo profesional-sexo paciente (AU)

Background: It has been identified differences of medical care practice in primary care related to physician’s sex. Simultaneously, there are gender inequalities in the assignment of health resources. Both aspects give rise to an increasing growing interest in the management and provi- sion of health services. Objectives: To examine the differences in the referral practice made by female and male primary care physicians working in health centers in Andalusia, to consider whether there are disparities in referrals received by men and women, and to examine the interaction bet- ween patient’s sex and physician’s sex. Methods: Observational, cross-sectional, and multicenter study. Population: 4 health districts in Andalucía and their physicians. Sample: 382 physicians. Measurements: referral rate per visit (RV), referral rate per patient quota (RQ), patient's sex, physician: sex, age, postgraduate family medicine specialty, size of the patient quota by sex, mean number of patients/day by sex, mean age of the patient quota by sex, and proportion of men in the quota. Health center: urban / rural, size of the team, enrolled population, and postgraduate family medicine specialty's accreditation. Sources: databases of health districts. Period of study: 2010. Analysis: Bivariate and multivariate multilevel analysis of the referral rate per visit with mixed Poisson model. Results: In 2010 382 physicians made 129,161 referrals to specialized care. The RQ was 23.47 and the RV was 4.92. The RQ in women and men was 27.23 and 19.78 for women physicians, being 27.37 and 19.51 for male physicians. The RV in women and men was 4.92 and 5.48 for women physicians, being 4.54 and 4.93 for male physicians. Conclusion: There are no differences in referral according to physician´s sex. However, there are signs that might indicate the existence of men patient received less referrals. There are no physician-patient's sex interaction (AU)

Spectrum of gluten-sensitive enteropathy in patients with dysmotility-like dyspepsia / Espectro de la enteropatía sensible al gluten en pacientes con dispepsia de tipo dismotilidad

Background Dysmotility-like dyspepsia symptoms are frequent in patients with gluten-sensitive enteropathy (GSE). Current data suggest that patients with mild enteropathy may be present with gluten-sensitive symptoms and complications. Aim To investigate the prevalence of GSE, including mild enteropathy, in patients with dysmotility-like dyspepsia symptoms. Methods We retrospectively studied 142 patients who presented dysmotility-like dyspepsia symptoms and normal upper gastrointestinal endoscopy. Endoscopic duodenal biopsies were taken and processed using hematoxylin–eosin staining and CD3 immunophenotyping. In patients with enteropathy (number of intraepithelial lymphocytes greater than 25 per 100 enterocytes) we also performed coeliac serology (anti-tissue transglutaminase IgA) and HLA-DQ2/DQ8 genotyping. A gluten-free diet was offered if one of these markers was positive. The final GSE diagnosis was established based on clinical and histopathological response to the gluten-free diet after 18 months of follow-up. Results Fifty-one patients (35.9%) had enteropathy; 4 (2.8%) Marsh type 3b, 24 (16.9%) Marsh type 3a, 3 (2.1%) Marsh type 2, and 20 (14.1%) Marsh type 1. A positive serology result was extremely low (6.7%) in mild enteropathy (Marsh type 1–3a) in contrast with Marsh type 3b patients (50%). Most patients with enteropathy had positive HLA DQ2 or -DQ8 genotyping (84.1%). Out of the 37 patients who started a gluten-free diet, 34 (91.9%) improved their symptoms, and 28 of 32 (87.5%) had a histopathological or serological response. A final GSE diagnosis was established in 28 of the 142 patients (19.7%).Conclusion Gluten-sensitive enteropathy can be a frequent and unsuspected cause of dysmotility-like dyspepsia (AU)

Antecedentes La dispepsia de tipo dismotilidad es frecuente en pacientes con enteropatía sensible al gluten (ESG). Los datos actuales sugieren que los pacientes con enteropatía leve pueden presentar síntomas y complicaciones gluten dependientes. Objetivo Investigar la prevalencia de ESG, incluida la enteropatía leve, en pacientes con dispepsia tipo dismotilidad. Métodos Estudio retrospectivo de 142 pacientes que presentaban dispepsia de tipo dismotilidad y normalidad en la endoscopia digestiva alta. Se realizaron biopsias duodenales y se procesaron mediante tinción de hematoxilina-eosina e inmunofenotipo CD3. En los pacientes con enteropatía (número de linfocitos intraepiteliales superior a 25 por cada 100 enterocitos) también se realizó una serología celíaca (anti-transglutaminasa tisular IgA) y genotipado HLA-DQ2/DQ8. Si uno de estos marcadores resultaba positivo, se ofrecía al paciente iniciar una dieta sin gluten. El diagnóstico final de ESG se estableció en función de la respuesta clínica e histopatológica a la dieta sin gluten después de 18 meses de seguimiento. Resultados Cincuenta y un pacientes (35,9%) presentaban enteropatía, 4 (2,8%) de Marsh tipo 3b, 24 (16,9%) Marsh tipo 3a, 3 (2,1%) Marsh tipo 2, y 20 (14,1%) Marsh tipo 1. La positividad serológica fue extremadamente baja (6,7%) en la enteropatía leve (Marsh tipo 1-3a), al contrario que en los pacientes con una lesión Marsh tipo 3b (50%). La mayoría de los pacientes con enteropatía presentaban valores positivos para el genotipado HLA DQ2 o -DQ8 (84,1%). De los 37 pacientes que iniciaron una dieta sin gluten, en 34 (91,9%) mejoraron los síntomas, y 28 de 32 (87,5%) presentaron respuesta histopatológica o serológica. Un diagnóstico final de ESG se estableció en 28 de los 142 pacientes (19,7%).Conclusión La enteropatía sensible al gluten puede ser una causa frecuente e insospechada de dispepsia de tipo dismotilidad (AU)

