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1.
Int J Biometeorol ; 68(7): 1315-1326, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38705900

RESUMEN

Winter cold wave adaptation strategies in hot climates due to climate change didn't receive the deserved attention from previous studies. Therefore, this study comprehensively investigates the impact of various windbreak parameters on mitigating winter cold stress in hot steppe-arid climate. A microclimate model for a residential campus was built and validated through on-site measurement on a typical winter day to assess thirty-two scenarios for tree characteristics and spatial configuration windbreak parameters based on PET, wind speed, and Air Temperature (AT). Moreover, four configurations, that had best results on mitigating cold stress in winter, were tested during typical summer conditions to couple the assessment of cold and hot seasons. Additionally, environmental analysis for all scenarios was conducted. The results revealed that the most effective parameters for mitigating cold stress are tree distribution, Leaf Area Density (LAD), row number, spacing, and shape. Double rows of high LAD and medium height trees with small spacing yielded the best cold stress mitigation effect. Furthermore, the windbreak reduced the cold stress in the morning and night by 19.31% and 18.06%, respectively. It reduced AT and wind speed at night by 0.79 °C and 2.56 m/s, respectively. During summer, very hot PET area was reduced by 21.79% and 19.5% at 12:00 and 15:00, respectively.


Asunto(s)
Cambio Climático , Microclima , Modelos Teóricos , Estaciones del Año , Árboles , Viento , Frío
2.
N Engl J Med ; 382(3): 256-265, 2020 01 16.
Artículo en Inglés | MEDLINE | ID: mdl-31940699

RESUMEN

Deficiency of ubiquitin-specific peptidase 18 (USP18) is a severe type I interferonopathy. USP18 down-regulates type I interferon signaling by blocking the access of Janus-associated kinase 1 (JAK1) to the type I interferon receptor. The absence of USP18 results in unmitigated interferon-mediated inflammation and is lethal during the perinatal period. We describe a neonate who presented with hydrocephalus, necrotizing cellulitis, systemic inflammation, and respiratory failure. Exome sequencing identified a homozygous mutation at an essential splice site on USP18. The encoded protein was expressed but devoid of negative regulatory ability. Treatment with ruxolitinib was followed by a prompt and sustained recovery. (Funded by King Saud University and others.).


Asunto(s)
Enfermedades Autoinflamatorias Hereditarias/tratamiento farmacológico , Interferones/metabolismo , Interleucinas/metabolismo , Janus Quinasa 1/antagonistas & inhibidores , Inhibidores de las Cinasas Janus/uso terapéutico , Mutación con Pérdida de Función , Pirazoles/uso terapéutico , Ubiquitina Tiolesterasa/deficiencia , Homocigoto , Humanos , Hidrocefalia/genética , Recién Nacido , Masculino , Nitrilos , Pirimidinas , Receptores de Interferón/metabolismo , Inducción de Remisión , Choque Séptico/genética , Transducción de Señal/genética , Ubiquitina Tiolesterasa/genética , Secuenciación del Exoma
3.
J Anim Physiol Anim Nutr (Berl) ; 107(1): 214-221, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-35098590

RESUMEN

This study aimed to determine the impact of supplementation of turmeric powder on laying performance, egg quality, nutrient digestibility and some blood metabolites in laying hens. A total of one hundred and twenty Bovans Brown laying hens (55 weeks old) were assigned to one of four treatment diets (n = 30) for 12 weeks including turmeric powder at 0, 2.5, 5 or 7.5 g/kg respectively. The results revealed that egg production, egg weight and egg mass were significantly increased (p < 0.05), and the feed conversion ratio was significantly improved (p < 0.012) with increasing levels of turmeric in the laying hen diet. Egg thickness and Haugh unit were linearly increased (p < 0.01) with increasing supplementation levels. Moreover, compared with the control diet, the levels of turmeric powder supplementation significantly improved nutrient digestibility (p < 0.001). Moreover, the serum metabolic profile revealed that serum total cholesterol, aspartate aminotransferase, creatinine and urea concentrations were linearly decreased with increasing turmeric powder supplementation to hen diets. In conclusion, the inclusion of turmeric powder at 2.5, 5 or 7.5 g/kg diet improved egg production, nutrient digestibility, egg quality and serum metabolic profile and may be used as a feed additive in laying hens' nutrition. However, results indicate that the best improvement was observed when 5 g/kg were supplemented.


