RESUMEN
Observing others is an important means of gathering information by proxy regarding safety and danger, a form of learning that is available as early as infancy. In two experiments, we examined the specificity and retention of emotional eavesdropping (i.e., bystander learning) on cue-specific discriminant learning during toddlerhood. After witnessing one adult admonish another for playing with Toy A (with no admonishment for Toy B), toddlers learned to choose Toy B for themselves regardless of whether they were tested immediately or 2 weeks later (Experiment 1). However, if asked to make a toy choice for someone else (i.e., when toddlers' personal risk was lower), approximately half the toddlers instead selected Toy A (Experiment 2). However, such choices were accompanied by toddlers' social monitoring of the adults, suggesting that toddlers may have been attempting to safely gain (via surrogacy) more information about risk contingencies. These findings suggest that toddlers can learn to discriminate valence in a cue-specific manner through social observation.
Asunto(s)
Señales (Psicología) , Aprendizaje , Adulto , Preescolar , Emociones , HumanosRESUMEN
BACKGROUND: The purpose of this study was to describe the pre- and postsurgical opioid prescription rates and average morphine milligram equivalents (MME) per day in patients undergoing total shoulder replacement (TSR) procedures. METHODS: Patients undergoing TSR were identified from the electronic health records (EMR). In addition to patient demographics, opioid prescription 12-months presurgery and postsurgery were recorded. Patients were categorized into two groups: patients with no opioid prescriptions within 12 months before surgery and patients with an opioid prescription after surgery. McNemar tests were conducted to test for significant presurgical to postsurgical changes in opioid rate changes. The Wilcoxon signed rank test was used to test for significant pre- to postsurgical changes in average MME/day/person, and bivariate logistic regression analyses and covariate-adjusted logistic regressions were used to predict postsurgical opioid prescriptions. RESULTS: Overall, 1,076 patients underwent TSR. More than 900 patients received presurgical opioid prescriptions. There was a significant increase (p = .0015) in pre-surgical to postsurgical prescription rates. Postsurgical opioid prescriptions were 4.6 times more likely to be prescribed to a pre-surgical non-opioid patient than an opioid patient (p < .0001). Among those prescribed an opioid, the median dosage was <50 MME/day and over 82% of patients were at low overdose risk. Patients with comorbidities and without pre-surgical alcohol use were more likely to receive postsurgical opioids. Postsurgical opioid prescriptions were 4.6 times more likely to be prescribed to a presurgical non-opioid patient than an opioid patient (p < .0001). More than 80% of patients undergoing TSR received presurgical opioids. Among those prescribed any opioid, the median dosage was <50 MME/day and greater than 82% of patients were at low overdose risk. CONCLUSIONS: Although presurgical non-opioid patients were more likely to receive a postsurgical opioid prescription, based on dosage, most patients were at low risk for an opioid-related overdose or death according to CDC guidelines.
Asunto(s)
Artroplastía de Reemplazo de Hombro , Sobredosis de Droga , Analgésicos Opioides/uso terapéutico , Humanos , Dolor Postoperatorio/tratamiento farmacológico , Pautas de la Práctica en Medicina , Estudios RetrospectivosRESUMEN
Hearing loss is prevalent in the geriatric population. Healthcare systems and providers are challenged to meet communication needs in hearing impaired adults in the acute care setting. Patients with impaired-hearing pose risk to themselves and the healthcare system. Healthcare systems can utilize the expertise of advanced practice nurses, especially those with a geriatric focus to develop strategic imperatives aimed at addressing the unique needs of older adults patients with hearing impairments. Instituting a practice change using the personal amplifier device for older adult patients with hearing impairment is an innovative approach to enhancing effective communication and care delivery between patients and the healthcare interprofessional team. Innovative strategies include understanding personal amplifier devices, developing methods to identify patients who present with hearing loss, and provide interdisciplinary education and training to providers. Advanced practice nurses are ideal to function as change agents in the improvement of care for the hearingimpaired older adult.
