Polychromatic Dual-Mode Imaging with Structured Chiral Photonic Crystals.

Optical spatial differentiation is a typical operation of optical analog computing and can single out the edge to accelerate the subsequent image processing, but in some cases, overall information about the object needs to be presented synchronously. Here, we propose a multifunctional optical device based on structured chiral photonic crystals for the simultaneous realization of real-time dual-mode imaging. This optical differentiator is realized by self-organized large-birefringence cholesteric liquid crystals, which are photopatterned to encode with a special integrated geometric phase. Two highly spin-selective modes of second-order spatial differentiation and bright-field imaging are exhibited in the reflected and transmitted directions, respectively. Two-dimensional edges of both amplitude and phase objects have been efficiently enhanced in high contrast and the broadband spectrum. This work extends the ingenious building of hierarchical chiral nanostructures, enriches their applications in the emerging frontiers of optical computing, and boasts considerable potential in machine vision and microscopy.

Ultralow-power all-optical switching via a chiral Mach-Zehnder interferometer.

It is a challenge for all-optical switching to simultaneous achieve ultralow power consumption, broad bandwidth and high extinction ratio. We experimentally demonstrate an ultralow-power all-optical switching by exploiting chiral interaction between light and optically active material in a Mach-Zehnder interferometer. We achieve switching extinction ratio of 20.0 ± 3.8 and 14.7 ± 2.8 dB with power cost of 66.1 ± 0.7 and 1.3 ± 0.1 fJ/bit, respectively. The bandwidth of our all-optical switching is about 4.2 GHz. Moreover, our all-optical switching has the potential to be operated at few-photon level. Our scheme paves the way towards ultralow-power and ultrafast all-optical information processing.

Transflective spatial terahertz wave modulator.

Spatial light modulators can digitally manipulate the amplitude, phase, and polarization of light. Their counterparts in the terahertz band are highly pursued to meet the requirements of numerous applications such as wireless communications and biomedical detection. Here, we propose a spatial terahertz wave modulator based on a liquid-crystal-integrated metadevice. The modulator consists of 8 × 8 pixels. The liquid crystal layer is sandwiched between an asymmetric split ring resonator array and pixelated interdigital electrodes. Fano resonance occurs for the transmitted wave, while the reflected wave is perfectly absorbed. By separately driving the liquid crystal with pixelated interdigital electrodes, both the Fano resonance and absorption peak can be continuously tuned due to the variation in the environmental refractive index. This work provides a transflective spatial terahertz wave modulator that can dynamically reconfigure a terahertz wavefront.

Liquid crystal integrated metalens with dynamic focusing property.

Metalenses are developing fast towards versatile and integrated terahertz (THz) apparatuses, while tunable ones are highly pursued. Here, we propose a strategy that integrates dielectric metasurfaces with liquid crystals (LCs) to realize the dynamic focal spot manipulation. The silicon pillar meta-units of the metasurface are properly selected to generate different phase profiles for two orthogonal linear polarizations, permitting a laterally or axially altered focal spot. After LCs integrated, polarization-multiplexed focusing can be achieved via electrically varying the LC orientations. We demonstrate two metalenses with distinct functions. For the first one, the uniformly aligned LC works as a polarization converter, and further switches the focal length by altering the bias. For the second one, an LC polarization grating is utilized for rear spin-selective beam deflection. Consequently, a THz port selector is presented. This work supplies a promising method towards active THz elements, which may be widely applied in THz sensing, imaging, and communication.

Liquid crystal tunable terahertz lens with spin-selected focusing property.

We propose and demonstrate an active spin-selected lens with liquid crystal (LC) in the terahertz (THz) range. The lens is a superposition of two geometric phase lenses with separate centers and conjugated phase profiles. Its digitalized multidirectional LC orientations are realized via a dynamic micro-lithography-based photo-patterning technique and sandwiched by two graphene-electrode-covered silica substrates. The specific lens can separate the focusing spots of incident light with opposite circular polarizations. Its focusing performance from 0.8 to 1.2 THz is characterized using a scanning near-field THz microscope system. The polarization conversion efficiency varies from 32.1% to 70.2% in this band. The spin-selected focusing functions match well with numerical simulations. Such lens exhibits the merit of dynamic functions, low insertion loss and broadband applicability. It may inspire various practical THz apparatuses.

