1.
Chemistry
; 19(26): 8610-4, 2013 Jun 24.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23649592
RESUMEN
Blennolideâ A can be synthesized through an enantioselective domino-Wacker/carbonylation/methoxylation reaction of 7a with 96 % ee and an enantioselective Wacker oxidation of 7b with 89 % ee. Further transformations led to the α,ß-unsaturated ester (E)-17, which was subjected to a highly selective Michael addition, introducing a methyl group to give 18a. After a threefold oxidation and an intramolecular acylation, the tetrahydroxanthenone 4 was obtained, which could be transformed into (-)-blennolideâ A (ent-1) in a few steps.