Segmental intestinal necrosis in a young patient.

Segmental ischemic colitis is an uncommon disease in young patients, being usually associated to drug abuse, infectious or autoimmune diseases. We present a case that, in spite of a complete diagnostic study, had repeatedly two attacks of intestinal necrosis during his admission.

Spontaneous rupture of a liver hemangioma. A case report.

Spontaneous rupture of a liver hemangioma is a very uncommon disease, but extremely seriousness because it is associated to a 75% of mortality caused by hipovolemic shock. A case of an spontaneous rupture of liver hemangioma, which was previously unknow, is presented.

Protective ileostomy: complications and mortality associated with its closure.

INTRODUCTION: diverting loop ileostomies are widely used in colorectal surgery to protect low rectal anastomoses. However, they may have various complications, among which are those associated with the subsequent stoma closure. The present study analyses our experience in a series of patients undergoing closure of loop ileostomies. METHOD: retrospective study of all the patients undergoing ileostomy closure at our hospital between 2006-2010. There were 89 patients: 56 males (63%) and 33 females (37%) with a mean age of 55 (38-71) years. The most common indication for ileostomy was protection of a low rectal anastomosis, 81 patients (91%). The waiting time until stoma closure, type and frequency of the complications, length of hospital stay and mortality rate are analysed. RESULTS: waiting time before surgery was 8 (1-25) months. Forty-one patients (45,9%) developed some type of complication, three were reoperated (3.37%) and one patient died (1.12%). The most important complications were intestinal obstruction (32.6%), diarrhoea(6%), surgical wound infection (6%), enterocutaneous fistula (4.5%), rectorrhagia (3.4%) and anastomotic leak (1.12%). The mean length of patient stay was 7.54 (2-23) days. CONCLUSIONS: protective ostomies in low rectal anastomoses have proved to be the only preventive measure for reducing the morbidity and mortality rates for anastomotic leakage. However, creation means subsequent closure, which must not be considered a minor procedure but an operation with possibly significant complications, including death, as has been shown in publications on the subject and in our own series.

[One-step nucleic acid amplification (OSNA) assay for sentinel lymph node metastases as an alternative to conventional postoperative histology in breast cancer: A cost-benefit analysis]. / El análisis molecular intraoperatorio (one-step nucleic acid amplification) del ganglio centinela como alternativa al estudio histopatológico diferido en el cáncer de mama: análisis coste-beneficio.

INTRODUCTION: Intraoperative molecular analysis for sentinel lymph node (SLN) metastases using the OSNA (one-step nucleic acid amplification) method has been already validated in breast cancer. The authors compared the cost of OSNA versus the conventional postoperative histopathologic evaluation in patients with breast cancer. METHODOLOGY: Patients with operable breast cancer and clinically and sonographic negative evaluation of the axilla, and who subsequently were operated on between the 15th of October 2008 and the 15th of December 2009 were included in this retrospective cost-benefit analysis. The SLN was assessed by conventional postoperative histological evaluation in Group 1 (45 patients), and by OSNA in Group 2 (35 patients). The following variables were analysed: age, tumour size, histological type, number of SLNs, biopsy result, duration of surgery, days in hospital, postoperative complications, positive lymph nodes in the case of axillary lymphadectomy, cost per patient, hospitalisation cost, and cost per operation. RESULTS: The duration of surgery of the first operation in Group 1 was significantly shorter, but the total time was also higher in this group. The mean hospital stay was longer in Group 1 (P<.001). The mean cost of the hospital stay was higher in Group 1 compared to Group 2 (P<.001), with a mean difference of 199.69 €. The mean cost of the surgery was higher in Group 1 (P<.001), with a mean difference of 157.49 €. The mean cost per SLN analysis was significantly higher in Group 1, with a mean difference of 162.5 €. The cost per patient was significantly higher in Group 1 (P<.005). A mean saving of 439.67 € per patient was achieved by using the OSNA method. CONCLUSION: Intraoperative molecular analysis for SLN metastases using the OSNA method reduces the number of admission days, duration of surgery, and achieves a saving of 439.67 € per patient.

Adult intussusception - 14 case reports and their outcomes.