Liquid-crystal-integrated metadevice: towards active multifunctional terahertz wave manipulations.

Active terahertz elements with multifunction are highly expected in security screening, nondestructive evaluation, and wireless communications. Here, we propose an innovative terahertz metadevice that exhibits distinguishing functions for transmitted and reflected waves. The device is composed of a thin liquid crystal layer sandwiched by Au comb electrodes and a dual-ring resonator array. For transmission mode, the metadevice manifests the electromagnetically induced transparency analog. For reflection mode, it works as a perfect absorber. The comb electrodes actuate the in-plane switching of liquid crystals, making the metadevice actively tuned. 60 GHz frequency tuning of an electromagnetically induced transparency analog and 15% modulation depth of the absorption are demonstrated. Such modulations can be realized in the millisecond scale. The in-plane switching driving mode avoids the electrode connections among separate resonators, thus freeing the design of the metadevice. The proposed work may pave a bright road towards various active multifunctional terahertz apparatuses.

Graphene-assisted high-efficiency liquid crystal tunable terahertz metamaterial absorber.

In this paper, few-layer porous graphene is integrated onto the surface of a metasurface layer to provide a uniform static electric field to efficiently control liquid crystal, thereby enabling flexible metamaterial designs. We demonstrate a tunable cross-shaped metamaterial absorber with different arm lengths driven by this combined metasurface and graphene electrode. The resulting absorber supports a resonant frequency tunable from 0.75 to 1 THz with a high-quality factor, and amplitude modulation of ~80% at these frequencies with an applied voltage of 10 V. Furthermore, the near-field intensity and hot spot distribution can be manipulated over a broad range.

Terahertz vortex beam generator based on a photopatterned large birefringence liquid crystal.

A terahertz (THz) q-plate is proposed and demonstrated to generate THz vortex beams. It is composed of a large birefringence liquid crystal (LC) with spatially-varying director distribution sandwiched by two pieces of fused silica glass. A polarization-sensitive alignment agent is photopatterned to carry out the specific LC director distribution. THz vortex beams with different topological charges are characterized with a THz digital holographic imaging system. The intensity and phase distributions consistent with theoretical analyses are obtained. Besides, an eight-lobed intensity distribution is observed corresponding to the vertical polarization component of a cylindrical vector beam. This work may inspire novel THz applications.

Helicity-dependent forked vortex lens based on photo-patterned liquid crystals.

A liquid crystal forked vortex lens integrated with Pancharatnam-Berry phase is proposed and demonstrated via a dynamic photo-patterning technique. The forked vortex lens can generate two optical vortices with opposite spin and orbital angular momentum, which are spatially separated to two focal points with one optical vortex focused and the other defocused. It exhibits distinctive helicity-dependency and ultra-high diffraction efficiency up to 95%. The topological charges of generated optical vortices are detected via astigmatic transformation. This work supplies an easy fabrication and low power consumption strategy for generating and separating (de-)focused optical vortices simultaneously.

[Analysis of clinical phenotype and genotype of unstable Hemoglobin Rush].

