RESUMEN
Objective The aim of this study was to compare position-related changes in fetal middle cerebral artery (MCA) Doppler pulsatility indices (PI). Methods A prospective study of 41 women with conditions associated with placental-pathology (chronic hypertension, pregestational diabetes, and abnormal analytes) and 34 women without those conditions was carried out. Fetal MCA Doppler velocity flow waveforms were obtained in maternal supine and left lateral decubitus positions. MCA PI Δ was calculated by subtracting the PI in the supine position from the PI in the left lateral position. Secondary outcomes included a composite of adverse perinatal outcomes (fetal growth restriction, oligohydramnios, and preeclampsia). χ2 and Student t-tests and repeated-measures analysis of variance were used. Results MCA PI Δ was significantly less for high-risk pregnant women ([P = 0.03]: high risk, left lateral PI, 1.90 ± 0.45 vs. supine PI, 1.88 ± 0.46 [Δ = 0.02]; low risk, left lateral PI, 1.90 ± 0.525 vs. supine PI, 1.68 ± 0.40 [Δ = 0.22]). MCA PI Δ was not significantly different between women who had a composite adverse outcome and women who did not have a composite adverse outcome (P = 0.843). Conclusion Our preliminary study highlights differences in position-related changes in fetal MCA PI between high-risk and low-risk pregnancies. These differences could reflect an attenuated ability of women with certain risk factors to respond to physiologic stress.
RESUMEN
BACKGROUND: Obesity has been linked to suboptimal bowel preparation but this association has not been conclusively investigated in prospective studies. GOALS: Our objective was to determine whether any relationship exists between obesity as measured by body mass index (BMI) and quality of bowel preparation. STUDY: Adult patients who presented for outpatient colonoscopy at a single urban ambulatory surgery center within a 6-month period and fulfilled inclusion criteria were prospectively enrolled for the study. Patients were divided by BMI into subcategories based on the World Health Organization international classification of obesity. The Modified Aronchick scale was used to assess bowel preparation for colonoscopy. A univariate and multivariate analysis was used to determine a possible association between BMI and poor preparation. RESULTS: A total of 1429 patients were evaluated. On the basis of inclusion criteria, 1314 subjects were analyzed, out of which 73% were overweight or obese. Inadequate bowel preparation was noted in 21.1% of patients. There was no correlation between obesity and the quality of the bowel preparation. Male gender (P=0.002), diabetes mellitus (P<0.0001), liver cirrhosis (P=0.001), coronary artery disease (P=0.003), refractory constipation (P<0.0001), and current smoking (P=0.01) were found to be independently predictive of poor bowel preparation. CONCLUSIONS: Increased BMI is not predictive of suboptimal bowel preparation for colonoscopy. The results of our study are pivotal given the increased risk of colorectal cancer in obese patients and their known lower rate of colorectal cancer screening in certain populations. It is important to avoid subjecting these patients to an intensive bowel preparation that may further discourage screening in a patient population that requires it.
Asunto(s)
Catárticos/administración & dosificación , Colonoscopía/métodos , Obesidad/epidemiología , Sobrepeso/epidemiología , Anciano , Índice de Masa Corporal , Neoplasias Colorrectales/diagnóstico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Factores de RiesgoRESUMEN
OBJECTIVE: Most soft tissue neck masses represent benign inflammatory or infectious processes; however, in some cases the diagnosis is not clear and a broader differential must be considered. The aim of this study was to compare point-of-care ultrasound (POCUS) to radiology department imaging (RDI) in the diagnosis of soft tissue neck masses. METHODS: This prospective pilot study involved a convenience sample of patients ranging in age from 1â¯month to 18â¯years of age presenting to the Pediatric Emergency Department (PED) with a soft tissue neck mass. All children who presented to the PED with soft tissue neck mass at times when an investigator was in the department, and who were candidates for enrollment, underwent a POCUS. The managing pediatric emergency medicine (PEM) provider determined whether RDI was indicated. The results of the POCUS sonologist and radiologist were compared. The kappa statistic was used to analyze agreement with pâ¯<â¯0.05 denoting statistical significance. RESULTS: Twenty-seven patients were enrolled into the study. Twenty-two received radiology ultrasound (RUS), 3 patients received CT, and 2 patients received both RUS and CT. There was agreement between POCUS and RDI diagnoses in 21/27 cases (78%). Accordingly, overall concordance between POCUS and RDI diagnoses was good: the kappa statistic comparing diagnoses obtained by POCUS versus RDI was 0.69 (pâ¯<â¯0.001). CONCLUSION: This prospective pilot study describes the reliability of POCUS as an imaging modality in the management of patients with undifferentiated soft tissue neck masses. POCUS demonstrated good agreement with RDI as a bedside imaging tool in the evaluation of pediatric soft tissue neck masses.
