RESUMEN
The neurodevelopmental model of schizophrenia, which posits that the illness is the end state of abnormal neurodevelopmental processes that started years before the illness onset, is widely accepted, and has long been dominant for childhood-onset neuropsychiatric disorders. This selective review updates our 2005 review of recent studies that have impacted, or have the greatest potential to modify or extend, the neurodevelopmental model of schizophrenia. Longitudinal whole-population studies support a dimensional, rather than categorical, concept of psychosis. New studies suggest that placental pathology could be a key measure in future prenatal high-risk studies. Both common and rare genetic variants have proved surprisingly diagnostically nonspecific, and copy number variants (CNVs) associated with schizophrenia are often also associated with autism, epilepsy and intellectual deficiency. Large post-mortem gene expression studies and prospective developmental multi-modal brain imaging studies are providing critical data for future clinical and high-risk developmental brain studies. Whether there can be greater molecular specificity for phenotypic characterization is a subject of current intense study and debate, as is the possibility of neuronal phenotyping using human pluripotent-inducible stem cells. Biological nonspecificity, such as in timing or nature of early brain development, carries the possibility of new targets for broad preventive treatments.
Asunto(s)
Encéfalo/crecimiento & desarrollo , Modelos Neurológicos , Esquizofrenia/etiología , Factores de Edad , Encéfalo/patología , Predisposición Genética a la Enfermedad/genética , Humanos , Neuroimagen/métodos , Neuroimagen/psicología , Células Madre Pluripotentes/patología , Factores de Riesgo , Esquizofrenia/genética , Esquizofrenia/patologíaRESUMEN
Disrupted-in-schizophrenia-1 (DISC1), contains two common non-synonymous single-nucleotide polymorphisms (SNPs)--Leu607Phe and Ser704Cys--that modulate (i) facets of DISC1 molecular functioning important for cortical development, (ii) fronto-temporal cortical anatomy in adults and (iii) risk for diverse psychiatric phenotypes that often emerge during childhood and adolescence, and are associated with altered fronto-temporal cortical development. It remains unknown, however, if Leu607Phe and Ser704Cys influence cortical maturation before adulthood, and whether each SNP shows unique or overlapping effects. Therefore, we related genotype at Leu607Phe and Ser704Cys to cortical thickness (CT) in 255 typically developing individuals aged 9-22 years on whom 598 magnetic resonance imaging brain scans had been acquired longitudinally. Rate of cortical thinning varied with DISC1 genotype. Specifically, the rate of cortical thinning was attenuated in Phe-carrier compared with Leu-homozygous groups (in bilateral superior frontal and left angular gyri) and accelerated in Ser-homozygous compared with Cys-carrier groups (in left anterior cingulate and temporal cortices). Both SNPs additively predicted fixed differences in right lateral temporal CT, which were maximal between Phe-carrier/Ser-homozygous (thinnest) vs Leu-homozygous/Cys-carrier (thickest) groups. Leu607Phe and Ser704Cys genotype interacted to predict the rate of cortical thinning in right orbitofrontal, middle temporal and superior parietal cortices, wherein a significantly reduced rate of CT loss was observed in Phe-carrier/Cys-carrier participants only. Our findings argue for further examination of Leu607Phe and Ser704Cys interactions at a molecular level, and suggest that these SNPs might operate (in concert with other genetic and environmental factors) to shape risk for diverse phenotypes by impacting on the early maturation of fronto-temporal cortices.
Asunto(s)
Desarrollo del Adolescente/fisiología , Corteza Cerebral/crecimiento & desarrollo , Desarrollo Infantil/fisiología , Proteínas del Tejido Nervioso/fisiología , Polimorfismo de Nucleótido Simple/fisiología , Adolescente , Corteza Cerebral/anatomía & histología , Niño , Femenino , Genotipo , Humanos , Imagen por Resonancia Magnética , Masculino , Proteínas del Tejido Nervioso/genética , Neuroimagen/métodos , Neuroimagen/estadística & datos numéricos , Adulto JovenRESUMEN
Structural maturation of fiber tracts in the human brain, including an increase in the diameter and myelination of axons, may play a role in cognitive development during childhood and adolescence. A computational analysis of structural magnetic resonance images obtained in 111 children and adolescents revealed age-related increases in white matter density in fiber tracts constituting putative corticospinal and frontotemporal pathways. The maturation of the corticospinal tract was bilateral, whereas that of the frontotemporal pathway was found predominantly in the left (speech-dominant) hemisphere. These findings provide evidence for a gradual maturation, during late childhood and adolescence, of fiber pathways presumably supporting motor and speech functions.