Asunto(s)
Pollos , Curcuma , Animales , Femenino , Pollos/fisiología , Polvos , Dieta/veterinaria , Suplementos Dietéticos , Alimentación Animal/análisis , Fenómenos Fisiológicos Nutricionales de los Animales
4.
Appl Microbiol Biotechnol ; 106(17): 5539-5550, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-35906995

RESUMEN

Rhizorhabdus (previously Sphingomonas) wittichii RW1 uses a diverse array of aromatic organic compounds as energy and carbon sources, including some extremely recalcitrant compounds such as dibenzo-p-dioxin and dibenzofuran. Extradiol dioxygenases play a key role in the metabolism of dibenzofuran (DBF), dibenzo-p-dioxin (DBD), PCBs, and various other aromatic compounds. In this study, a detailed kinetic analysis of four extradiol dioxygenases identified in R. wittichii RW1 (DbfB, Edo2, Edo3, and Edo4) showed all of them to be typical 2,3dihydroxybiphenyl (DHB) dioxygenases with DHB as preferred substrate (kcat/Km values of 0.13-188 (µM -1 s-1)) and only slightly lower activity against trihydroxybiphenyl (THB) whereas monocyclic substrates were, to different extents, poor substrates due to high km values. All extradiol dioxygenases analyzed were subject to mechanism-based inactivation by 2,2`,3-trihydroxybiphenylether (THBE) the intermediate of DBD degradation. However, Edo4 was superior as reflected by the relatively high partition ratio and the comparably low efficiency of inactivation. Significant differences were observed with respect to their inactivation by 3-chlorocatechol. The absence of any significant mechanism-based inactivation makes Edo3 a perfect candidate for being recruited for chlorobiphenyl degradation where inactivation of extradiol dioxygenases by this intermediate creates significant metabolic problems. KEY POINTS: • Characterization of additional extradiol dioxygenases encoded by RW1 • Identification of differences in 2,2`,3-trihydroxybiphenylether transformation • Identification of differences in inhibition by 3-chlorocatechol.


Asunto(s)
Dioxigenasas , Sphingomonas , Dibenzofuranos , Cinética , Oxigenasas
5.
Curr Microbiol ; 79(10): 294, 2022 Aug 22.
Artículo en Inglés | MEDLINE | ID: mdl-35989347

RESUMEN

Haloalkophilic bacteria have a potential advantage as a bioremediation organism of high oil-polluted and industrial wastewater. In the current study, Haloalkaliphilic isolates were obtained from Hamralake, Wadi EL-Natrun, Egypt. The phenotype script, biochemical characters, and sequence analysis of bacterial-16S rRNA were used to identify the bacterial isolates; Halomonas HA1 and Marinobacter HA2. These strains required high concentrations of NaCl to ensure bacterial growth, especially Halomonas HA1 strain. Notably, both isolates can degrade phenol at optimal pH values, between 8 and 9, with the ability to grow in pH levels up to 11, like what was seen in the Halomonas HA1 strain. Moreover, both isolates represent two different mechanistic pathways for phenol degradation. Halomonas HA1 exploits the 1,2 phenol meta-cleavage pathway, while Marinobacter HA2 uses the 2,3 ortho-cleavage pathway as indicated by universal primers for 1,2 and 2,3 CTD genes. Interestingly, Marinobacter HA2 isolate eliminated the added phenol within an incubation period of 72 h, while the Halomonas HA1 isolate invested 96 h in degrading 84% of the same amount of phenol. Phylogenetic analysis of these 1,2 CTD (catechol dioxygenase) sequences clearly showed an evolutionary relationship between 1,2 dioxygenases of both Halomonadaceae and Pseudomonadaceae. In comparison, 2,3 CTD of Marinobacter HA2 shared the main domains of the closely related species. Furthermore, semi-quantitative RT-PCR analysis proved the constitutive expression pattern of both dioxygenase genes. These findings provide new isolates of Halomonas sp. and Marinobacter sp. that can degrade phenol at high salt and pH conditions via two independent mechanisms.