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Pérdida Auditiva , Anciano , Comunicación , Atención a la Salud , Audición , Pérdida Auditiva/epidemiología , Pérdida Auditiva/terapia , Humanos , Grupo de Atención al PacienteRESUMEN
BACKGROUND: The trauma burden in South Africa is significant. The objective of this project was to investigate the incidence of posttrauma pulmonary complications (PPCs) and to identify patient, health risks, and hospital factors, which predispose trauma patients to develop PPCs hospital in Pietermaritzburg, South Africa. METHODS: The design was a retrospective secondary data analysis of patients who presented as a trauma admission via the health systems' Hybrid Electronic Medical Registry. The final data set included 6382 trauma admissions. RESULTS: The PPC rate was 9.4% for patients with a surgical intervention versus 1.9% for those without a surgical intervention. Of the total 289 PPCs reported, the most common included pneumonia or atelectasis (46.4%) and prolonged ventilation (36.0%). The risk of developing a PPC was statistically significantly (P < 0.0001) associated with surgical intervention and the number of surgeries. CONCLUSIONS: The trauma burden in South Africa requires complex medical and surgical interventions. The incidence of PPCs is significantly associated with surgical intervention. With the increasing demand to harness data and improve patient care, the Hybrid Electronic Medical Registry proves to be a driver for quality improvement.
Asunto(s)
Análisis de Datos , Enfermedades Pulmonares/etiología , Heridas y Lesiones/complicaciones , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Recuperación Mejorada Después de la Cirugía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neumonía/etiología , Atelectasia Pulmonar/etiología , Estudios Retrospectivos , Factores de Riesgo , Adulto JovenRESUMEN
This article discusses skill proficiency of providers related to emergency cricothyroidotomies. Various techniques to improve procedural skills were studied. Accurate identification of the cricothyroid membrane via palpation remained consistently inadequate. High-fidelity simulation including the use of human cadavers may be the preferred method of skill training for crisis management. The authors emphasize that additional research is needed regarding a method for rapid cricothyroid membrane identification as well as needle cricothyroidotomy versus surgical airway on cadavers. More consistent training will enable emergency care providers to perform this rare but lifesaving skill.
Asunto(s)
Enfermería de Cuidados Críticos , Servicios Médicos de Urgencia , Entrenamiento Simulado , Tiroidectomía , Competencia Clínica , Cartílago Cricoides , Cuidados Críticos , HumanosRESUMEN
PURPOSE: Stress-induced hyperglycemia during the perioperative period is associated with adverse outcomes after spinal surgery, which increases both patient-related burden and hospital costs. This quality improvement project describes the development and implementation of a perioperative blood glucose monitoring protocol for patients undergoing spinal surgery. DESIGN: An evidence-based perioperative blood glucose monitoring protocol was developed by a multidisciplinary committee of specialists in endocrinology and anesthesiology with utilization of the American Diabetes Association diabetes screening criteria. METHODS: The protocol was implemented in the perioperative areas of a regional hospital in the Southeastern United States. The project sample included patients with and without a prior diagnosis of diabetes who met protocol inclusion criteria during a 3-month implementation period. FINDINGS: Preoperative glycated hemoglobin (HbA1c) testing identified more than 54% of previously undiagnosed patients with levels consistent with either prediabetes or diabetes according to the American Diabetes Association criteria for diagnosis. Patients with diabetes and those without diabetes experienced a perioperative increase in blood glucose with levels remaining elevated above preoperative baseline through postoperative day 1. CONCLUSIONS: A perioperative blood glucose monitoring protocol enables preoperative identification of patients with undiagnosed prediabetes and diabetes, allowing for optimization before elective surgery and establishment of appropriate postoperative follow-up care. In addition, a blood glucose monitoring protocol increases the detection of perioperative hyperglycemia and may lead to a reduction in postoperative complications after spinal surgery.
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Glucemia/análisis , Protocolos Clínicos , Monitoreo Fisiológico/métodos , Anciano , Femenino , Hemoglobina Glucada/análisis , Humanos , Masculino , Persona de Mediana Edad , Monitoreo Fisiológico/instrumentación , Enfermería Perioperatoria/métodos , Periodo Perioperatorio , Complicaciones Posoperatorias/prevención & control , Sudeste de Estados UnidosRESUMEN
Undiagnosed obstructive sleep apnea (OSA) may adversely impact surgical patients and can lead to increased morbidity and mortality during the perioperative period, especially among the geriatric patient population (Chung et al. 2008, 2012, 2014; McDonald et al., 2018; Zietlow et al., 2018; Singh et al., 2012). The setting of this quality improvement project was a preoperative anesthesia and geriatric evaluation clinic housed within a 957-bed tertiary academic affiliated hospital. The sample included 45 patients who met the criteria established for surgery and OSA screening preoperatively. Nine patients (20.0%) were assessed as low risk (Stop-bang [SB] score =2) for OSA, and 36 patients (80.0%) had a prior diagnosis from an ICD-9/10 code or a SB score >/= 3 indicative of high-risk for OSA. The retrospective utilization of a modified SB screening on charts that did not receive a clinical OSA evaluation (nâ¯=â¯52) detected 23 (44.2%) patients who were considered high-risk for OSA but were not identified prior to surgery. The SB questionnaire is underutilized, and patients' OSA is often unidentified prior to surgery.