Duodenosis linfocítica: estudio etiológico y formas de presentación clínica / Lymphocytic duodenosis: etiological study and clinical presentations

INTRODUCCIÓN: La duodenosis linfocítica (DL) es una lesión característica en las fases iniciales de la enfermedad celíaca (EC), pero puede asociarse a otras muchas entidades. El objetivo de este trabajo fue evaluar la prevalencia de las diferentes causas de DL y valorar posibles diferencias en la presentación clínica según la etiología responsable. Métodos Estudio retrospectivo que incluye 194 pacientes diagnosticados de una DL (más de 25 linfocitos intraepiteliales por 100 células epiteliales). Se siguió una estrategia de evaluación etiológica definida que incluyó serología celíaca (anticuerpos antitransglutaminasa), genotipos HLA-DQ2/DQ8, diagnóstico Helicobacter pylori (H. pylori) y sobrecrecimiento bacteriano intestinal (SBID). El diagnóstico de EC se estableció en función de la respuesta clínica e histológica a una DSG en pacientes con serología positiva o un estudio HLA-DQ2 (al menos uno de los alelos) o −DQ8 (ambos alelos) compatibles. Resultados La EC (39%) resultó la causa más frecuente de DL, seguida por SBID (22%), H. pylori (14%), EC y SBID (12%) y otras causas (13%). La mayoría (83%) de los pacientes presentaron un genotipo HLA-DQ2 o −DQ8 compatible. En estos pacientes el diagnóstico más frecuente fue la EC (46%), mientras que en ausencia de HLA-DQ2/DQ8 los diagnósticos más frecuentes fueron el SBID (44%) y H. pylori (22%). En los pacientes enviados por dispepsia, diarrea y anemia, la EC fue el diagnóstico más frecuente, mientras que H. pylori lo fue en los pacientes con dolor abdominal. Conclusiones La EC, seguida del SBID y la infección por H. pylori, constituyen las causas más frecuentes de DL en nuestro medio

INTRODUCTION: Lymphocytic duodenosis (LD) is a characteristic lesion in the initial phases of celiac disease (CD) but can be associated with many other entities. The aim of this study was to evaluate the prevalence of distinct causes of LD and possible differences in clinical presentation according to etiology. METHODS: A retrospective study was performed that included 194 patients diagnosed with LD(more than 25 intraepithelial lymphocytes per 100 epithelial cells). A preestablished strategy to evaluate the cause of the disease was followed that included celiac serology (antitransglutaminase antibodies), HLA-DQ2/DQ8 genotypes, diagnosis of Helicobacter pylori and small intestinal bacterial overgrowth (SIBO). Diagnosis of CD was established on the basis of clinical and histological response to a gluten-free diet in patients with positive serology or compatible findings on HLA-DQ2 (at least one of the alleles) or -DQ8 (both alleles) study. RESULTS: The most frequent cause of LD was CD (39%), followed by SBBO (22%), H.pylori (14%), CD and SIBO (12%), and other causes (13%). Most of the patients (83%) had a compatible HLA-DQ2 or -DQ8 genotype. In these patients, the most frequent diagnosis was CD (46%), while in the absence of HLA-DQ2/DQ8, the most frequent diagnoses were SIBO (44%) and H. pylori (22%). CD was the most frequent diagnosis in patients referred for dyspepsia, diarrhea and anemia, while H. pylori was the most frequent diagnosis in patients with abdominal pain. CONCLUSIONS: The most common causes of LD in our environment are CD, followed by SIBO and H. pylori infection

Utilización de laserpuntura en úlceras de miembros inferiores / Laserpuntura use in ulcers of inferior members

Se exponen los resultados obtenidos con el empleo de la laserpuntura a un total de 21 casos remitidos por el Servicio de Angiología con el diagnóstico de úlceras de tipo flebotónicas y postraumáticas al Hospital General "Ciro Redondo"de Artemisa. La información sobre los pacientes se registró en un documento confeccionado al efecto. En la investigación se usó un modelo de grupo único, lineal, y se les aplicó a las tablas el cálculo de X2, así como el valor promedio. Los resultados que se obtuvieron fueron de 95,2 por ciento de mejoría y cura de las lesiones y el 90 por ciento de confianza en afirmar que las úlceras de causa traumática evolucionan de manera favorable y más rápida que las de causa venosa, y reafirman la ventaja de esta modalidad de tratamiento(AU)

The results obtained using laser-puncture in a total of 21 cases referred to the Angiology Service of "Ciro Redondo" General Hospital, in Artemisa province, are shown. Information on patients was registered in a document designed for that purpose. In research, we used a form of linear unique group and the X2 estimate and the average value were applied to the tables. It was obtained 95.2 percent of improvement and cure of lesions and 90 percent of confidence on guaranteeing that the ulcers of traumatic origin evolve in a favorable way and more quickly than those of venous origin, which reaffirms the advantages of this treatment modality(AU)

Interacciones farmacológicas en población polimedicada / No disponible

No disponible

Diez años de programa de detección precoz de cáncer de mama en el distrito Almería / Ten years of early breast cancer detection programme in the Almería district

No disponible

No disponible