Asunto(s)
Dioxigenasas , Halomonas , Marinobacter , Dioxigenasas/genética , Dioxigenasas/metabolismo , Marinobacter/genética , Fenol/metabolismo , Fenoles/metabolismo , Filogenia , ARN Ribosómico 16S/genética , ARN Ribosómico 16S/metabolismo
6.
Foodborne Pathog Dis ; 19(3): 192-198, 2022 03.
Artículo en Inglés | MEDLINE | ID: mdl-34847725

RESUMEN

The aim of this study was to determine the occurrence, phenotypic and molecular characteristics of vancomycin-resistant enterococci (VRE), isolated from retail raw cow's milk. One hundred milk samples collected from retail shops in Egypt were examined for the occurrence of VRE by using kanamycin aesculin azide agar supplemented with 4 µg/mL vancomycin. PCR was conducted to determine enterococcal species and to screen the isolated strains for the presence of antibiotic resistance and virulence genes. All isolated strains were characterized by antimicrobial susceptibility testing for 12 antibiotics. From 24 samples (24%), we recovered 22 isolates (91.6%) classified as VRE (minimum inhibitory concentration ≥32) and 2 isolates (8.3%) classified as intermediate resistant to vancomycin (≤16). Enterococcus faecium (29.1%), Enterococcus faecalis (12.5%), Enterococcus casseliflavus (16.6%), and Enterococcus gallinarum (4.1%) were identified by using multiplex PCR. The genus Enterococcus was resistant to clindamycin (100%), linezolid (91.6%), teicoplanin (91.6%), erythromycin (87.5%), and tetracycline (29.1%). Co-resistance to vancomycin, teicoplanin, and linezolid was detected in 83.3% of isolates. Antibiotic resistance genes vanB, tet(M), tet(L), and erm(B) were identified in 29.1%, 16.6%, 8.3%, and 4.1% of isolates, respectively. Virulence genes gelE and esp were detected in 16.6% and 12.5% of isolates, respectively. In conclusion, the high occurrence of co-resistance to vancomycin, teicoplanin, and linezolid reported in this study is alarming. The high frequency of linezolid resistance prompts increased the attention of researchers to routinely perform linezolid susceptibility in food isolates. This study declares potential food safety risks from consumption and improper handling of raw milk regarding clinically important bacteria and promotes necessary legislation for forbidding the selling and consumption of retail raw milk.


Asunto(s)
Enterococcus faecium , Infecciones por Bacterias Grampositivas , Enterococos Resistentes a la Vancomicina , Animales , Antibacterianos/farmacología , Bovinos , Egipto , Femenino , Infecciones por Bacterias Grampositivas/microbiología , Linezolid , Pruebas de Sensibilidad Microbiana , Leche , Reacción en Cadena de la Polimerasa Multiplex , Teicoplanina , Vancomicina/farmacología , Resistencia a la Vancomicina , Enterococos Resistentes a la Vancomicina/genética
7.
Anal Chem ; 92(11): 7947-7954, 2020 06 02.
Artículo en Inglés | MEDLINE | ID: mdl-32383384

RESUMEN

Several reports in the literature deal with the modification of glassy carbon electrode (GCE) surface via electropolymerization of some organic monomers, particularly p-aminobenzenesulfonic acid (p-ABSA) and l-cysteine using intensive oxidative conditions, and attributed the improved electrocatalytic activities toward various analytes to the formation of the electropolymerized layer. What is the real cause for this improvement in electrocatalytic activity? Is it because of the electrochemical activation process of GCE or electropolymerization? Combining a set of surface and electrochemical characterization techniques, we first showed that the electrochemical peaks previously assigned in many reports to electropolymerization processes at the surface of GCE correspond to electrochemical activation of the GCE surface. We further demonstrated that the anodization of GCE at high voltage causes activation of its surface and the formation of surface functional groups (SFGs). In fact, those SFGs are found to be the main reason for the enhancement in electrocatalytic activity of the activated GCE (AGCE). The surface features of the modified electrodes were characterized by Raman spectroscopy, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). The electrochemical behavior was investigated using cyclic voltammetry (CV). The analytical performance of AGCE toward dopamine (DA) was assessed using differential pulse voltammetry (DPV). As compared to the previously reported dopamine electrochemical sensors assuming such electropolymerization processes, the AGCE showed analytical performance practically similar to that of these sensors. This further confirms that the enhancement in electrocatalytic activity is due to the electrochemical activation of the GCE surface.