Asunto(s)
Geriatría , Tamizaje Masivo , Periodo Preoperatorio , Apnea Obstructiva del Sueño/diagnóstico , Encuestas y Cuestionarios , Anciano , Anestesia/efectos adversos , Cognición , Femenino , Humanos , Masculino , Mejoramiento de la Calidad , Estudios Retrospectivos , Procedimientos Quirúrgicos OperativosRESUMEN
PURPOSE: A presurgical pregnancy testing protocol is recommended to prevent the administration of surgery and anesthesia to women of childbearing years who present for surgery with an undetected pregnancy. It is important to determine the compliance, cost analysis, time required, and barriers to complete a presurgical pregnancy testing protocol. DESIGN: Postimplementation qualitative and quantitative evaluation of a presurgical pregnancy protocol. METHODS: A review of the patient's electronic medical record, survey of the nursing staff, and an administrative interview was conducted 1 year after implementation of the presurgical pregnancy protocol. FINDINGS: Overall presurgical pregnancy protocol compliance was 0.7%. The total labor and equipment costs were $19,033 to $30,202 per year. Nurses reported significant time- and patient-related barriers to execute the protocol. CONCLUSIONS: A pregnancy testing protocol is a valuable safety measure that faces barriers, which can impede compliance. Through the use of simplified protocols, educational interventions for patients and providers, protocol compliance can be increased.
Asunto(s)
Procedimientos Quirúrgicos Ambulatorios/métodos , Tamizaje Masivo/métodos , Tamizaje Masivo/normas , Adulto , Procedimientos Quirúrgicos Ambulatorios/normas , Gonadotropina Coriónica/análisis , Gonadotropina Coriónica/sangre , Femenino , Humanos , Persona de Mediana Edad , North Carolina , Embarazo , Cuidados Preoperatorios/métodos , Cuidados Preoperatorios/normas , Investigación Cualitativa , Encuestas y CuestionariosRESUMEN
PURPOSE: The purpose of this project was to implement and evaluate the effectiveness of a postanesthesia care unit (PACU) obstructive sleep apnea (OSA) protocol in patients undergoing spinal fusion surgery. DESIGN: The structure of this project was a preimplementation and postimplementation design. METHODS: A convenience sample of 63 patients admitted to the PACU after spinal fusion surgery, with diagnosed or high-risk OSA, was included in protocol implementation. FINDINGS: The prevalence of diagnosed and high-risk OSA at the project implementation site totaled 74% in the spinal fusion population. The incidence of oxygen desaturations was 41% in the preimplementation group and 35% in the postimplementation group. The PACU to intensive care unit transfers were 10% in the preimplementation group and 3% in the postimplementation group. CONCLUSIONS: Protocols for surgical patients with OSA require further examination but may function as a guide for postoperative nursing care.
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Desarrollo de Programa/métodos , Apnea Obstructiva del Sueño/enfermería , Fusión Vertebral/enfermería , Anciano , Protocolos Clínicos , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Enfermería Posanestésica/métodos , Cuidados Posoperatorios , Complicaciones Posoperatorias/enfermería , Complicaciones Posoperatorias/prevención & control , Mejoramiento de la Calidad , Fusión Vertebral/efectos adversos , Fusión Vertebral/estadística & datos numéricos , Encuestas y CuestionariosRESUMEN
PURPOSE: Postoperative nausea and vomiting (PONV) is one of the most common complications after anesthesia. This evidence-based quality improvement (QI) project describes the implementation of a PONV guideline and the impact on providers' compliance with PONV risk assessment using the Apfel PONV score. DESIGN: A retrospective preimplementation and postimplementation QI project. METHODS: This evidence-based QI project sample included 294 adult female patients scheduled for gynecologic or breast surgery in the ambulatory setting. They were observed for PONV in the postanesthesia care unit. In addition, compliance of Apfel risk-assessment score documentation on the preanesthesia evaluation form was assessed. FINDINGS: Postimplementation of the guideline, the overall incidence of PONV was significantly lower (9.5% vs 21.1%, P = .009) and anesthesia providers' adherence to Apfel risk score documentation significantly increased (63.3% vs 49%, P = .019). CONCLUSIONS: A PONV guideline for gynecologic and breast surgery can reduce the PONV incidence and improve anesthesia providers' compliance with PONV risk assessment and its documentation.
