1.
J Org Chem
; 81(11): 4566-75, 2016 06 03.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27177249
RESUMEN
A synthesis route to the pentacyclic alkaloid (-)-gilbertine, which features a cyclization cascade passing through a transient indolidene intermediate, was pursued. A key stereochemical relationship was set via a Nicholas-type enolate alkylation. Ultimately, undesired C-N cyclization thwarted the final projected C-C bond forming ring closure, and gilbertine could not be prepared by this route.