8.
Childs Nerv Syst ; 36(1): 213-217, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-31385088

RESUMEN

INTRODUCTION: Juvenile xanthogranuloma (JXG) with the central nervous system (CNS) involvement is a rare disease entity that remains poorly understood, especially when the condition develops following treatment for Langerhans cell histiocytosis (LCH). CASE REPORT: A 21-year-old man who was diagnosed with LCH at age 2, several years following which he developed signs and symptoms of CNS involvement. Magnetic resonance imaging (MRI) of the brain revealed JXG with bilateral choroid plexus involvement. As radiation therapy for the intraventricular masses proved unsuccessful, he underwent two surgical resections. In the following years, he developed another large JXG in the meninges, which was managed conservatively until he required surgery due to symptom progression. Twelve years after the first surgery, the patient is in stable condition with no evidence of recurrence. CONCLUSION: Due to the rarity of JXG in the CNS, optimal treatment strategies and the precise duration of therapy remain to be determined. Future studies should aim to develop an appropriate treatment algorithm for such rare cases.


Asunto(s)
Histiocitosis de Células de Langerhans , Xantogranuloma Juvenil , Adulto , Algoritmos , Encéfalo/diagnóstico por imagen , Encéfalo/cirugía , Humanos , Imagen por Resonancia Magnética , Masculino , Xantogranuloma Juvenil/diagnóstico por imagen , Xantogranuloma Juvenil/cirugía , Adulto Joven
9.
Rev Argent Microbiol ; 51(1): 39-46, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-29605458

RESUMEN

Tributyltin (TBT) is recognized as a major environmental problem at a global scale. Haloalkaliphilic tributyltin (TBT)-degrading bacteria may be a key factor in the remediation of TBT polluted sites. In this work, three haloalkaliphilic bacteria strains were isolated from a TBT-contaminated site in the Mediterranean Sea. After analysis of the 16S rRNA gene sequences the isolates were identified as Sphingobium sp. HS1, Stenotrophomonas chelatiphaga HS2 and Rhizobium borbori HS5. The optimal growth conditions for biodegradation of TBT by the three strains were pH 9 and 7% (w/v) salt concentration. S. chelatiphaga HS2 was the most effective TBT degrader and has the ability to transform most TBT into dibutyltin and monobutyltin (DBT and MBT). A gene was amplified from strain HS2 and identified as TBTB-permease-like, that encodes an ArsB-permease. A reverse transcription polymerase chain reaction analysis in the HS2 strain confirmed that the TBTB-permease-like gene contributes to TBT resistance. The three novel haloalkaliphilic TBT degraders have never been reported previously.


Asunto(s)
Bacterias/metabolismo , Compuestos de Trialquiltina/metabolismo , Contaminantes Químicos del Agua/metabolismo , Biodegradación Ambiental , Egipto , Concentración de Iones de Hidrógeno , Mar Mediterráneo , Tolerancia a la Sal
10.
Neurosciences (Riyadh) ; 24(4): 257-263, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31872803

RESUMEN

OBJECTIVE: To review the experience of 2 tertiary centers in Saudi Arabia with intracranial hypertension (IH) in the pediatric population. METHODS: We retrospectively reviewed and analyzed pediatric patients diagnosed with IH from June 2002 to May 2017 in 2 institutes. RESULTS: We identified 53 patients (30 females and 23 males) with a mean age of 7 years at the time of presentation. Among them, 41 patients were younger than 12 years, and 12 were older. Obese and overweight patients constituted 27.00% (n = 14) of all cases, 8 (66.7%) of whom were older than 12 years. The most common presenting feature was papilledema followed by headache. Vitamin D deficiency, which constituted the most common associated condition, was identified in 12 (22.6%) patients. Acetazolamide was the treatment option in 98.11% of patients, and only 5.7% underwent surgical interventions. The length of follow-up ranged from 6 months to 8 years. CONCLUSION: Intracranial hypertension is rare in children and commonly seen in overweight females older than 12 years similar to adults. Patients younger than 12 years tend to develop secondary IH. More studies are needed to characterize the clinical presentation and guide the management plan.