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Procedimientos Quirúrgicos Ambulatorios/métodos , Anestesia/métodos , Náusea y Vómito Posoperatorios/prevención & control , Guías de Práctica Clínica como Asunto , Adulto , Mama/cirugía , Femenino , Adhesión a Directriz , Procedimientos Quirúrgicos Ginecológicos/métodos , Humanos , Incidencia , Persona de Mediana Edad , Náusea y Vómito Posoperatorios/epidemiología , Mejoramiento de la Calidad , Sala de Recuperación , Estudios Retrospectivos , Medición de Riesgo/métodosRESUMEN
PURPOSE: The purpose of this project was to determine whether the use of the modified Northwestern high risk spine protocol in patients undergoing multilevel spinal fusion surgery would result in improved transfusion practices. DESIGN: Preimplementation and postimplementation design. METHODS: A laboratory monitoring and transfusion guideline protocol was implemented in patients undergoing multilevel spinal fusions. Data were collected via a manual retrospective chart review of the electronic medical record before and after implementation of the protocol. FINDINGS: Laboratory values were monitored at guided intervals. There was a statistically significant (P = .004) decrease in the mean hemoglobin value at which a packed red blood cell transfusion was initiated. CONCLUSIONS: Through the use of the protocol, laboratory value monitoring provided quantitative data to aid and improve clinical decision making for practitioners in the perioperative period.
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Técnicas de Laboratorio Clínico/métodos , Atención de Enfermería/métodos , Fusión Vertebral/métodos , Anciano , Técnicas de Laboratorio Clínico/normas , Técnicas de Laboratorio Clínico/estadística & datos numéricos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Atención de Enfermería/normas , Atención de Enfermería/estadística & datos numéricos , Fusión Vertebral/estadística & datos numéricosRESUMEN
PURPOSE: Obstructive sleep apnea (OSA) affects an estimated 20% of the adult surgical population. Veteran patients have many characteristics consistent with OSA, but lack of standardized screening results in decreased detection of patients at risk for OSA. DESIGN: Pre-post implementation design. METHODS: Preanesthesia clinic providers were educated about OSA and the STOP-Bang questionnaire. Chart reviews evaluating screening and patient demographics were conducted before and after intervention. FINDINGS: Thirty-one percent of patients had an established diagnosis of OSA. Compliance rates with preoperative STOP-Bang screening were 91.3%. Of patients screened preoperatively, 44% were at risk for OSA with a STOP-Bang score of 4 or greater. CONCLUSIONS: The prevalence of patients among the Veteran population with and at risk for OSA is higher than the general population. Utilization of the STOP-Bang questionnaire as a standardized preoperative screening tool in preanesthesia clinics can increase the identification of patients at risk for OSA.
Asunto(s)
Tamizaje Masivo/métodos , Cuidados Preoperatorios/métodos , Apnea Obstructiva del Sueño/diagnóstico , Veteranos , Anciano , Femenino , Adhesión a Directriz , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Apnea Obstructiva del Sueño/epidemiología , Encuestas y CuestionariosRESUMEN
PURPOSE: Obstructive sleep apnea (OSA) is a breathing disorder found in surgical patients and associated with complications in the postoperative period. The implementation of a preoperative universal screening process using the STOP-BANG questionnaire to identify patients at high risk for OSA provides opportunities for improved management. DESIGN: A pre-post design was used to evaluate screening compliance rates. METHODS: This initiative included staff education, which included the process for evaluating and documenting STOP-BANG scores. The data were collected via a chart review of the electronic medical record (EMR). FINDINGS: The rate of screening for OSA doubled after implementation of this initiative, and compliance with STOP-BANG questionnaire screening was 66.1%. High-risk designation in the EMR was 73.0%. Nearly half of the patients screened were found to be at high risk for OSA. CONCLUSIONS: Implementation of a universal screening initiative for patients and design for the EMR improves compliance with screening and identification of patients at high risk for OSA.