Asunto(s)
Envejecimiento , Encéfalo/crecimiento & desarrollo , Vías Nerviosas/crecimiento & desarrollo , Adolescente , Axones/fisiología , Axones/ultraestructura , Encéfalo/anatomía & histología , Mapeo Encefálico , Niño , Preescolar , Femenino , Lóbulo Frontal/anatomía & histología , Lóbulo Frontal/crecimiento & desarrollo , Humanos , Imagen por Resonancia Magnética , Masculino , Destreza Motora , Vaina de Mielina/ultraestructura , Fibras Nerviosas/ultraestructura , Conducción Nerviosa , Vías Nerviosas/anatomía & histología , Análisis de Regresión , Habla , Médula Espinal/anatomía & histología , Transmisión Sináptica , Lóbulo Temporal/anatomía & histología , Lóbulo Temporal/crecimiento & desarrolloRESUMEN
Structural magnetic resonance imaging data from 308 twins, 64 singleton siblings of twins, and 228 singletons were analyzed using structural equation modeling and selected multivariate methods to identify genetically mediated intracortical associations. Principal components analyses (PCA) of the genetic correlation matrix indicated a single factor accounting for over 60% of the genetic variability in cortical thickness. When covaried for mean global cortical thickness, PCA, cluster analyses, and graph models identified genetically mediated fronto-parietal and occipital networks. Graph theoretical models suggest that the observed genetically mediated relationships follow small world architectural rules. These findings are largely concordant with other multivariate studies of brain structure and function, the twin literature, and current understanding on the role of genes in cortical neurodevelopment.
Asunto(s)
Corteza Cerebral/fisiología , Análisis Multivariante , Red Nerviosa/fisiología , Hermanos , Gemelos/fisiología , Adolescente , Mapeo Encefálico/métodos , Niño , Preescolar , Femenino , Humanos , Estudios Longitudinales , Masculino , Gemelos/genéticaAsunto(s)
Catecol O-Metiltransferasa/genética , Corteza Cerebral/anatomía & histología , Metionina/genética , Polimorfismo Genético/genética , Valina/genética , Adolescente , Distribución de Chi-Cuadrado , Niño , Lateralidad Funcional/genética , Genotipo , Humanos , Imagen por Resonancia Magnética/métodos , MasculinoRESUMEN
BACKGROUND: Adolescence provides a window to examine regional and disease-specific late abnormal brain development in schizophrenia. Because previous data showed progressive brain ventricular enlargement for a group of adolescents with childhood-onset schizophrenia at 2-year follow-up, with no significant changes for healthy controls, we hypothesized that there would be a progressive decrease in volume in other brain tissue in these patients during adolescence. METHODS: To examine cortical change, we used anatomical brain magnetic resonance imaging scans for 15 patients with childhood-onset schizophrenia (defined as onset of psychosis by age 12 years) and 34 temporally yoked, healthy adolescents at a mean (SD) age of 13.17 (2.73) years at initial baseline scan and 17.46 (2.96) years at follow-up scan. Cortical gray and white matter volumes were obtained with an automated analysis system that classifies brain tissue into gray matter, white matter, and cerebrospinal fluid and separates the cortex into anatomically defined lobar regions. RESULTS: A significant decrease in cortical gray matter volume was seen for healthy controls in the frontal (2.6%) and parietal (4.1%) regions. For the childhood-onset schizophrenia group, there was a decrease in volume in these regions (10.9% and 8.5%, respectively) as well as a 7% decrease in volume in the temporal gray matter. Thus, the childhood-onset schizophrenia group showed a distinctive disease-specific pattern (multivariate analysis of variance for change X region X diagnosis: F, 3.68; P = .004), with the frontal and temporal regions showing the greatest between-group differences. Changes in white matter volume did not differ significantly between the 2 groups. CONCLUSIONS: Patients with very early-onset schizophrenia had both a 4-fold greater decrease in cortical gray matter volume during adolescence and a disease-specific pattern of change. Etiologic models for these patients' illness, which seem clinically and neurobiologically continuous with later-onset schizophrenia, must take into account both early and late disruptions of brain development.
