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1.
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.
Bioorg Med Chem Lett
; 24(12): 2635-9, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24813737
2.
Discovery of Potent and Selective Covalent Inhibitors of HER2WT and HER2YVMA.
J Med Chem
; 67(11): 9759-9771, 2024 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38820338
3.
A next-generation BRAF inhibitor overcomes resistance to BRAF inhibition in patients with BRAF-mutant cancers using pharmacokinetics-informed dose escalation.
Cancer Discov
; 2024 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38691346
4.
Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.
Toxicol Appl Pharmacol
; 266(1): 86-94, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23142475
5.
SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.
Cancer Discov
; 13(8): 1789-1801, 2023 08 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-37269335
6.
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.
J Med Chem
; 63(13): 6679-6693, 2020 07 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32250617
7.
Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
ACS Med Chem Lett
; 9(12): 1230-1234, 2018 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30613331
8.
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.
J Med Chem
; 59(12): 5650-60, 2016 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27227380
9.
Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.
J Med Chem
; 58(4): 1976-91, 2015 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25603482
10.
Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists.
Bioorg Med Chem Lett
; 14(22): 5537-42, 2004 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15482919
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