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1.
Discovery of novel cyclic peptide inhibitors of dengue virus NS2B-NS3 protease with antiviral activity.
Bioorg Med Chem Lett
; 27(15): 3586-3590, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28539222
2.
Discovery of novel 5-hydroxy-4-pyridone-3-carboxy acids as potent inhibitors of influenza Cap-dependent endonuclease.
Bioorg Med Chem Lett
; 26(19): 4739-4742, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27568084
3.
Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.
Bioorg Med Chem Lett
; 23(10): 2912-5, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23562056
4.
Conformational restriction approach to ß-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.
Bioorg Med Chem
; 21(21): 6506-22, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24051074
5.
Synthesis and structure-activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease.
Bioorg Med Chem Lett
; 19(1): 199-202, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19013793
6.
Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease.
J Med Chem
; 62(17): 8101-8114, 2019 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31386363
7.
Predicting human liver microsomal stability with machine learning techniques.
J Mol Graph Model
; 26(6): 907-15, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17683964
8.
Solid-state characterization of an NR2B selective N-methyl d-aspartate (NMDA) antagonist polymorphs.
Int J Pharm
; 355(1-2): 337-40, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18242021
9.
In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
Antiviral Res
; 160: 109-117, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30316915
10.
Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively.
Sci Rep
; 5: 8042, 2015 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-25622531
11.
Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics.
PLoS One
; 8(10): e77448, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24146996
12.
Conformational restriction approach to ß-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.
J Med Chem
; 55(20): 8838-58, 2012 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-22998419
13.
Predicting key example compounds in competitors' patent applications using structural information alone.
J Chem Inf Model
; 48(1): 135-42, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18177028
14.
Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation.
Bioorg Med Chem Lett
; 17(20): 5537-42, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17766107
15.
Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone--a potent NR2B-selective N-methyl D-aspartate (NMDA) antagonist for the treatment of pain.
Bioorg Med Chem Lett
; 17(20): 5558-62, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17766106
16.
Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity.
Bioorg Med Chem Lett
; 17(20): 5533-6, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17768047
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