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Registros Electrónicos de Salud , Tamizaje Masivo/métodos , Cuidados Preoperatorios/métodos , Apnea Obstructiva del Sueño/diagnóstico , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Apnea Obstructiva del Sueño/complicaciones , Encuestas y CuestionariosRESUMEN
The purpose of this article is to describe changes in hospital readmissions and costs for US hospital patients who underwent total knee replacement (TKR) in 2009 and 2014. Data came from the Healthcare Cost and Utilization Project net-Nationwide Readmissions Database. Compared with 2009, overall 30-day rates of readmissions after TKR decreased by 15% in 2014. Rates varied by demographics: readmission rates were lower for younger patients, males, Medicare recipients, and those with higher incomes. Overall, costs rose 20% across TKR groups. This report is among the first to describe changes in hospital readmissions and costs for TKR patients in a national sample of US acute care hospitals. Findings offer hospital managers a mechanism to benchmark their facilities' performances.
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Artroplastia de Reemplazo de Rodilla , Gastos en Salud/estadística & datos numéricos , Administradores de Hospital , Readmisión del Paciente , Factores de Edad , Anciano , Artroplastia de Reemplazo de Rodilla/economía , Artroplastia de Reemplazo de Rodilla/tendencias , Estudios Transversales , Bases de Datos Factuales , Femenino , Investigación sobre Servicios de Salud , Administradores de Hospital/economía , Administradores de Hospital/estadística & datos numéricos , Humanos , Tiempo de Internación/economía , Tiempo de Internación/estadística & datos numéricos , Masculino , Medicare/estadística & datos numéricos , Persona de Mediana Edad , Readmisión del Paciente/economía , Readmisión del Paciente/estadística & datos numéricos , Estudios Retrospectivos , Factores Sexuales , Estados UnidosRESUMEN
OBJECTIVE: To document changes in 30-day hospital readmission rates and causes for returning to the hospital for care in THR patients. DESIGN: Retrospective cross-sectional descriptive design. SETTING: Community-based acute care hospitals. PARTICIPANTS: Total sample size (N=142,022) included THR patients (identified as ICD-9-CM procedure code 81.51) in 2009 (n=31,232) and (n=32,863) in 2014. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: 30-Day hospital readmission. RESULTS: The overall readmission rate decreased by 1.3% from 2009 to 2014. The decrease in readmission rates varied by groups, with lesser improvements seen in THR patients who were younger, with private insurance, and residing in lower-income and rural communities. Device complications were the leading cause of readmission in THR patients, increasing from 19.8% in 2009 to 23.9% in 2014. CONCLUSIONS: There has been little decrease in hospital 30-day readmission rates for US community hospitals between 2009 and 2014. Findings from this brief report indicate patient groups at greater risk for 30-day hospital readmission as well as leading causes for readmission in THR patients which can inform the development of tailored interventions for reduction.
Asunto(s)
Artroplastia de Reemplazo de Cadera/estadística & datos numéricos , Readmisión del Paciente/estadística & datos numéricos , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Estudios Transversales , Femenino , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/epidemiología , Características de la Residencia/estadística & datos numéricos , Estudios Retrospectivos , Factores de Riesgo , Factores Socioeconómicos , Estados Unidos , Adulto JovenRESUMEN
Thorough documentation is essential for hospital reimbursement from payors such as the Centers for Medicare & Medicaid Services. Inconsistencies and incomplete documentation can occur if workflow is not standardized especially in cases with interdisciplinary involvement. Documentation for patients undergoing magnetic resonance imaging (MRI) with anesthesia services was examined and revealed an opportunity for improvement to avoid financial losses. A preprocedure checklist to improve documentation and standardize workflow was implemented. We compared documentation from preintervention MRI to postintervention MRI with anesthesia services. Documentation that met the reimbursement requirements increased from 5% in the preintervention group to 90% in the postintervention group after the preprocedural checklist implementation. A cost estimate showed a reduction in potential revenue loss from preimplementation to postimplementation groups. The standardization of workflow with the aid of checklists helped meet the documentation requirements for adequate reimbursements and reduced the risk of potential reimbursement losses from payors.
