Predicting nipple-areolar involvement using preoperative breast MRI and primary tumor characteristics.

BACKGROUND: Preoperative assessment of the nipple-areolar complex (NAC) is invaluable when considering nipple-sparing mastectomy. Our hypothesis is that breast magnetic resonance imaging (MRI) may predict involvement of the NAC with tumor. METHODS: Clinical, histopathologic, and imaging data were compiled for patients who underwent preoperative breast MRI followed by mastectomy or nipple-sparing mastectomy for malignancy between 2006 and 2009. Blinded rereview of all MRI studies was performed by a breast MRI imager and compared to initial MRI findings. Multivariate analysis identified variables predicting NAC involvement with tumor. RESULTS: Of 77 breasts, 18 (23 %) had tumor involving or within 1 cm of the NAC. The sensitivity of detecting histopathologically confirmed NAC involvement was 61 % with history and/or physical examination, and 56 % with MRI. Univariate analysis identified the following variables as significant for NAC involvement: large tumors near the nipple on preoperative MRI, node-positive disease, invasive lobular carcinoma, advanced histopathologic T stage, and neoadjuvant chemotherapy. On multivariate analysis, only tumor size >2 cm and distance from tumor edge to the NAC <2 cm on MRI maintained significance. Pearson correlation coefficient for MRI size compared to histopathologic size was 0.53 (P < 0.0001). CONCLUSIONS: MRI is not superior to thorough clinical evaluation for predicting tumor in or near the NAC. However, MRI-measured tumor size and distance from the NAC are correlated with increased risk of NAC involvement. The combination of preoperative history and physical examination, tumor characteristics, and breast MRI can aid the surgeon in predicting a tumor-involved nipple more than any single modality alone.

Local and regional control in breast cancer: role of sentinel node biopsy.

The development and acceptance of the SLND has profoundly affected the management of breast cancer. SLND has supplanted ALND as a highly accurate and less-morbid axillary staging procedure in patients with clinically node-negative early-stage breast cancer. SLND alone is associated with less than 1% isolated axillary recurrence in patients with node-negative disease and provides excellent regional nodal control. Historically, ALND has been the recommended treatment for patients with SLN metastases. ALND was thought to offer prognostic information, prevent axillary local recurrence, and possibly render a small survival benefit. However, resection of nonsentinel nodes with metastases may not affect survival, and not all axillary metastases progress to become clinically evident. Furthermore, with increased understanding of tumor biology, nodal status and number of involved lymph nodes are no longer the only determinants of systemic therapy. As improved breast cancer screening allows identification of early-stage disease localized to the breast, and because treatment plans are more often made on the basis of tumor biology, the role of completion ALND may be less critical. The low LRR rates seen in the ACOSOG Z0011 trial, several other randomized trials, and retrospective reviews suggest that SLND alone may provide adequate locoregional control and provide adequate information to guide adjuvant systemic therapy in selected women with clinically node-negative early-stage breast cancer.

Selective approach to use of upper gastroesophageal imaging study after laparoscopic Roux-en-Y gastric bypass.

BACKGROUND: Many institutions routinely perform upper gastroesophageal imaging (UGI) studies on their laparoscopic Roux-en-Y gastric bypass (LRYGB) patients after surgery. We had routinely studied our patients with UGI on postoperative day 1 to rule out an anastomotic leak or obstruction, until recently when we abandoned this practice. As previously reported, we found that routine UGI did not contribute significantly to patient care. The purpose of this study was to determine whether patient outcomes were affected by this change in protocol. METHODS: From March 2004 to September 2005, 508 LRYGB cases were performed at our institution. Linear cutting staplers were used to create both the gastrojejunostomy and the jejunojejunostomy. In each case, the Roux limb was brought up in an antecolic, antegastric configuration. Before changing our protocol, 194 LRYGB cases were performed, and each patient underwent a routine UGI study (group 1). After abandoning this practice, 314 LRYGB cases were performed (group 2), and an UGI study was obtained only if clinical indicators (e.g., tachypnea, tachycardia, nausea, vomiting, low urine output, and/or abdominal pain) were present. The patient demographics, including gender, age, body mass index, length of hospital stay, and complications were recorded in our bariatric database and reviewed retrospectively. RESULTS: A postoperative UGI study was obtained in 204 patients--in 194 patients routinely (group 1) and in 10 patients because of clinical indications (group 2). No obstructions or leaks were found in any of these 204 patients. In group 2, 304 patients were discharged without an UGI series and did well without any leak or obstruction, except for 1 patient who returned 3 months postoperatively with a stricture at his jejunojejunostomy. No statistically significant differences were found between the 2 groups. CONCLUSION: The results of our study have shown that routine UGI studies after LRYGB do not contribute significantly to postoperative patient care at our institution. We now perform them selectively according to clinical indications, without this change adversely affecting our clinical outcomes.