OBJECTIVE: To analyze the hematological and genetic characteristics of unstable hemoglobin Rush (Hb Rush) and compound heterozygote of Hb Rush and thalassemia. METHODS: Peripheral blood samples and genomic DNA from three patients (including two ethnic Dai and one Han Chinese) with anemia of undetermined origin were collected. Hematological phenotypes of these patients were determined through red blood cell analysis and hemoglobin electrophoresis. Genotypes of alpha- and beta-globin genes, -158 XmnⅠ polymorphic site of Gγ promoter region, and haplotypes of 7 polymorphic restriction sites in the beta-globin gene cluster were determined using PCR-based methods and DNA sequencing. RESULTS: All patients have presented hypochromic microcytic anemia and hemoglobin fraction with significant increased measurement (30.5%-59.2%) in the region of fetal hemoglobin during alkaline medium electrophoresis. DNA analysis suggested that all patients have carried mutations leading to the unstable hemoglobin Rush (HBB codon 101, GAG>CAG, Glu>Gln). Two of them were compound heterozygotes of Hb Rush and thalassemia mutations of -α 3.7,CD17 and Hb E, respectively. Hb Rush mutation was associated with various haplotypes of the ß-globin gene cluster. No significant association was found between increased abnormal hemoglobin fraction in the region of Hb F and the polymorphism of Gγ promoter or large deletion of the beta-globin gene cluster. CONCLUSION: This study has confirmed the distribution of Hb Rush among various Chinese populations and is the third report of its kind. Hb Rush can result in increased measurement of hemoglobin fraction in the region of fetal hemoglobin (Hb F) during routine hemoglobin electrophoresis under alkaline condition. Hb Rush heterozygote alone can lead to hypochromic microcytic anemia and thalassemia-like phenotype. Prenatal diagnosis of Hb Rush is necessary for carriers.

"Hot-wire" microfluidic flowmeter based on a microfiber coupler.

Using an optical microfiber coupler (MC), we present a microfluidic platform for strong direct or indirect light-liquid interaction by wrapping a MC around a functionalized capillary. The light propagating in the MC and the liquid flowing in the capillary can be combined and divorced smoothly, keeping a long-distance interaction without the conflict of input and output coupling. Using this approach, we experimentally demonstrate a "hot-wire" microfluidic flowmeter based on a gold-integrated helical MC device. The microfluid inside the glass channel takes away the heat, then cools the MC and shifts the resonant wavelength. Due to the long-distance interaction and high temperature sensitivity, the proposed microfluidic flowmeter shows an ultrahigh flow rate sensitivity of 2.183 nm/(µl/s) at a flow rate of 1 µl/s. The minimum detectable change of the flow rate is around 9 nl/s at 1 µl/s.

Simulation and optimization of liquid crystal gratings with alternate twisted nematic and planar aligned regions.

Electro-optical properties of liquid crystal (LC) gratings with alternate twisted nematic (TN) and planar aligned (PA) regions are simulated. Three typical steps are introduced: first, the LC director distributions of the two different regions are simulated. Then, the phase and amplitude of the emergent light in each region are calculated through Jones matrix. Based on this information, the voltage-dependent diffraction efficiency is achieved by Fourier transformation, finally. It gives an exact explanation for the mechanism of this kind of gratings. Experiments with optimized parameters are carried out through photopatterning. The trend of the measured voltage-dependent efficiency fits the simulation result very well. This method can be used to optimize the performance of LC gratings with alternate TN and PA regions, and exhibits great potential in the simulation of corresponding photonics and display applications.

Logical rotation of non-separable states via uniformly self-assembled chiral superstructures.

The next generation of high-capacity, multi-task optical informatics requires sophisticated manipulation of multiple degrees of freedom (DoFs) of light, especially when they are coupled in a non-separable way. Vector beam, as a typical non-separable state between the spin and orbital angular momentum DoFs, mathematically akin to entangled qubits, has inspired multifarious theories and applications in both quantum and classical regimes. Although qubit rotation is a vital and ubiquitous operation in quantum informatics, its classical analogue is rarely studied. Here, we demonstrate the logical rotation of vectorial non-separable states via the uniform self-assembled chiral superstructures, with favorable controllability, high compactness and exemption from formidable alignment. Photonic band engineering of such 1D chiral photonic crystal renders the incident-angle-dependent evolution of the spatially-variant polarizations. The logical rotation angle of a non-separable state can be tuned in a wide range over 4π by this single homogeneous device, flexibly providing a set of distinguished logic gates. Potential applications, including angular motion tracking and proof-of-principle logic network, are demonstrated by specific configuration. This work brings important insight into soft matter photonics and present an elegant strategy to harness high-dimensional photonic states.

