Gamified E-learning in medical terminology: the TERMInator tool.

BACKGROUND: Proficiency in medical terminology is an essential competence of physicians which ensures reliable and unambiguous communication in everyday clinical practice. The attendance of a course on medical terminology is mandatory for human and dental medicine students in Germany. Students' prerequisites when entering the course are diverse and the key learning objectives are achieved to a varying degree. METHODS: A new learning space, the "TERMInator", was developed at the University Medicine Greifswald to meet the medical students' individual learning needs better. The interactive e-learning course serves as a supplement to the seminars, lectures and tutorials to rehearse and practically apply the course contents at an individual pace. It uses gamification elements and is supplied via the learning platform Moodle. The TERMInator was pilot implemented in two consecutive winter terms (2018/19, 2019/20) and comprehensively evaluated based on the general course evaluations and an anonymous questionnaire covering aspects of content, layout and user friendliness of the TERMInator and questions concerning the students' learning preferences. RESULTS: The TERMInator was rated very positively overall, which was also fed back to the lecturers during the classes. Students appreciate the new e-learning tool greatly and stress that the TERMInator should be further expanded. The handling of the TERMInator was considered to be very easy and, therefore, almost no training time was needed. The tasks were easy to understand and considered a good supplement to the seminar contents. The extent and quality of the images were seen rather critically. The students' learning strategies differ. Although e-learning options were generally rated as very important, student tutorials were considered by far the most important. CONCLUSIONS: Medical terminology classes are characterised by heterogeneous learning groups and a high workload within a short time, which can lead to major challenges for the teaching staff. Complementary gamified e-learning tools are promising in view of the students' different knowledge levels and changing learning behaviour. TRIAL REGISTRATION: Not applicable.

Non-cross-reactive epitopes dominate the humoral immune response to COVID-19 vaccination - kinetics of plasma antibodies, plasmablasts and memory B cells.

Introduction: COVID-19 vaccines are highly effective in inducing protective immunity. While the serum antibody response to COVID-19 vaccination has been studied in depth, our knowledge of the underlying plasmablast and memory B cell (Bmem) responses is still incomplete. Here, we determined the antibody and B cell response to COVID-19 vaccination in a naïve population and contrasted it with the response to a single influenza vaccination in a primed cohort. In addition, we analyzed the antibody and B cell responses against the four endemic human coronaviruses (HCoVs). Methods: Measurement of specific plasma IgG antibodies was combined with functional analyses of antibody-secreting plasmablasts and Bmems. SARS-CoV-2- and HCoV-specific IgG antibodies were quantified with an in-house bead-based multiplexed immunoassay. Results: The antibody and B cell responses to COVID-19 vaccination reflected the kinetics of a prime-boost immunization, characterized by a slow and moderate primary response and a faster and stronger secondary response. In contrast, the influenza vaccinees possessed robust immune memory for the vaccine antigens prior to vaccination, and the recall vaccination moderately boosted antibody production and Bmem responses. Antibody levels and Bmem responses waned several months after the 2nd COVID-19 vaccination, but were restored upon the 3rd vaccination. The COVID-19 vaccine-induced antibodies mainly targeted novel, non-cross-reactive S1 epitopes of the viral spike protein, while cross-reactive S2 epitopes were less immunogenic. Booster vaccination not only strongly enhanced neutralizing antibodies against an original SARS-CoV-2 strain, but also induced neutralizing antibodies against the Omicron BA.2 variant. We observed a 100% plasma antibody prevalence against the S1 subunits of HCoVs, which was not affected by vaccination. Discussion: Overall, by complementing classical serology with a functional evaluation of plasmablasts and memory B cells we provide new insights into the specificity of COVID-19 vaccine-induced antibody and B cell responses.

On the latency of object recognition and affect: Evidence from speeded reaction time tasks.