Improved outcomes using a systematic and evidence-based approach to the laparoscopic Roux-en-Y gastric bypass in a single academic institution.

No standardized approach exists for laparoscopic Roux-en-Y gastric bypass (LRYGB). At a newly instituted bariatric surgery program, four experienced laparoscopic surgeons used the systematic and evidence-based approach consisting of multidisciplinary preoperative evaluation, screening, and education; standardized operative technique; inpatient clinical pathway; and close postoperative follow-up. The outcomes were subsequently analyzed to determine if this approach improved the morbidity and mortality. From January 2003 to June 2006, 835 consecutive LRYGBs were performed. The patient population was 85 per cent women with a mean body mass index (BMI) of 50.4 kg/m2 (range 33-96 kg/m2). The mean age was 44 (range 15-67). Sixty-two per cent of the patients had previous abdominal or pelvic operations. The conversion rate to open surgery was 0.2 per cent. The average length of hospital stay was 2.6 days (range 2-13 days). There were no anastomotic leaks or deaths. The 30-day readmission and re-operation rates were 3.2 per cent and 1.8 per cent, respectively. The incidence of anastomotic stricture, marginal ulcer, bleeding, pulmonary embolism, and internal hernia was 0.8 per cent, 3.5 per cent, 4.2 per cent, 0.1 per cent, and 0.4 per cent, respectively. A systematic and evidence-based approach to the LRYGB by experienced laparoscopic surgeons resulted in a lower incidence of complications when compared with the published results from other comparable institutions.

A pneumatic haptic feedback actuator array for robotic surgery or simulation.

Robot-assisted minimally invasive surgery (MIS) offers improved range of motion over standard laparoscopic techniques, but is characterized by a total loss of haptic feedback, requiring surgeons to rely solely on visual cues. Pneumatic tactile displays have many advantages, including low mass, low cost, compact size, and adaptability. A pneumatic haptic feedback actuator array has been developed that is suitable for mounting unto surgical robotic tools. The balloon actuators consist of spin-coated thin-film silicone membranes and molded substrates with cylindrical channels. Human perceptual tests were conducted on balloon diameters ranging from 0.75 to 2.0 mm to determine the optimal size that can be effectively detected. The control system was programmed to sequentially inflate a single balloon to one of the three levels, 100% (full hemispherical deformation), zero, 50% (half deformation), and 0% (no inflation). Blinded subjects (n=5) were asked to determine which of the two inflation levels was higher. Test results suggest that balloon diameters greater than 1.0 mm can deliver high detection accuracy. This indicates that pneumatic balloon-based actuation is a viable solution for generating haptic feedback. In addition to surgical applications, many other fields such as virtual reality-based simulators and neuroprosthetics can benefit from this technology.

Routine postoperative upper gastroesophageal imaging is unnecessary after laparoscopic Roux-en-Y gastric bypass.

Routine early postoperative upper gastroesophageal imaging (UGI) is often used in laparoscopic Roux-en-Y gastric bypass (LRYGB) procedures to confirm anastomotic patency and to exclude leaks. The aim of our study was to assess the usefulness of this practice. From January 2003 to November 2004, 322 LRYGB cases were performed using linear staplers for the gastrojejunostomy and jejuno-jejunostomy anastomoses. As part of our protocol, all patients received a Gastrograffin (Mallinkrodt, Inc., St Louis, Missouri) UGI on postoperative Day 1. The same radiological techniques were used and the same radiological team reviewed all films. Abnormal films were identified. In addition, patient demographics, time to discharge, and complications were collected and analyzed in a prospective database. There were no anastomotic leaks or obstructions. However, 42 of 322 (13%) studies demonstrated delayed gastric emptying. There were no statistically significant differences between patients with normal and delayed UGI studies. Routine UGI studies did not contribute significantly to patient care, and its routine use was subsequently abandoned.