Asunto(s)
Corteza Cerebral/anatomía & histología , Imagen por Resonancia Magnética , Esquizofrenia Infantil/diagnóstico , Adolescente , Edad de Inicio , Corteza Cerebral/crecimiento & desarrollo , Ventrículos Cerebrales/anatomía & histología , Ventrículos Cerebrales/crecimiento & desarrollo , Niño , Femenino , Humanos , Estudios Longitudinales , MasculinoRESUMEN
BACKGROUND: Anatomic studies of boys with attention-deficit/hyperactivity disorder (ADHD) have detected decreased volumes in total and frontal brain, basal ganglia, and cerebellar vermis. We tested these findings in a sample of girls with ADHD. METHODS: Anatomic brain magnetic resonance images from 50 girls with ADHD, of severity comparable with that in previously studied boys, and 50 healthy female control subjects, aged 5 to 15 years, were obtained with a 1.5-T scanner with contiguous 2-mm coronal slices and 1.5-mm axial slices. We measured volumes of total cerebrum, frontal lobes, caudate nucleus, globus pallidus, cerebellum, and cerebellar vermis. Behavioral measures included structured psychiatric interviews, parent and teacher ratings, and the Wechsler vocabulary and block design subtests. RESULTS: Total brain volume was smaller in girls with ADHD than in control subjects (effect size, 0.40; P =.05). As in our previous study in boys with ADHD, girls with ADHD had significantly smaller volumes in the posterior-inferior cerebellar vermis (lobules VIII-X; effect size, 0.54; P =.04), even when adjusted for total cerebral volume and vocabulary score. Patients and controls did not differ in asymmetry in any region. Morphometric differences correlated significantly with several ratings of ADHD severity and were not predicted by past or present stimulant drug exposure. CONCLUSIONS: These results confirm previous findings for boys in the posterior-inferior lobules of the cerebellar vermis. The influence of the cerebellar vermis on prefrontal and striatal circuitry should be explored.
Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Encéfalo/anatomía & histología , Imagen por Resonancia Magnética/estadística & datos numéricos , Adolescente , Trastorno por Déficit de Atención con Hiperactividad/epidemiología , Núcleo Caudado/anatomía & histología , Cerebelo/anatomía & histología , Niño , Trastornos de la Conducta Infantil/diagnóstico , Trastornos de la Conducta Infantil/epidemiología , Comorbilidad , Femenino , Lóbulo Frontal/anatomía & histología , Lateralidad Funcional , Globo Pálido/anatomía & histología , Humanos , Masculino , Escalas de Valoración Psiquiátrica/estadística & datos numéricos , Factores Sexuales , Escalas de Wechsler/estadística & datos numéricosRESUMEN
BACKGROUND: Anatomic magnetic resonance imaging (MRI) studies of attention-deficit hyperactivity disorder (ADHD) have been limited by small samples or measurement of single brain regions. Since the neuropsychological deficits in ADHD implicate a network linking basal ganglia and frontal regions, 12 subcortical and cortical regions and their symmetries were measured to determine if these structures best distinguished ADHD. METHODS: Anatomic brain MRIs for 57 boys with ADHD and 55 healthy matched controls, aged 5 to 18 years, were obtained using a 1.5-T scanner with contiguous 2-mm sections. Volumetric measures of the cerebrum, caudate nucleus, putamen, globus pallidus, amygdala, hippocampus, temporal lobe, cerebellum; a measure of prefrontal cortex; and related right-left asymmetries were examined along with midsagittal area measures of the cerebellum and corpus callosum. Interrater reliabilities were .82 or greater for all MRI measures. RESULTS: Subjects with ADHD had a 4.7% smaller total cerebral volume (P = .02). Analysis of covariance for total cerebral volume demonstrated a significant loss of normal right > left asymmetry in the caudate (P = .006), smaller right globus pallidus (P = .005), smaller right anterior frontal region (P = .02), smaller cerebellum (P = .05), and reversal of normal lateral ventricular asymmetry (P = .03) in the ADHD group. The normal age-related decrease in caudate volume was not seen, and increases in lateral ventricular volumes were significantly diminished in ADHD. CONCLUSION: This first comprehensive morphometric analysis is consistent with hypothesized dysfunction of right-sided prefrontal-striatal systems in ADHD.
Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Encéfalo/anatomía & histología , Imagen por Resonancia Magnética , Adolescente , Factores de Edad , Ganglios Basales/anatomía & histología , Estatura , Peso Corporal , Núcleo Caudado/anatomía & histología , Cerebelo/anatomía & histología , Ventrículos Cerebrales/anatomía & histología , Niño , Preescolar , Análisis Discriminante , Lóbulo Frontal/anatomía & histología , Lateralidad Funcional , Globo Pálido/anatomía & histología , Humanos , Pruebas de Inteligencia , Masculino , Corteza Prefrontal/anatomía & histologíaRESUMEN
BACKGROUND: Early-onset schizophrenia (first psychotic symptoms by age 12 years) has been the subject of a small number of studies, and its biological continuity with later-onset disorder has not been established. In this study quantitative anatomic brain magnetic resonance images of children and adolescents with early-onset schizophrenia were compared with those of matched controls. Brain abnormalities in childhood-onset schizophrenia were examined in relation to those reported for later-onset schizophrenics. METHODS: Anatomic brain magnetic resonance imaging scans were obtained for 21 patients (mean +/- SD age, 14.6 +/- 2.1 years; range, 10 to 18 years) with childhood-onset schizophrenia (13 males, eight females) and 33 age-, sex-, height-, and weight-matched normal controls. Quantitative measurements were obtained for the cerebrum, anterior frontal region, lateral ventricles, thalamus, caudate, putamen, and globus pallidus. RESULTS: Total cerebral volume and midsagittal thalamic area were smaller in the patients (analysis of variance, P = .002, and analysis of covariance, P = .03, respectively); the caudate, putamen, and globus pallidus were larger in the patients (analysis of covariance, P = .05, P = .007, and P < .001, respectively); and the lateral ventricles tended to be larger in the patients (analysis of covariance, P = .06). Globus pallidus enlargement correlated with neuroleptic exposure and with age of onset of psychosis. The magnitude of abnormalities compared with controls was similar to that reported in adult studies, although there was a trend toward relatively smaller cerebral volumes for the childhood-onset group compared with controls. CONCLUSION: Brain anatomic abnormalities in childhood-onset schizophrenia are similar to those reported for adult populations, indicating overall continuity between these rare childhood cases and the adult schizophrenia populations.
Asunto(s)
Encéfalo/anatomía & histología , Imagen por Resonancia Magnética , Esquizofrenia Infantil/diagnóstico , Adolescente , Adulto , Edad de Inicio , Núcleo Caudado/anatomía & histología , Ventrículos Cerebrales/anatomía & histología , Niño , Globo Pálido/anatomía & histología , Humanos , Putamen/anatomía & histología , Tálamo/anatomía & histologíaRESUMEN
Several lines of evidence have implicated central dopaminergic pathways in the modulation of blink rate. In the present study, blink rate during smooth pursuit was examined in 17 children with childhood-onset schizophrenia, on and off of clozapine, and compared to that of age-matched normal children and unmedicated children with attention-deficit hyperactivity disorder (ADHD). As has been observed in adolescent and adult schizophrenics, blink rate was significantly higher in schizophrenic children relative to normal and ADHD controls. Within the schizophrenic group, blink rate did not significantly change with the introduction of clozapine and was not related to clinical variables. Blink rate was positively correlated with deterioration in smooth pursuit in normal subjects.
Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/psicología , Parpadeo/fisiología , Esquizofrenia Infantil/psicología , Adolescente , Conducta del Adolescente , Adulto , Niño , Conducta Infantil , Cognición/fisiología , Movimientos Oculares/fisiología , Femenino , Humanos , Masculino , Escalas de Valoración Psiquiátrica , Seguimiento Ocular Uniforme/fisiología , Psicología del EsquizofrénicoRESUMEN
BACKGROUND: Previous investigations suggest that maltreated children with a diagnosis of posttraumatic stress disorder (PTSD) evidence alterations of biological stress systems. Increased levels of catecholaminergic neurotransmitters and steroid hormones during traumatic experiences in childhood could conceivably adversely affect brain development. METHODS: In this study, 44 maltreated children and adolescents with PTSD and 61 matched controls underwent comprehensive psychiatric and neuropsychological assessments and an anatomical magnetic resonance imaging (MRI) brain scan. RESULTS: PTSD subjects had smaller intracranial and cerebral volumes than matched controls. The total midsagittal area of corpus callosum and middle and posterior regions remained smaller; while right, left, and total lateral ventricles were proportionally larger than controls, after adjustment for intracranial volume. Brain volume robustly and positively correlated with age of onset of PTSD trauma and negatively correlated with duration of abuse. Symptoms of intrusive thoughts, avoidance, hyperarousal or dissociation correlated positively with ventricular volume, and negatively with brain volume and total corpus callosum and regional measures. Significant gender by diagnosis effect revealed greater corpus callosum area reduction in maltreated males with PTSD and a trend for greater cerebral volume reduction than maltreated females with PTSD. The predicted decrease in hippocampal volume seen in adult PTSD was not seen in these subjects. CONCLUSIONS: These data suggest that the overwhelming stress of maltreatment experiences in childhood is associated with adverse brain development.
Asunto(s)
Encéfalo/anatomía & histología , Maltrato a los Niños/estadística & datos numéricos , Imagen por Resonancia Magnética , Trastornos por Estrés Postraumático/diagnóstico , Adolescente , Adulto , Factores de Edad , Edad de Inicio , Encéfalo/crecimiento & desarrollo , Encéfalo/fisiopatología , Catecolaminas/fisiología , Niño , Maltrato a los Niños/diagnóstico , Abuso Sexual Infantil/diagnóstico , Abuso Sexual Infantil/estadística & datos numéricos , Comorbilidad , Cuerpo Calloso/anatomía & histología , Cuerpo Calloso/crecimiento & desarrollo , Estudios Transversales , Femenino , Hipocampo/anatomía & histología , Hipocampo/crecimiento & desarrollo , Humanos , Hidrocortisona/fisiología , Imagen por Resonancia Magnética/estadística & datos numéricos , Masculino , Trastornos Mentales/diagnóstico , Trastornos Mentales/epidemiología , Escalas de Valoración Psiquiátrica/estadística & datos numéricos , Factores Sexuales , Trastornos por Estrés Postraumático/epidemiologíaRESUMEN
Abnormalities of the smooth pursuit eye movements of adults with schizophrenia have been well described. We examined smooth pursuit eye movements in schizophrenic children, contrasting them with normal and attention-deficit hyperactivity disorder (ADHD) subjects, to determine whether there is continuity of eye movement dysfunction between childhood- and adult-onset forms of schizophrenia. Seventeen schizophrenic children with onset of illness by age 12, 18 ADHD children, and 22 normal children were studied while engaged in a smooth pursuit eye tracking task. Eye tracking variables were compared across the three groups. Schizophrenic children exhibited significantly greater smooth pursuit impairments than either normal or ADHD subjects. Within the schizophrenic group, there were no significant relationships between eye tracking variables and clinical variables, or ventricular/brain ratio. Childhood-onset schizophrenia is associated with a similar pattern of smooth pursuit abnormalities to that seen in later-onset schizophrenia.
Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/psicología , Seguimiento Ocular Uniforme/fisiología , Esquizofrenia Infantil/psicología , Adolescente , Trastorno por Déficit de Atención con Hiperactividad/patología , Encéfalo/patología , Ventrículos Cerebrales/patología , Niño , Cognición/fisiología , Método Doble Ciego , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Escalas de Valoración Psiquiátrica , Desempeño Psicomotor/fisiología , Esquizofrenia Infantil/patología , Psicología del EsquizofrénicoRESUMEN
BACKGROUND: Previous NIMH childhood onset schizophrenia (COS) anatomic brain MRI studies found progression of ventricular volume and other structural brain anomalies at 2-year follow up across mean ages 14 to 16 years. However, studies in adult patients generally do not show progression of ventricular volume or correlation of ventricular volume with duration of illness. To address issues of progression of brain anomalies in schizophrenia, this report extends previous studies to include a third longitudinal scan, uses a larger sample size, and includes measures of the amygdala and hippocampus. METHODS: Volumes of the total cerebrum, lateral ventricles, hippocampus, and amygdala were quantified on 208 brain magnetic resonance imaging scans from 42 adolescents with COS (23 with one or more repeat scan) and 74 age- and gender-matched controls (36 with one or more repeat scan). A statistical technique permitting combined use of cross-sectional and longitudinal data was used to assess age-related changes, linearity, and diagnostic group differences. RESULTS: Differential nonlinear progression of brain anomalies was seen during adolescence with the total cerebrum and hippocampus decreasing and lateral ventricles increasing in the COS group. The developmental curves for these structures reached an asymptote by early adulthood for the COS group and did not significantly change with age in the control group. CONCLUSIONS: These findings reconcile less striking progression of anatomic brain images usually seen for adult schizophrenia and complement other data consistent with time-limited, diagnostic-specific decreases in brain tissue. Adolescence appears to be a unique period of differential brain development in schizophrenia.
