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1.
A phase Ib dose escalation study of oral monotherapy with KX2-391 in elderly patients with acute myeloid leukemia.
Invest New Drugs
; 40(4): 773-781, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35579731
2.
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma.
J Neurooncol
; 140(3): 519-527, 2018 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-30238350
3.
Ligand binding cooperativity: Bioisosteric replacement of CO with SO2 among thrombin inhibitors.
Bioorg Med Chem Lett
; 26(16): 3850-4, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27445170
4.
A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies.
Invest New Drugs
; 31(4): 967-73, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23361621
5.
Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).
J Med Chem
; 61(11): 4704-4719, 2018 06 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29617135
6.
Binding cooperativity between a ligand carbonyl group and a hydrophobic side chain can be enhanced by additional H-bonds in a distance dependent manner: A case study with thrombin inhibitors.
Eur J Med Chem
; 96: 405-24, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25912673
7.
A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer.
Cancer Chemother Pharmacol
; 71(4): 883-92, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23314737
8.
Targeting SRC and tubulin in mucinous ovarian carcinoma.
Clin Cancer Res
; 19(23): 6532-43, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24100628
9.
Thermodynamic inhibition profile of a cyclopentyl and a cyclohexyl derivative towards thrombin: the same but for different reasons.
Angew Chem Int Ed Engl
; 46(44): 8511-4, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17902081
10.
Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities.
Eur J Med Chem
; 46(10): 4853-8, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21852023
11.
Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors.
J Med Chem
; 53(5): 2126-35, 2010 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20148533
12.
Synthesis of a Vicinal Tricarbonyl Amide Derivative of L-Phenylalanine.
J Org Chem
; 61(5): 1872-1874, 1996 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-11667067
13.
Privileged scaffolds for blocking protein-protein interactions: 1,4-disubstituted naphthalene antagonists of transcription factor complex HOX-PBX/DNA.
Bioorg Med Chem Lett
; 14(15): 3875-9, 2004 Aug 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15225688
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