Electrical tuning of branched flow of light.

Branched flows occur ubiquitously in various wave systems, when the propagating waves encounter weak correlated scattering potentials. Here we report the experimental realization of electrical tuning of the branched flow of light using a nematic liquid crystal (NLC) system. We create the physical realization of the weakly correlated disordered potentials of light via the inhomogeneous orientations of the NLC. We demonstrate that the branched flow of light can be switched on and off as well as tuned continuously through the electro-optical properties of NLC film. We further show that the branched flow can be manipulated by the polarization of the incident light due to the optical anisotropy of the NLC film. The nature of the branched flow of light is revealed via the unconventional intensity statistics and the rapid fidelity decay along the light propagation. Our study unveils an excellent platform for the tuning of the branched flow of light which creates a testbed for fundamental physics and offers a new way for steering light.

Pancharatnam-Berry phase reversal via opposite-chirality-coexisted superstructures.

Recently discovered reflective Pancharatnam-Berry phase (PB phase) from chiral anisotropic media (e.g., cholesteric liquid crystal, CLC) has aroused great interest in the emerging frontier of planar optics. However, the single chirality of common CLCs results in the intrinsic limitation of the same spin-selective PB phase manipulation, which means the reversal of the input spin cannot realize the conjugated PB phase. In this work, an innovative scheme based on opposite-chirality-coexisted superstructures is proposed to simultaneously modulate orthogonal circular polarization and get PB phase reversal. Through refilling CLC into a washed-out polymer network with opposite chirality and delicate photo-patterned structures, reflective optical vortex (OV) with opposite topological charges and vector beams with conjugated spiral PB phases are efficiently generated depending on the incident polarization. Furthermore, OV holograms are encoded to reconstruct polarization-selective OV arrays, indicating the strong capability of such opposite-chirality-coexisted anisotropic media. This work provides a new compact platform for planar optics, and sheds light on the architectures and functionalities of chiral superstructures.

Programmable self-propelling actuators enabled by a dynamic helical medium.

Rotation-translation conversion is a popular way to achieve power transmission in machinery, but it is rarely selected by nature. One unique case is that of bacteria swimming, which is based on the collective reorganization and rotation of flagella. Here, we mimic such motion using the light-driven evolution of a self-organized periodic arch pattern. The range and direction of translation are altered by separately varying the alignment period and the stimulating photon energy. Programmable self-propelling actuators are realized via a specific molecular assembly within a photoresponsive cholesteric medium. Through rationally presetting alignments, parallel transports of microspheres in customized trajectories are demonstrated, including convergence, divergence, gathering, and orbital revolution. This work extends the understanding of the rotation-translation conversion performed in an exquisitely self-organized system and may inspire future designs for functional materials and intelligent robotics.

Interactions of unstable hemoglobin Rush with thalassemia and hemoglobin E result in thalassemia intermedia.

Background: The clinical consequences and significance of many unstable hemoglobins interacting with other hemoglobinopathies remain unrecognized. Here we first explore molecular and hematological characterizations of previously undescribed compound heterozygosity states for unstable hemoglobin Rush (Hb Rush, Beta 101 Glu > Gln, HBB:c.304G > C) with Hb E and different forms of thalassemia. Methods: Hematological assays, globin gene mutation assays and ß-globin gene cluster haplotype were conducted in 11 patients from 8 unrelated Chinese ethnic families with unexplained hemoglobin separation fraction in hemoglobin gel electrophoresis. Results: Hb Rush in various combinations with Hb E, ß0-thalassemias and α+-thalassemia were identified. Hb Rush simple heterozygote was generally associated with mild hemolytic anemia, and the compound heterozygotes of Hb Rush and the other ß-globin variants led to thalassemia intermedia phenotypes with moderate anemia. Hemoglobin electrophoreses showed that the co-presence of Hb Rush with either Hb E or ß0-thalassemias increased proportion of Hb Rush due to relative decrease of other globin chain synthesis. Beta-globin gene cluster haplotype analysis suggested a common origin of the Hb Rush variant in the Chinese families of different ethnic ancestry. Conclusions: Unstable Hb Rush interacting with ß-thalassemia result in thalassemia intermedia phenotypes, which demonstrated the clinical significance of Hb Rush and new insights into complex mechanism of clinical heterogeneity of thalassemia.

