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J Pharm Biomed Anal ; 176: 112798, 2019 Nov 30.
Artículo en Inglés | MEDLINE | ID: mdl-31394303

RESUMEN

PURPOSE: Salts of phenylacetic acid (PAA) and phenylbutyric acid (PBA) have been used for nitrogen elimination as a treatment for hyperammonaemia caused by urea cycle disorders (UCD). A new analytical method for PBA measurement in urine which helps to evaluate the drug adherence has been implemented. METHODS: Urine specimens from UCD patients receiving PBA were analysed by tandem mass spectrometry to measure urine phenylacetylglutamine (PAGln). Some clinical and biochemical data for each patient were collected. RESULTS: Our study included 87 samples from 40 UCD patients. The PAGln levels did not correlate with height, weight or age. However, the PAGln values showed correlation with PBA dose (r = 0.383, P = 0.015). Plasma glutamine and ammonia levels presented a positive correlation (r = 0.537, P < 0.001). The stability for PAGln in urine was determined at different storage temperatures. CONCLUSIONS: We have developed a simple method for the determination of PAGln in urine, which acts as useful biomarker of effective drug delivery. PAGln in urine is stable at room temperature at least for 15 days, and for several months when frozen at -20 °C. This procedure is useful for the optimization and monitorization of the drug dose allowing the use of spot urine samples.


Asunto(s)
Benzoatos/farmacocinética , Monitoreo de Drogas/métodos , Glutamina/análogos & derivados , Fenilbutiratos/farmacocinética , Trastornos Innatos del Ciclo de la Urea/tratamiento farmacológico , Adolescente , Adulto , Benzoatos/uso terapéutico , Biomarcadores/orina , Niño , Preescolar , Cromatografía Líquida de Alta Presión/métodos , Femenino , Glutamina/metabolismo , Glutamina/orina , Humanos , Lactante , Recién Nacido , Masculino , Cumplimiento de la Medicación , Fenilbutiratos/uso terapéutico , Espectrometría de Masas en Tándem/métodos , Trastornos Innatos del Ciclo de la Urea/orina , Adulto Joven
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