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Anestesia General , Lista de Verificación , Documentación , Imagen por Resonancia Magnética , Humanos , Mecanismo de ReembolsoRESUMEN
Patient safety and the delivery of quality care are major concerns for healthcare in the United States. Special populations (eg, obese patients) need study in order to support patient safety, quantify risks, advance education for healthcare-workers, and establish healthcare policy. Obesity is a complex chronic disease and is considered the second leading cause of preventable death in the United States with approximately 300,000 deaths per year. Obesity is recognized by the Agency for Healthcare Research and Quality (AHRQ) as a comorbid condition. These concerns emphasize the need to focus further research on the obese patient. Through the use of clinical and administrative data, this study examines the incidence of adverse outcomes in the obese surgical population through AHRQ Patient Safety Indicators (PSI) and allows for the engagement PSIs as measures to guide and improve performance. In this study, the surgical population was overwhelmingly positive for obesity. Body mass index (BMI) was also a significant positive predictor for 2 of 3 postoperative outcomes. This finding suggests that as BMI reaches the classification of obesity, the risk of these adverse outcomes increases. It further suggests there exists a threshold BMI that requires anticipation of alterations to systems and processes to revise outcomes.
Asunto(s)
Obesidad/epidemiología , Seguridad del Paciente , Complicaciones Posoperatorias/epidemiología , Procedimientos Quirúrgicos Operativos/efectos adversos , Índice de Masa Corporal , Humanos , Indicadores de Calidad de la Atención de Salud , Estados Unidos , United States Agency for Healthcare Research and QualityRESUMEN
This research addresses an important methodological issue on patient safety and obesity for the purposes of examining clinical and administrative data for the reliability of using International Classification of Diseases (ICD) diagnoses codes alone to reliably identify obesity as a comorbidity and risk factor in care and management. The findings of this research confirm ICD codes for the obese surgical populations were underutilized. Despite more than 70% of patients classified as overweight or obese, ICD-9 codes for obesity were assigned in less than 10% of the overall sample. Patients in the extreme category of obesity (body mass index [BMI] >40 kg/m) were more likely to have a corresponding ICD-9 code compared with patients in the BMI range of 25 to 40 kg/m. International Classification of Diseases, Ninth Revision coding for obesity was underutilized in patients with a BMI of greater than 25 kg/m. The associated health risks, costs, and potential adverse events associated with obesity make it imperative to continue to study the barriers to coding.
Asunto(s)
Registros Electrónicos de Salud/estadística & datos numéricos , Clasificación Internacional de Enfermedades/estadística & datos numéricos , Obesidad/clasificación , Bases de Datos Factuales , Humanos , Obesidad/cirugía , Estudios Retrospectivos , Factores de RiesgoRESUMEN
OBJECTIVE: Diagnostic errors lead to preventable hospital morbidity and mortality. ICU patients may be at particularly high risk for misdiagnosis. Little is known about misdiagnosis in pediatrics, including PICU and neonatal ICU. We sought to assess diagnostic errors in PICU and neonatal ICU settings by systematic review. DATA SOURCES: We searched PubMed, Embase, CINAHL, and Cochrane. STUDY SELECTION: We identified observational studies reporting autopsy-confirmed diagnostic errors in PICU or neonatal ICU using standard Goldman criteria. DATA EXTRACTION: We abstracted patient characteristics, diagnostic error description, rates and error classes using standard Goldman criteria for autopsy misdiagnoses and calculated descriptive statistics. DATA SYNTHESIS: We screened 329 citations, examined 79 full-text articles, and included 13 studies (seven PICU; six neonatal ICU). The PICU studies examined a total of 1,063 deaths and 498 autopsies. Neonatal ICU studies examined a total of 2,124 neonatal deaths and 1,259 autopsies. Major diagnostic errors were found in 19.6% of autopsied PICU and neonatal ICU deaths (class I, 4.5%; class II, 15.1%). Class I (potentially lethal) misdiagnoses in the PICU (43% infections, 37% vascular) and neonatal ICU (62% infections, 21% congenital/metabolic) differed slightly. Although missed infections were most common in both settings, missed vascular events were more common in the PICU and missed congenital conditions in the neonatal ICU. CONCLUSION: Diagnostic errors in PICU/neonatal ICU populations are most commonly due to infection. Further research is needed to better quantify pediatric intensive care-related misdiagnosis and to define potential strategies to reduce their frequency or mitigate misdiagnosis-related harm.