Asunto(s)
Cefalea/epidemiología , Hipertensión Intracraneal/complicaciones , Obesidad/epidemiología , Papiledema/epidemiología , Deficiencia de Vitamina D/epidemiología , Acetazolamida/uso terapéutico , Niño , Preescolar , Diuréticos/uso terapéutico , Femenino , Hospitales Pediátricos/estadística & datos numéricos , Humanos , Lactante , Hipertensión Intracraneal/tratamiento farmacológico , Hipertensión Intracraneal/epidemiología , Hipertensión Intracraneal/patología , Masculino , Arabia Saudita , Centros de Atención Terciaria/estadística & datos numéricos
12.
Hum Genet ; 134(8): 815-22, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25957586

RESUMEN

Cutis Marmorata Telangiectatica Congenita (CMTC) is a congenital localized or generalized vascular anomaly, usually sporadic in occurrence. It can be associated with other cutaneous or systemic manifestations. About 300 cases have been reported. The molecular etiology remains largely unknown. The main purpose of this study is to delineate the molecular basis for a syndromic CMTC phenotype in a consanguineous Saudi family. Clinical phenotyping including detailed neurological imaging, followed by autozygosity mapping and trio whole exome sequencing (WES) are also studied. We have identified a homozygous truncating mutation in ARL6IP6 as the likely cause of a syndromic form of CMTC associated with major dysmorphism, developmental delay, transient ischemic attacks and cerebral vascular malformations. This gene was previously implicated by genome wide association study (GWAS) as a susceptibility locus to ischemic stroke in young adults. We identify ARL6IP6 as a novel candidate gene for a syndromic form of CMTC. This suggests that ischemic stroke or transient ischemic attacks (TIA) may represent, at least in some cases, the mild end of a phenotypic spectrum that has at its severe end autosomal recessive CMTC. This finding contributes to a growing appreciation of the continuum of Mendelian and common complex diseases.


Asunto(s)
Isquemia Encefálica/genética , Malformaciones Vasculares del Sistema Nervioso Central/genética , Sitios Genéticos , Predisposición Genética a la Enfermedad , Proteínas de Choque Térmico/genética , Mutación , Enfermedades Cutáneas Vasculares/genética , Accidente Cerebrovascular/genética , Telangiectasia/congénito , Adulto , Preescolar , Femenino , Estudio de Asociación del Genoma Completo , Humanos , Livedo Reticularis , Masculino , Síndrome , Telangiectasia/genética
13.
Am J Med Genet A ; 161A(6): 1207-13, 2013 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-23633300

RESUMEN

Genetic factors represent an important etiologic group in the causation of intellectual disability. We describe a Saudi Arabian family with closley related parents in which four of six children were affected by a congenital cognitive disturbance. The four individuals (aged 18, 16, 13, and 2 years when last examined) had motor and cognitive delay with seizures in early childhood, and three of the four (sparing only the youngest child) had progressive, severe cognitive decline with spasticity. Two affected children had ocular malformations, and the three older children had progressive visual loss. The youngest had normal globes with good functional vision when last examined but exhibited the oculodigital sign, which may signify a subclinical visual deficit. A potentially deleterious nucleotide change (c.1A>G; p.Met1Val) in the C12orf57 gene was homozygous in all affected individuals, heterozygous in the parents, and absent in an unaffected sibling and >350 normal individuals. This gene has no known function. This family manifests a autosomal recessive syndrome with some phenotypic variability that includes abnormal development of brain and eyes, delayed cognitive and motor milestones, seizures, and a severe cognitive and visual decline that is associated with a homozygous variant in a newly identified gene.


Asunto(s)
Trastornos de los Cromosomas/genética , Trastornos del Conocimiento/genética , Trastornos Heredodegenerativos del Sistema Nervioso/genética , Trastornos de la Visión/genética , Adolescente , Sustitución de Aminoácidos , Preescolar , Trastornos de los Cromosomas/diagnóstico por imagen , Mapeo Cromosómico , Trastornos del Conocimiento/diagnóstico por imagen , Femenino , Estudios de Seguimiento , Genotipo , Trastornos Heredodegenerativos del Sistema Nervioso/diagnóstico por imagen , Secuenciación de Nucleótidos de Alto Rendimiento , Homocigoto , Humanos , Discapacidad Intelectual/genética , Masculino , Linaje , Mutación Puntual , Radiografía , Arabia Saudita , Análisis de Secuencia de ADN , Hermanos
14.
Ann Plast Surg ; 71(5): 503-9, 2013 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-24126338