According to the semantic primacy hypothesis of emotion generation, stimuli must be semantically categorized to evoke emotions. This hypothesis was tested in two speeded reaction time experiments that also explored the processes underlying valence judgments. Participants viewed pleasant and unpleasant pictures. In different blocks of trials, they pressed a key as soon as they experienced the feeling evoked by a picture, recognized the depicted object, or detected the valence (pleasant/unpleasant) of the picture. Object recognition was significantly earlier than affect onset, and the two latencies were positively correlated. The latency of valence detection was in between the latencies of object recognition and affect and correlated with both. Experiment 2 additionally found that blurring the pictures delayed the onset of affect and that this effect was partially mediated by delayed object recognition. In contrast, false-coloring the pictures was found to delay affect mainly by reducing its intensity. Coloring also delayed valence judgments of pleasant pictures. The findings provide further chronometric support for the semantic primacy hypothesis of emotion generation and shed light on the processes underlying valence judgments. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

On the latency of object recognition and affect: Evidence from temporal order and simultaneity judgments.

According to the semantic primacy hypothesis of emotion generation, stimuli must be semantically categorized to evoke emotions. This hypothesis was tested for the subjective component of emotions in four chronometric experiments in which the conscious recognition of emotion-eliciting objects and the onset of affect was timed using temporal order judgments (TOJs, Exp. 1a, 1b, and 3) and simultaneity judgments (SJs, Exp. 2). Participants viewed pictures that elicited pleasant or unpleasant feelings. At varying intervals before and after picture onset, a visual probe stimulus was presented. In separate blocks of trials, the participants judged when they recognized the object shown in the picture and noticed the feeling evoked by the picture: Before or after the probe (TOJs), or simultaneously/not simultaneously with the probe (SJs). Psychometric functions were fitted to the data of the individual participants to determine the point of subjective simultaneity (PSS) of the target events and the probe. In both tasks, the mean PSS of affect occurred significantly later than the PSS of object recognition, with an average delay of about 120 ms. A positive lag between object recognition and affect was found for nearly all participants and pictures. In addition, the latencies of object recognition and affect were positively correlated. The found temporal order of object recognition and affect is consistent with the findings of previous studies using speeded reaction time tasks. Implications of the findings for the cognition-emotion debate and for bodily feedback theories of emotional experience are discussed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Predicting Pro-environmental Intention and Behavior Based on Justice Sensitivity, Moral Disengagement, and Moral Emotions - Results of Two Quota-Sampling Surveys.

The effects of climate change lead to increasing social injustice and hence justice is intrinsically linked to a socio-ecological transformation. In this study, we investigate whether justice sensitivity motivates pro-environmental intention (PEI) and behavior (PEB) and, if so, to what extent emotions and moral disengagement determine this process. For this purpose, we conducted two quota-sampling surveys (Study 1: N = 174, Study 2: N = 880). Multiple regression analyses in both studies suggest that a higher perception of injustice from a perpetrator's, beneficiary's, and observer's perspective is associated with an increased PEI. However, moral disengagement best predicted PEB and PEI. Guilt and authentic pride were found to be emotional predictors of PEI. Additionally, mediation analyses demonstrated that guilt mediates the connection between both perpetrator and beneficiary sensitivity and PEI. These results suggest that when the predominant originators of climate change (i.e., individuals from industrialized countries) perceive global climate injustice from the perspective of a beneficiary or a perpetrator, they experience guilt and have a higher PEI. Based on this mechanism, it seems promising to render global injustice more salient to those responsible for activities that lead to climate change to motivate them to adapt their behavior. The role of moral disengagement and victim sensitivity as barriers to pro-environmental behavior is discussed in this context.

Perceptual latencies of object recognition and affect measured with the rotating spot method: Chronometric evidence for semantic primacy.

According to the semantic primacy hypothesis of emotion generation, stimuli must be semantically categorized to evoke emotions. This hypothesis was tested in two chronometric studies, using the rotating spot method of timing subjective events. Participants saw pleasant and unpleasant pictures while a spot rotated around the edge of the picture. In different blocks of trials, they indicated when they experienced the pleasant or unpleasant feeling evoked by the pictures, or recognized the depicted objects, by reporting the position of the spot at the time when these mental events occurred. In both experiments, the latency of object recognition was found to be shorter than the latency of affect for nearly all participants and pictures, and the two latencies were positively correlated across participants. Experiment 2 replicated these findings and additionally showed that an experimental manipulation that delayed object recognition, blurring the pictures, also delayed the onset of affect. A mediation analysis suggested that this effect was at least partly mediated by the delayed recognition of the objects. The findings support the semantic primacy hypothesis. (PsycInfo Database Record (c) 2022 APA, all rights reserved).