Asunto(s)
Neoplasias de Cabeza y Cuello/diagnóstico por imagen , Cuello/diagnóstico por imagen , Sistemas de Atención de Punto , Neoplasias de los Tejidos Blandos/diagnóstico por imagen , Ultrasonografía , Adolescente , Niño , Preescolar , Servicio de Urgencia en Hospital , Femenino , Humanos , Lactante , Masculino , Proyectos Piloto , Estudios Prospectivos , Reproducibilidad de los Resultados , Tomografía Computarizada por Rayos XRESUMEN
OBJECTIVE: Emergency Department patients with abdominal pain may require both an ultrasound (US) and computed tomography (CT) for an accurate diagnosis. Patients are often asked to drink oral radiocontrast while awaiting ultrasound, in order to better expedite a CT in the case of a non-diagnostic US. The impact of oral radiocontrast on US image quality has not been studied. We compared the quality of US images obtained before and after the ingestion of oral radiocontrast in healthy adult volunteers. METHODS: This was a prospective study in which adult volunteer subjects underwent sonographic studies of the aorta, the right upper quadrant, the right lower quadrant, and the Focused Assessment with Sonography in Trauma (FAST) examination. Initial studies were performed prior to ingestion of oral radiocontrast, with subsequent imaging occurring at 1 and 2hour post-ingestion. All of the images from the sonographic exams were randomized and subsequently scored for quality by two emergency ultrasound fellowship trained emergency physicians with extensive experience in performing and interpreting US. RESULTS: 638 images from 240 exams were obtained from 20 subjects at three time points. Six exams were not scored due to inadequate images. There were no significant differences in image quality for any of the US exam types after the ingestion of oral radiocontrast at 1 and 2h. CONCLUSION: Ingestion of oral radiocontrast did not affect image quality of four common abdominal ultrasound examinations.
Asunto(s)
Abdomen/diagnóstico por imagen , Medios de Contraste/administración & dosificación , Dolor Abdominal/diagnóstico por imagen , Aorta/diagnóstico por imagen , Servicio de Urgencia en Hospital , Humanos , Estudios Prospectivos , Factores de Tiempo , Tomografía Computarizada por Rayos X/métodos , Ultrasonografía/normasRESUMEN
STUDY OBJECTIVE: Nonsteroidal anti-inflammatory drugs are used extensively for the management of acute and chronic pain, with ketorolac tromethamine being one of the most frequently used parenteral analgesics in the emergency department (ED). The drugs may commonly be used at doses above their analgesic ceiling, offering no incremental analgesic advantage while potentially adding risk of harm. We evaluate the analgesic efficacy of 3 doses of intravenous ketorolac in ED patients with acute pain. METHODS: We conducted a randomized, double-blind trial to assess the analgesic efficacy of 3 doses of intravenous ketorolac (10, 15, and 30 mg) in patients aged 18 to 65 years and presenting to the ED with moderate to severe acute pain, defined by a numeric rating scale score greater than or equal to 5. We excluded patients with peptic ulcer disease, gastrointestinal hemorrhage, renal or hepatic insufficiency, allergies to nonsteroidal anti-inflammatory drugs, pregnancy or breastfeeding, systolic blood pressure less than 90 or greater than 180 mm Hg, and pulse rate less than 50 or greater than 150 beats/min. Primary outcome was pain reduction at 30 minutes. We recorded pain scores at baseline and up to 120 minutes. Intravenous morphine 0.1 mg/kg was administered as a rescue analgesic if subjects still desired additional pain medication at 30 minutes after the study drug was administered. Data analyses included mixed-model regression and ANOVA. RESULTS: We enrolled 240 subjects (80 in each dose group). At 30 minutes, substantial pain reduction was demonstrated without any differences between the groups (95% confidence intervals 4.5 to 5.7 for the 10-mg group, 4.5 to 5.6 for the 15-mg group, and 4.2 to 5.4 for the 30-mg group). The mean numeric rating scale pain scores at baseline were 7.7, 7.5, and 7.8 and improved to 5.1, 5.0, and 4.8, respectively, at 30 minutes. Rates of rescue analgesia were similar, and there were no serious adverse events. Secondary outcomes showed similar rates of adverse effects per group, of which the most common were dizziness, nausea, and headache. CONCLUSION: Ketorolac has similar analgesic efficacy at intravenous doses of 10, 15, and 30 mg, showing that intravenous ketorolac administered at the analgesic ceiling dose (10 mg) provided effective pain relief to ED patients with moderate to severe pain without increased adverse effects.