RESUMEN

Sixteen patients (11 men and 5 women), who formed the basis of the study, underwent surgery in the Hand and Reconstruction Microsurgical Unit, Orthopedic Department, Sohag Faculty of Medicine, from January 2001 to January 2009.The right side was involved in 7 cases and the left side in 9 cases. Average age was 35.2 years. The causes of bone defects were infected nonunion of both bone forearms in 5 cases, infected nonunion of the middle part of radius in 4 cases, posttraumatic bone loss of distal radius in 4 cases, and tumor of shaft humerus in 3 cases (aneurysmal bone cyst in 1 and osteosarcoma in 2 patients).The principle of treatment was debridement and excision of either infected unhealthy bone or tumor tissues with wide safety margin.The average bone defect was 8 cm (range, 6-14 cm). The defect was bridged by osteoseptocutaneous vascularized fibular bone graft. The donor bone was the right fibula in 7 cases and the left fibula in 10 cases. Two grafts were used in 1 patient because of soft tissue injuries, which included the peroneal vessels during osteotomy. The vascularized fibula was fixed by small dynamic compression plate. The operative time ranged between 7 and 11 hours. Blood transfusion was indicated in all the cases and its average transfusion was 1000 mL. The average follow-up was 84 months. Bone union was ultimately obtained in 15 patients except 1 who had failure of the graft. Arthrodesis of the distal ulna with the wrist joint was done during the follow-up. Arthrodesis of the wrist joint was also performed for 1 patient who had loss of carpal bones, distal radius, and wrist and finger extensors. The average time for union was 3.5 months. The hand function was normal in all cases. Stress fracture and fibular donor-site morbidity did not occur in this series. Neither shoulders nor elbows were affected postoperatively. There was no recurrence for either infection or tumor.


Asunto(s)
Enfermedades Óseas/cirugía , Trasplante Óseo/métodos , Peroné/trasplante , Traumatismos del Antebrazo/cirugía , Fracturas no Consolidadas/cirugía , Alotrasplante Compuesto Vascularizado/métodos , Adulto , Infecciones Bacterianas/etiología , Infecciones Bacterianas/prevención & control , Femenino , Peroné/irrigación sanguínea , Estudios de Seguimiento , Fracturas no Consolidadas/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Oseointegración , Osteítis/etiología , Osteítis/prevención & control , Rango del Movimiento Articular , Procedimientos de Cirugía Plástica/métodos , Colgajos Quirúrgicos/irrigación sanguínea , Resultado del Tratamiento , Adulto Joven
15.
Ann Plast Surg ; 71(5): 510-8, 2013 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-24126339

RESUMEN

PURPOSE: Children who had internal rotation contracture deformities of the shoulder secondary to obstetric brachial plexus palsy were studied. The outcomes of anterior shoulder release and tendon transfer in 1-stage procedure were analyzed. METHODS: Anterior shoulder release and tendon transfer in 2 separate incisions as 1 procedure were performed in 76 patients for improvement of shoulder function. Anterior shoulder release was performed through the deltopectoral incision, starting with the coracoid process that extended 5 cm caudally. Osteotomy of the coracoid process subperiosteally with retaining the pectoralis minor attached to the periosteum. Z-plasty of the subscapularis and resuturing of the pectoralis minor short head of biceps and coracobrachialis to their original position were performed in all cases. A separate second incision in the posterior axillary fold was carried out to perform rerouting of the latissimus dorsi and teres major tendons with a mean follow-up of 5.6 years (range, 1-7 years). RESULTS: The average active external rotation with the arm at the side increased from -26 + 15 degrees preoperatively to 67 + 17 degrees postoperatively (average gain, 85 degrees). The average shoulder abduction increased from 46 + 22 degrees preoperatively to 130 + 32 degrees postoperatively (average gain, 75 degrees). Mallet score improved from 12.3 to 22.6. CONCLUSIONS: Anterior shoulder release combined with latissimus dorsi and teres major rerouting significantly improved global shoulder function.