Asunto(s)
Encéfalo/anomalías , Imagen por Resonancia Magnética , Trastornos Neurocognitivos/diagnóstico , Esquizofrenia Infantil/diagnóstico , Adolescente , Adulto , Amígdala del Cerebelo/anomalías , Amígdala del Cerebelo/patología , Encéfalo/patología , Corteza Cerebral/anomalías , Corteza Cerebral/patología , Ventrículos Cerebrales/anomalías , Ventrículos Cerebrales/patología , Niño , Estudios Transversales , Progresión de la Enfermedad , Femenino , Hipocampo/anomalías , Hipocampo/patología , Humanos , Estudios Longitudinales , MasculinoRESUMEN
OBJECTIVE: Deficits in dopaminergic function may contribute to hypertrophy of striatal structures associated with typical neuroleptic treatment. In light of a body of research that has associated chronic cocaine use with extrapyramidal symptoms and striatal dopaminergic depletion, the authors looked for evidence of striatal dysmorphology in patients with chronic cocaine dependence. METHOD: Caudate, putamen, and total brain volumes were quantified by means of magnetic resonance imaging in 25 cocaine-dependent and 20 healthy subjects. RESULTS: Normalized caudate and putamen volumes were 3.40% and 9.18% larger, respectively, in the cocaine-dependent subjects. CONCLUSIONS: These observations suggest that deficits in dopaminergic function associated with cocaine dependence may contribute to striatal hypertrophy.
Asunto(s)
Núcleo Caudado/anatomía & histología , Trastornos Relacionados con Cocaína/diagnóstico , Putamen/anatomía & histología , Adulto , Encéfalo/anatomía & histología , Trastornos Relacionados con Cocaína/patología , Trastornos Relacionados con Cocaína/fisiopatología , Cuerpo Estriado/patología , Dopamina/fisiología , Femenino , Humanos , Hipertrofia , Imagen por Resonancia Magnética/estadística & datos numéricos , Masculino , Persona de Mediana EdadRESUMEN
OBJECTIVE: The purpose of this study was to examine the relationships between clinical and neurobiological measures of childhood-onset schizophrenia. It was hypothesized that there would be a more striking pattern in the rare cases with very early onset than is seen in subjects with later onset. METHOD: Premorbid, clinical, prenatal, perinatal, and magnetic resonance imaging brain measures were examined in 29 children and adolescents who met the DSM-III-R criteria for schizophrenia with onset before age 12. Specifically, gender, premorbid adjustment, and clinical symptoms were examined in relation to cerebral volume, ventricular volume, and maternal obstetrical complications. RESULTS: Males were more likely to have had an insidious onset than females. There was a significant negative correlation between score on the Scale for the Assessment of Negative Symptoms and total cerebral volume. CONCLUSIONS: These neurobiological associations support the continuity of early-onset schizophrenia with the later-onset disorder; the striking association between smaller cerebral volume and negative symptoms suggests a more homogeneous or more potent neurobiological basis for very early-onset schizophrenia.