Asunto(s)
Dolor Agudo/tratamiento farmacológico , Antiinflamatorios no Esteroideos/administración & dosificación , Antiinflamatorios no Esteroideos/uso terapéutico , Servicio de Urgencia en Hospital , Ketorolaco/administración & dosificación , Ketorolaco/uso terapéutico , Dolor Agudo/fisiopatología , Adulto , Antiinflamatorios no Esteroideos/farmacología , Relación Dosis-Respuesta a Droga , Método Doble Ciego , Femenino , Humanos , Inyecciones Intravenosas , Ketorolaco/farmacología , Masculino , Dimensión del Dolor , Resultado del TratamientoRESUMEN
BACKGROUND: Pediatric appendicitis is a common, potentially serious condition. Determining perforation status is crucial to planning effective management. PURPOSE: Determine the efficacy of serum total bilirubin concentration [STBC] in distinguishing perforation status in children with appendicitis. METHODS: Retrospective review of 257 cases of appendicitis who received abdominal CT scan and measurement of STBC. RESULTS: There were 109 with perforation vs 148 without perforation. Although elevated STBC was significantly more common in those with [36%] vs without perforation [22%], the mean difference in elevated values between groups [0.1mg/dL] was clinically insignificant. Higher degrees of hyperbilirubinemia [>2mg/dL] were rarely encountered [5%]. Predictive values for elevated STBC in distinguishing perforation outcome were imprecise [sensitivity 38.5%, specificity 78.4%, PPV 56.8%, NPV 63.4%]. ROC curve analysis of multiple clinical and other laboratory factors for predicting perforation status was unenhanced by adding the STBC variable. Specific analysis of those with perforated appendicitis and percutaneously-drained intra-abdominal abscess which was culture-positive for Escherichia coli showed an identical rate of STBC elevation compared to all with perforation. CONCLUSIONS: The routine measurement of STBC does not accurately distinguish perforation status in children with appendicitis, nor discern infecting organism in those with perforation and intra-abdominal abscess.
Asunto(s)
Absceso Abdominal/sangre , Absceso Abdominal/diagnóstico , Apendicitis/sangre , Apendicitis/diagnóstico , Bilirrubina/sangre , Adolescente , Niño , Preescolar , Diagnóstico Diferencial , Femenino , Humanos , Hiperbilirrubinemia/epidemiología , Masculino , Valor Predictivo de las Pruebas , Curva ROC , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Estados UnidosRESUMEN
STUDY OBJECTIVE: Compare adverse effects and analgesic efficacy of low-dose ketamine for acute pain in the ED administered either by single intravenous push (IVP) or short infusion (SI). METHODS: Patients 18-65, presenting to ED with acute abdominal, flank, or musculoskeletal pain with initial pain score≥5, were randomized to ketamine 0.3mg/kg by either IVP or SI with placebo double-dummy. Adverse effects were evaluated by Side Effects Rating Scale for Dissociative Anesthetics (SERSDA) and Richmond Agitation-Sedation Scale (RASS) at 5, 15, 30, 60, 90, and 120min post-administration; analgesic efficacy was evaluated by Numerical Rating Scale (NRS). RESULTS: 48 patients enrolled in the study. IVP group had higher overall rates of feeling of unreality on SERSDA scale: 92% versus 54% (difference 37.5%; p=0.008; 95% CI 9.3-59.5%). At 5min median severity of feeling of unreality was 3.0 for IVP versus 0.0 for SI (p=0.001). IVP also showed greater rates of sedation on RASS scale at 5min: median RASS -2.0 versus 0.0 (p=0.01). Decrease in mean pain scores from baseline to 15min was similar across groups: 5.2±3.53 (95% CI 3.7-6.7) for IVP; 5.75±3.48 (95% CI 4.3-7.2) for SI. There were no statistically significant differences with respect to changes in vital signs and need for rescue medication. CONCLUSION: Low-dose ketamine given as a short infusion is associated with significantly lower rates of feeling of unreality and sedation with no difference in analgesic efficacy in comparison to intravenous push.
Asunto(s)
Dolor Agudo/tratamiento farmacológico , Analgésicos/administración & dosificación , Analgésicos/uso terapéutico , Servicio de Urgencia en Hospital , Ketamina/administración & dosificación , Ketamina/uso terapéutico , Adulto , Relación Dosis-Respuesta a Droga , Método Doble Ciego , Femenino , Humanos , Infusiones Intravenosas , Masculino , Dimensión del Dolor , Estudios Prospectivos , Resultado del Tratamiento , Estados UnidosRESUMEN
Objective The objective of this study was to investigate the association between contrast enema (CE) and clinical sepsis (CS) in premature babies (PB) and the role of antibiotics (ABs) in its prevention. Study Design A retrospective electronic chart review of preterm babies, who underwent CE during their stay in the neonatal intensive care unit. Group I includes CEs of babies exposed to AB during or within 48 hours of the procedure. Group II represents CEs of babies, not exposed to AB. Variables for both groups were collected and analyzed. Results There were 161 CEs performed in 133 babies. The overall incidence of CS after CE in preterm babies was 21/160 cases (13%). The incidence was significantly lower in Group I (1/79, 1.2%), compared with Group II (20/81, 24.7%) (p < 0.001). Six (30%) of the 20 babies from Group II had positive blood culture and all 20 required AB after the CE. There were no statistical differences in the variables between the two groups. Conclusion There is a possible association between CE and CS in preterm babies. ABs given during or before the procedure prevent this complication.