Asunto(s)
Traumatismos del Nacimiento/cirugía , Neuropatías del Plexo Braquial/cirugía , Contractura/cirugía , Liberación de la Cápsula Articular/métodos , Deformidades Adquiridas de la Articulación/cirugía , Articulación del Hombro/cirugía , Transferencia Tendinosa/métodos , Animales , Traumatismos del Nacimiento/complicaciones , Neuropatías del Plexo Braquial/complicaciones , Niño , Preescolar , Contractura/complicaciones , Femenino , Estudios de Seguimiento , Humanos , Lactante , Recién Nacido , Deformidades Adquiridas de la Articulación/etiología , Masculino , Conejos , Rango del Movimiento Articular , Rotación , Articulación del Hombro/fisiopatología , Resultado del Tratamiento
16.
Environ Sci Pollut Res Int ; 30(48): 105840-105855, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37721673

RESUMEN

A new fractional non-Fourier (Cattaneo) photovoltaic (PV) model is presented to enhance the thermal performance of a PV system combined with a heat spreader (HS). The fractional Cattaneo model is shown to be effective in examining transient processes across the entirety of a PV system, in contrast to the conventional Fourier model's inability to predict system performance. Consequently, a comparison is conducted between the classical Fourier model with the fractional Fourier and fractional Cattaneo models for the PV system. The impact of using an aluminum heat spreader, with rectangular and trapezoidal shapes, has been developed under hot and cold climate conditions. The findings show that adding a trapezoidal heat spreader reduced the cell temperature by 20 K in summer and 12 K in winter. The reduction in the PV temperature led to an enhancement in daily average power by approximately 28% and 37% in hot and cold weather, respectively. Moreover, economic, exergoeconomic, and enviroeconomic assessment is introduced. The outcomes revealed that the electrical production costs of the rectangular and trapezoidal HS systems are 0.272 and 0.214 $/kWh, respectively, while about 0.286 $/kWh for the conventional PV panel. Based on the environmental study, the estimated CO2 reduction for PV, PV with rectangular HS, and PV with trapezoidal spreader is 0.5504, 0.7704, and 0.8012 tons, respectively. Finally, real experimental data are used to validate the fractional Cattaneo model. The results demonstrate that there is a great fitting with the measured data, with errors in PV power and exergy efficiency of just 0.628% and 3.84%, respectively, whereas their corresponding values for the classical model are 5.72 and 13.13%.


Asunto(s)
Aluminio , Calor , Temperatura , Clima Frío , Frío
17.
Nanoscale Adv ; 5(20): 5499-5512, 2023 Oct 10.
Artículo en Inglés | MEDLINE | ID: mdl-37822908

RESUMEN

The development of metal-free supercapacitor electrodes with a high energy density is a crucial requirement in the global shift towards sustainable energy sources and industrial pursuit of an optimal supercapacitor. Indeed, from an industrial perspective, time assumes a paramount role in the manufacturing process. A majority of synthesis methods employed for the fabrication of carbon xerogel-based supercapacitor electrodes are characterized by prolonged durations, and result in relatively poor energy and power density. These limitations hinder their practical applications and impede their widespread manufacturing capabilities. In this study, carbon xerogel-based supercapacitor electrodes were made in the shortest time ever reported by making the condition highly acidic with hydrochloric acid (HCl). Furthermore, the investigation of the effect of HCl concentrations (0.1 M, 0.05 M, and 0.01 M) on the morphology and electrochemical behavior of the prepared samples is reported herein. Interestingly, the highest concentration of HCl developed the highest BET surface area, 1032 m2 g-1, which enforced the capacitive behavior to deliver a specific capacitance of 402 F g-1 at 1 A g-1 and a capacitance retention of 80.8% at a current density of 2 A g-1 in an electrolyte containing 0.5 M H2SO4 + 0.5 M Na2SO4. Moreover, an impressive energy density of 45 W h kg-1 at a power density of 18.2 kW kg-1 was achieved. Interestingly, as the HCl concentration increased, the equivalent series resistance decreased to 3.9 W with carbon xerogel 0.1 M HCl (CX0.1). The superior performance of CX0.1 may be attributed to its enlarged BET surface area, pore volume, pore diameter, and smaller particle size. This work provides a facile approach for the large-scale production of metal-free carbon supercapacitor electrodes with improved performance and stability and opens novel horizons to explore the impacts of many types of catalysts during the carbon xerogel preparation.

