RESUMEN
OBJECTIVE: The aim of this work was to evaluate a pediatric ependymoma protein expression that may be useful as a molecular biomarker candidate for prognosis, correlated with clinical features such as age, gender, histopathological grade, ependymal tumor recurrence and patient survival. PATIENTS AND METHODS: Immunohistochemistry assays were performed for GNAO1, ASAH1, IMMT, IPO7, Cyclin D1, P53 and Ki-67 proteins. Kaplan-Meier and Cox analysis were performed for age, gender, histopathological grade, relapse and survival correlation. RESULTS: We found that three proteins correlate with histopathological grade and relapse; two proteins correlate with survival; one protein does not correlate with any clinical feature. CONCLUSION: Our results suggest that, out of the proteins analyzed, five may be considered suitable prognostic biomarkers and one may be considered a predictive biomarker for response to treatment of pediatric ependymoma.
Asunto(s)
Ceramidasa Ácida/biosíntesis , Neoplasias Encefálicas/metabolismo , Ependimoma/metabolismo , Subunidades alfa de la Proteína de Unión al GTP Gi-Go/biosíntesis , Carioferinas/biosíntesis , Proteínas Mitocondriales/biosíntesis , Proteínas Musculares/biosíntesis , Receptores Citoplasmáticos y Nucleares/biosíntesis , Ceramidasa Ácida/genética , Adolescente , Biomarcadores de Tumor/biosíntesis , Biomarcadores de Tumor/genética , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/genética , Niño , Preescolar , Estudios de Cohortes , Ependimoma/diagnóstico , Ependimoma/genética , Femenino , Subunidades alfa de la Proteína de Unión al GTP Gi-Go/genética , Regulación Neoplásica de la Expresión Génica , Humanos , Lactante , Recién Nacido , Carioferinas/genética , Masculino , Proteínas Mitocondriales/genética , Proteínas Musculares/genética , Pronóstico , Receptores Citoplasmáticos y Nucleares/genética , Factores de TiempoRESUMEN
Clear cell meningioma (CCM) is an uncommon meningioma. Some cases have been reported, and the localization of most of them is the spinal region. We present 3 cases of CCMs in the frontotemporal lobes. All cases were postmenopausal women with a history of arterial hypertension and uterine leiomyomatosis. The radiologic appearance in 2 cases was similar to that of dural hematomas, and in 1 case, the imaging study was consistent with the diagnosis of meningioma. On histologic examination, there were sheets of glycogenated polygonal cells with abundant clear cytoplasm and round, uniform, bland appearing nuclei. Numerous hyalinized blood vessels and collagenous stroma with fibrillary appearance were present in 2 cases. They were immunoreactive to epithelial membrane antigen, epithelial cell adhesion molecule, and progesterone receptors. However, 2 cases showed weak and focal reaction to Her-2/neu. In our knowledge, some cases of CCMs have been reported and no immunoexpression has been noted with those markers used. These cases illustrate a rare variant of meningioma in the frontotemporal lobes and their immunohistochemical profiles. Differential diagnosis is discussed.