Chirality invertible superstructure mediated active planar optics.

Active planar optical devices that can dynamically manipulate light are highly sought after in modern optics and nanophotonics. The geometric phase derived from the photonic spin-orbit interaction provides an integrated strategy. Corresponding elements usually suffer from static functions. Here, we introduce an inhomogeneously self-organized anisotropic medium featured by photo-invertible chiral superstructure to realize geometric phase elements with continuously tunable working spectrum and light-flipped phase profile. Via preprograming the alignment of a cholesteric liquid crystal mixed with a photo-responsive chiral dopant, we demonstrate light-activated deflector, lens, Airy beam and optical vortex generators. Their polychromatic working bands are reversibly tuned in an ultra-broadband over 1000 nm covering green to telecomm region. The chirality inversion triggers facile switching of functionalities, such as beam steering, focusing/defocusing and spin-to-orbital angular momentum conversion. This work offers a platform for advanced adaptive and multifunctional flat optics with merits of high compactness, low loss and broad bandwidth.

[Phenotype Analysis of 78 Cases of Abnormal Hemoglobin E Homozygotes].

OBJECTIVE: To analyze the hematological characteristics of HbE homozygotes. METHODS: Complete blood cells count and hemoglobin electrophoresis were used for phenotypic analysis of 78 cases with HbE homozygotes from Yunnan province, China. The PCR-fluorescence hybridization was used to detect the common gene mutation of thalassemia. The hematological indexes, including MCV, MCH, Hb, HbA2, HbF and HbE were statistically analyzed between groups with different sex, ages and compound α thalassemia status. RESULTS: In HbE homozygotes (HbEE), 89.5% (17/19) children presented mild to moderate microcytic hypochromic anemia, and 10.5% of them presented moderate anemia. 39.6% (19/48) of women with HbEE developed mild anemia ,while 11 cases of male with HbE homozygotes were asymptomatic. The levels of MCV and MCH in HbE homozygotes increased by co-inheritance of α thalassemia mutation. CONCLUSION: The clinical phenotype of HbE homozygote shows highly heterogeneous, which is relates with age, sex and co-inheriting α-globin genotypes. In Hb EE women and children are more likely to develop mild to moderate anemia. The microcytic hypochromic anemia degree is relieved when HbEE combined with α- thalassemia.

Digitalizing Self-Assembled Chiral Superstructures for Optical Vortex Processing.

Cholesteric liquid crystal (CLC) chiral superstructures exhibit unique features; that is, polychromatic and spin-determined phase modulation. Here, a concept for digitalized chiral superstructures is proposed, which further enables the arbitrary manipulation of reflective geometric phase and may significantly upgrade existing optical apparatus. By encoding a specifically designed binary pattern, an innovative CLC optical vortex (OV) processor is demonstrated. Up to 25 different OVs are extracted with equal efficiency over a wavelength range of 116 nm. The multiplexed OVs can be detected simultaneously without mode crosstalk or distortion, permitting a polychromatic, large-capacity, and in situ method for parallel OV processing. Such complex but easily fabricated self-assembled chiral superstructures exhibit versatile functionalities, and provide a satisfactory platform for OV manipulation and other cutting-edge territories. This work is a vital step towards extending the fundamental understanding and fantastic applications of ordered soft matter.