Asunto(s)
Encéfalo/anatomía & histología , Esquizofrenia Infantil/diagnóstico , Adolescente , Edad de Inicio , Biomarcadores , Niño , Trastornos Generalizados del Desarrollo Infantil/diagnóstico , Trastornos Generalizados del Desarrollo Infantil/epidemiología , Comorbilidad , Femenino , Humanos , Trastornos del Lenguaje/diagnóstico , Trastornos del Lenguaje/epidemiología , Imagen por Resonancia Magnética , Embarazo , Complicaciones del Embarazo/epidemiología , Escalas de Valoración Psiquiátrica , Esquizofrenia Infantil/epidemiología , Esquizofrenia Infantil/psicología , Factores Sexuales , Ajuste SocialRESUMEN
OBJECTIVE: The authors assessed selective basal ganglia involvement in a subgroup of children with obsessive-compulsive disorder (OCD) and/or tics believed to be associated with streptococcal infection. METHOD: Using computer-assisted morphometric techniques, they analyzed the cerebral magnetic resonance images of 34 children with presumed streptococcus-associated OCD and/or tics and 82 healthy comparison children who were matched for age and sex. RESULTS: The average sizes of the caudate, putamen, and globus pallidus, but not of the thalamus or total cerebrum, were significantly greater in the group of children with streptococcus-associated OCD and/or tics than in the healthy children. The differences were similar to those found previously for subjects with Sydenham's chorea compared with normal subjects. CONCLUSIONS: These results support the hypothesis that there is a distinct subgroup of subjects with OCD and/or tics who have enlarged basal ganglia. These findings are consistent with the hypothesis of an autoimmune response to streptococcal infection.
Asunto(s)
Ganglios Basales/anatomía & histología , Imagen por Resonancia Magnética , Trastorno Obsesivo Compulsivo/diagnóstico , Infecciones Estreptocócicas/complicaciones , Tics/diagnóstico , Enfermedades Autoinmunes/etiología , Autoinmunidad , Ganglios Basales/inmunología , Encéfalo/anatomía & histología , Núcleo Caudado/anatomía & histología , Niño , Corea/diagnóstico , Corea/etiología , Corea/inmunología , Femenino , Globo Pálido/anatomía & histología , Humanos , Masculino , Trastorno Obsesivo Compulsivo/etiología , Trastorno Obsesivo Compulsivo/inmunología , Putamen/anatomía & histología , Infecciones Estreptocócicas/inmunología , Tálamo/anatomía & histología , Tics/etiología , Tics/inmunologíaRESUMEN
OBJECTIVE: Patients with schizophrenia have been reported to have a higher frequency of enlarged cavum septi pellucidi (CSP) in comparison with normal subjects. Neurodevelopmental models of schizophrenia suggest that the more severe the brain dysgenesis, the earlier the onset of psychotic symptoms. Study of patients with childhood-onset schizophrenia allows the opportunity to test this hypothesis. METHOD: Two groups of subjects were evaluated: healthy volunteers (N=95, mean age=11.7 years) and patients with childhood-onset schizophrenia (N=24, mean age=14.6 years). Magnetic resonance images of 1-mm resampled contiguous brain slices were rated blind to diagnosis. The size of the CSP was recorded as the number of consecutive slices in which the CSP was present. Abnormal enlargement was defined as a CSP greater than 6 mm in length. RESULTS: The frequency of an enlarged CSP was significantly higher in the patient group: 12.5% (three of 24 subjects) versus 1.1% (one of 95 subjects). Also, two of the three patients with an enlarged CSP had complete nonfusion of the septal leaflets, a more severe anomaly than was found in the one comparison subject with an enlarged CSP and typically more severe than anomalies seen in groups with adult-onset schizophrenia. CONCLUSIONS: These findings suggest that patients with extremely early-onset (childhood) forms of schizophrenia may have more severe developmental brain anomalies than those with adult onset.