18.
Sci Rep ; 13(1): 943, 2023 01 18.
Artículo en Inglés | MEDLINE | ID: mdl-36653392

RESUMEN

This study aims to evaluate the effect of hydroponic barley (HB) by substituting control diet with 25% HB with or without enzymes on rabbit performance, nutrient digestibility, and economic efficiency. A total number of 60 growing male HyPlus rabbits (average body weight 669 ± 12 g, 30 days of age) were utilized in the present study. The rabbits were randomly assigned to three groups (n = 20 rabbits per group). The first group served as a control (C). The other two groups were fed the control diet substituted with 25% hydroponic barley HB (group CHB), and the control diet substituted with 25% HB added with 0.5 g/kg enzymes (CHBE). The experiment lasted for 56 days. The results revealed that daily body weight gain improved (P < 0.05) by 18.64% and 23.94%, and feed conversion ratio improved by 3.74% and 17.91% than control, respectively, during 30-86 days of age in CHB and CHBE groups. The economic efficiency was improved (P < 0.05) by 32.17% and 39.60% in CHB and CHBE diets, respectively, compared to control; and nutrient digestibility, and mineral retention of growing rabbits were also improved (P < 0.05) by substituting HB with or without enzymes compared to control diet. Overall, the best rabbit performances were observed in both CHB and CHBE groups. In conclusion, these results suggest that substituting 25% of concentrated control diet by hydroponic barley with or without enzymes have positive effects in a sustainable way on growth performance, nutrient digestibility, and economic efficiency of growing rabbits.


Asunto(s)
Hordeum , Animales , Masculino , Conejos , Alimentación Animal/análisis , Fenómenos Fisiológicos Nutricionales de los Animales , Peso Corporal , Dieta , Digestión , Hidroponía
19.
Animals (Basel) ; 13(12)2023 Jun 09.
Artículo en Inglés | MEDLINE | ID: mdl-37370443

RESUMEN

This study aimed to evaluate the efficacy of dietary Acacia nilotica bark bioactive lipid compounds (ANBBLCs) as novel feed additives on the growth performance, carcass criteria, antioxidants, and antimicrobial activities of growing male rabbits. A total of 100 California male weanling rabbits aged 35 days were divided into four nutritional treatments, each of which contained ANBBLCs at concentrations of 0 (control group), 50, 100, and 150 mg/kg diet (n = 25 per treatment, each replication consisting of one animal). The average body weight of the animals was 613 ± 14 g. The experiments lasted for 56 days. Dietary ANBBLC levels linearly improved (p < 0.05) the body weight, body weight gain, and feed conversion ratio (FCR) of rabbits. Furthermore, with increasing concentrations of ANBBLCs, the total antioxidant capacity of blood and liver tissue was linearly (p < 0.05) enhanced. Lactobacillus increased and Staphylococcus decreased (p < 0.05) in comparison to the control group when ANBBLC levels were added to the diets of rabbits. Rabbit diets supplemented with ANBBLCs increased dressing percentages and decreased abdominal fat. This study shows that ANBBLCs can be used as a feed additive to enhance the growth performance, carcass criteria, antioxidant, and antibacterial properties of growing rabbits.

20.
J Hand Surg Am ; 37(4): 832-6, 2012 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-22397844

RESUMEN

Complete ring avulsion injury necessitates a difficult choice between microvascular repair and revision amputation. Microvascular repair is technically difficult and amputation may leave an unsatisfactory result. We describe an alternative method whereby a reverse radial forearm flap is wrapped around the complete degloved digit. This provides good quality cover to the whole volar, dorsum, and both sides of the finger. We performed 26 pedicle radial forearm flaps for 26 patients in the Hand and Reconstructive Microsurgery Unit, Sohag University Hospital, from 2001 to 2009. Indications included soft tissue coverage of the thumb (n = 8), ring finger (n = 11), index finger (n = 4), middle finger (n = 2), and little finger (n = 1). Finger salvage was successful in 96% of patients. There was complete loss of 1 flap and partial flap loss of a second. Finger range of motion was excellent in 18 fingers, good in 7, and fair in 1. Two donor sites were closed primarily; the rest were closed with split-thickness skin grafts. There were no reports of cold intolerance of the hand or dysesthesias in the superficial radial nerve or lateral antebrachial nerve distribution.


Asunto(s)
Traumatismos de los Dedos/cirugía , Terapia Recuperativa , Colgajos Quirúrgicos/irrigación sanguínea , Adolescente , Adulto , Amputación Traumática , Desbridamiento , Femenino , Traumatismos de los Dedos/fisiopatología , Humanos , Masculino , Rango del Movimiento Articular , Procedimientos de Cirugía Plástica , Trasplante de Piel , Férulas (Fijadores) , Pulgar/lesiones , Adulto Joven
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