AIMS: To analyze diagnostic and therapeutic options depending on the clinical symptoms, location, and lesions associated with intussusception, together with their follow-up and complications. PATIENTS AND METHODS: Patients admitted to the Morales Meseguer General University Hospital (Murcia) between January 1995 and January 2009, and diagnosed with intestinal invagination. Data related to demographic and clinical features, complementary explorations, presumptive diagnosis, treatment, follow-up, and complications were collected. RESULTS: There were 14 patients (7 males and 7 females; mean age: 41.9 years-range: 17-77) who presented with abdominal pain. The most reliable diagnostic technique was computed tomography (8 diagnoses from 10 CT scans). A preoperative diagnosis was established in 12 cases. Invaginations were ileocolic in 8 cases (the most common), enteric in 5, and colocolic in 2 (coexistence of 2 lesions in one patient). The etiology of these intussusceptions was idiopathic or secondary to a lesion acting as the lead point for invagination. Depending on the nature of this lead point, the cause of the enteric intussusceptions was benign in 3 cases and malignant in 2. Ileocolic invaginations were divided equally (4 benign and 4 malignant), and colocolic lesions were benign (2 cases). Conservative treatment was implemented for 4 patients and surgery for 10 (7 in emergency). Five right hemicolectomies, 3 small-bowel resections, 2 left hemicolectomies, and 1 ileocecal resection were performed. Surgical complications: 3 minor and 1 major (with malignant etiology and subsequent death). The lesion disappeared after 3 days to 6 weeks in patients with conservative management. Mean follow-up was 28.25 months (range: 5-72 months). CONCLUSIONS: A suitable imaging technique, preferably CT, is important for the diagnosis of intussusception. Surgery is usually necessary but we favor conservative treatment in selected cases.

Necrosis intestinal segmentaria en paciente joven / Segmental intestinal necrosis in a young patient

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Gastrointestinal bleeding and bowel obstruction as a presentation of Bouveret syndrome.

BACKGROUND: Bouveret syndrome is a rare entity consisting of duodenal obstruction due to a gallstone from the gallbladder. CLINICAL CASES: We present two patients with very different ages and comorbidities whose conditions were resolved in two different ways: a 41-year-old female with right upper quadrant pain and vomiting who underwent surgical correction of obstruction and fistula, and an 81-year-old female with a high bowel obstruction, only treating the obstruction without intervention of the fistula. CONCLUSIONS: It is important to include high gastrointestinal obstruction in the differential diagnosis. Diagnosis can be made either by radiological or endoscopic techniques and therapeutic options are diverse, ranging from endoscopic removal to surgery (with the resolution of obstruction and fistula in the same surgical procedure). This condition usually affects elderly patients with high comorbidities and high surgical risk; therefore, most authors recommend using the most conservative possible treatment.

Necrosis séptica de miembro inferior secundaria a picadura de araña reclusa parda / Septic limb necrosis, secondary to a brown recluse spider bite

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Rotura espontánea de hemangioma hepático no conocido / Spontaneous rupture of a liver hemangioma. A case report

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Vólvulo gástrico agudo. A propósito de un caso / Acute gastric volvulus: A case report

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Síndrome de Horner traumático sin lesión vascular / Traumatic Horner syndrome without vascular injury

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Variables relacionadas con la diseminación metastásica axilar en el cáncer de mama con ganglio centinela positivo. Evaluación de modelos predictivos / Factors related to metastatic axillary disease in breast cancer patients with a positive sentinel lymph node. Evaluation of predictive models

Objetivos. Evaluar las variables relacionadas con la diseminación metastásica axilar e intentar validar los diferentes modelos predictivos creados hasta la fecha. Pacientes y método. Realizamos un estudio retrospectivo a lo largo de 10 años. Fueron incluidas todas las pacientes intervenidas de cáncer de mama en nuestro hospital con ganglio centinela positivo. Se recogieron 27 variables clínico/histológicas del tumor y se realizó un análisis uni/multivariante para valorar la relación con la presencia de metástasis en ganglios axilares no centinelas. Se aplicaron los modelos predictivos a nuestra población: MSKCC, Stanford, Tenon, Meretoja unicéntrico y Meretoja multicéntrico y se calculó para cada uno de ellos el área bajo la curva de característica operativa de receptor (ROC). Resultados. Las variables significativas con la diseminación metastásica axilar fueron el IMC, la macrometástasis en el ganglio centinela, la unifocalidad y la extensión extranodal. Ningún modelo predictivo pudo ser validado, pues todos presentan una capacidad discriminativa diagnóstica baja, con áreas bajo la curva menores de 0,7. Conclusiones. Los modelos predictivos de diseminación metastásica axilar en caso de ganglio centinela positivo por sí solos no permiten discriminar aquellas pacientes con afectación metastásica axilar en el ganglio no centinela (AU)

Objectives. To evaluate factors related to metastatic axillary disease and to validate and update the predictive models created to date for metastatic axillary disease. Patients and method. In this retrospective study, we included all patients with a positive sentinel lymph node biopsy who underwent breast cancer surgery in our hospital in the last 10 years. We obtained 27 clinical/histopathological variables for each patient and univariate and multivariate statistical analyses were performed to evaluate the relationship between these variables and the presence of metastases in non-sentinel axillary nodes. We applied the main published predictive models (MSKCC, Stanford, Tenon, Meretoja single-center and multicenter models) to our population. The area under the receiver operating characteristic curve was calculated for each of the models. Results. The variables significantly related to metastatic axillary disease were body mass index, macrometastases in the sentinel lymph node, single-focus, and extranodal spread. None of the predictive models was validated because all of them had low diagnostic discrimination, with areas below the curve lower than 0.7. Conclusions. Predictive models for metastatic axillary disease in patients with a positive sentinel lymph node have low diagnostic accuracy in identifying low risk patients (AU)