Asunto(s)
Esquizofrenia Infantil/patología , Tabique Pelúcido/anomalías , Adolescente , Adulto , Factores de Edad , Edad de Inicio , Niño , Humanos , Imagen por Resonancia Magnética , Esquizofrenia/diagnóstico , Esquizofrenia/patología , Esquizofrenia Infantil/diagnóstico , Tabique Pelúcido/patología , Índice de Severidad de la EnfermedadRESUMEN
OBJECTIVE: Because the caudate nuclei receive inputs from cortical regions implicated in executive functioning and attentional tasks, caudate and total brain volumes were examined in boys with attention deficit hyperactivity disorder (ADHD) and normal comparison subjects. To gain developmental perspective, a wide age range was sampled for both groups. METHOD: The brains of 50 male ADHD patients (aged 6-19) and 48 matched comparison subjects were scanned by magnetic resonance imaging (MRI). Volumetric measures of the head and body of the caudate nucleus were obtained from T1-weighted coronal images. Interrater reliabilities (intraclass correlations) were 0.89 or greater. RESULTS: The normal pattern of slight but significantly greater right caudate volume across all ages was not seen in ADHD. Mean right caudate volume was slightly but significantly smaller in the ADHD patients than in the comparison subjects, while there was no significant difference for the left. Together these facts accounted for the highly significant lack of normal asymmetry in caudate volume in the ADHD boys. Total brain volume was 5% smaller in the ADHD boys, and this was not accounted for by age, height, weight, or IQ. Smaller brain volume in ADHD did not account for the caudate volume or symmetry differences. For the normal boys, caudate volume decreased substantially (13%) and significantly with age, while in ADHD there was no age-related change. CONCLUSIONS: Along with previous MRI findings of low volumes in corpus callosum regions, these results support developmental abnormalities of frontal-striatal circuits in ADHD.
Asunto(s)
Trastorno por Déficit de Atención con Hiperactividad/diagnóstico , Núcleo Caudado/anatomía & histología , Adulto , Factores de Edad , Estatura , Peso Corporal , Encéfalo/anatomía & histología , Niño , Desarrollo Infantil/fisiología , Cuerpo Calloso/anatomía & histología , Lateralidad Funcional , Humanos , Pruebas de Inteligencia , Imagen por Resonancia Magnética , MasculinoRESUMEN
OBJECTIVE: Although childhood-onset schizophrenia is rare, children with brief psychotic symptoms and prominent emotional disturbances commonly present diagnostic and treatment problems. Quantitative anatomic brain magnetic resonance images (MRIs) of a subgroup of children with psychotic disorder not otherwise specified were compared with those of children with childhood-onset schizophrenia and healthy comparison subjects. METHOD: Anatomic MRIs were obtained for 71 patients (44 with childhood-onset schizophrenia and 27 with psychotic disorder not otherwise specified) and 106 healthy volunteers. Most patients had been treated with neuroleptics. Volumetric measurements for the cerebrum, anterior frontal region, lateral ventricles, corpus callosum, caudate, putamen, globus pallidus, and midsagittal thalamic area were obtained. RESULTS: Patients had a smaller total cerebral volume than healthy comparison subjects. Analysis of covariance for total cerebral volume and age found that lateral ventricles were larger in both patient groups than in healthy comparison subjects and that schizophrenia patients had a smaller midsagittal thalamic area than both subjects with psychotic disorder not otherwise specified and healthy comparison subjects. CONCLUSIONS: Pediatric patients with psychotic disorder not otherwise specified showed a pattern of brain volumes similar to those found in childhood-onset schizophrenia. Neither group showed a decrease in volumes of temporal lobe structures. Prospective longitudinal magnetic resonance imaging and clinical follow-up studies of both groups are currently underway to further validate the distinction between these two disorders.
Asunto(s)
Encéfalo/anatomía & histología , Imagen por Resonancia Magnética/estadística & datos numéricos , Trastornos Psicóticos/diagnóstico , Esquizofrenia/diagnóstico , Adolescente , Factores de Edad , Edad de Inicio , Análisis de Varianza , Niño , Diagnóstico Diferencial , Femenino , Lateralidad Funcional , Humanos , MasculinoRESUMEN
OBJECTIVE: By means of quantitative neuroanatomic imaging the authors assessed the hypothesis that there are structural brain abnormalities relevant to frontal lobe circuitry in children with attention deficit hyperactivity disorder (ADHD). METHOD: The midsagittal cross-sectional area of the corpus callosum, divided into seven sections, was measured from magnetic resonance images of 18 boys with ADHD and 18 carefully matched normal boys. RESULTS: Two anterior regions, the rostrum and the rostral body, were found to have significantly smaller areas in the ADHD group. These areas correlated in the expected direction with teacher and parent ratings of hyperactivity/impulsivity. CONCLUSIONS: This finding supports theories of abnormal frontal lobe development and function in ADHD.