Asunto(s)
Antibacterianos/uso terapéutico , Enema/efectos adversos , Sepsis/epidemiología , Sulfato de Bario/efectos adversos , Cultivo de Sangre , Medios de Contraste/efectos adversos , Femenino , Humanos , Incidencia , Recién Nacido , Recien Nacido Prematuro , Masculino , Estudios Retrospectivos , Factores de Riesgo , Sepsis/etiologíaRESUMEN
Intimate Partner Abuse (IPA), a major social problem, can lead to mental health conditions and is implicated in 30 % of female and 5 % of male homicide deaths. We hypothesized that due to distinct relationship structures and power dynamics which are immersed in varying sociocultural contexts, victims of male-male, female-female and female-male dyads experience different patterns of IPA. Our objectives were: (1) To examine the demographic and clinical characteristics of victims of male victim-male abuser (M-M), female victim-male abuser (F-M), male victim-female abuser (M-F), and female victim-female abuser (F-F) dyads. (2) To compare patterns of IPA reported by the victims in these groups. Out of 397 subjects in the general population that attempted this Internet-based study, 214 English-speaking subjects were older than 18 years, had experienced IPA, and provided complete information for the analysis. Victims of IPA were screened and specific methods of abuse were evaluated. M-Ms were significantly more educated (70 %) than other groups. F-Fs experienced more abuse before age 18 by a parent or relative. F-Fs experienced the most physical abuse while M-Ms the least (p = 0.004). Physical abuse or threats of abuse in front of children was reported more in F-Fs (p < 0.01) and least in M-Ms. IPA patterns differ significantly with F-Fs presenting the most physical profile and M-Ms presenting the least.
Asunto(s)
Relaciones Interpersonales , Violencia de Pareja/psicología , Minorías Sexuales y de Género/psicología , Adultos Sobrevivientes del Maltrato a los Niños/psicología , Adultos Sobrevivientes del Maltrato a los Niños/estadística & datos numéricos , Femenino , Humanos , Violencia de Pareja/estadística & datos numéricos , Masculino , Estudios Prospectivos , Estados Unidos , Adulto JovenRESUMEN
PURPOSE: The primary purpose of our study was to determine if there is a difference in the occurrence of hospital-acquired pressure injuries (HAPIs) and incontinence-associated dermatitis (IAD) in incontinent adults using a disposable versus reusable absorptive underpads. We also compared hospital length of stay in the 2 groups. DESIGN: Randomized controlled trial using cluster randomization based on inpatient care unit. SUBJECTS AND SETTING: Four hundred sixty-two patients admitted to 4 medical-surgical study units participated in the study; 252 used reusable underpads (control group) and 210 subjects used disposable underpads (intervention group). The study setting was a 711-bed acute care hospital located in Brooklyn, New York. METHODS: Two units were randomly allocated to use disposable incontinence pads, and the remaining 2 units used standard, reusable incontinence pads. Data for PI and IAD occurrences were collected weekly by specially trained RNs (skin care champions) on the assigned units. A 2-level hierarchical linear model was used to analyze the effects of the intervention on primary and secondary outcomes separately from any effects of the unit of randomization. RESULTS: HAPIs were significantly lower in the disposable underpads group: 5% versus 12% (P = .02). Rates of hospital IAD were not significantly different between the groups (P = .22). Analysis of a secondary outcome, hospital length of stay, was also lower in patients who used disposable underpads (6 days vs 8 days; P = .02). CONCLUSIONS: Findings suggest that use of disposable incontinence pads reduces HAPI but not IAD occurrences. The effect of disposable, absorbent incontinence pads should be considered when initiating a hospital-wide skin and PI prevention and treatment plan.
Asunto(s)
Almohadillas Absorbentes/normas , Dermatitis/prevención & control , Pañales para la Incontinencia/normas , Úlcera por Presión/prevención & control , Almohadillas Absorbentes/estadística & datos numéricos , Anciano , Anciano de 80 o más Años , Dermatitis/etiología , Femenino , Humanos , Enfermedad Iatrogénica/prevención & control , Pañales para la Incontinencia/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Ciudad de Nueva York , Úlcera por Presión/etiología , Estadísticas no Paramétricas , Incontinencia Urinaria/complicacionesRESUMEN
OBJECTIVE: The authors sought to assess the documentation of suicide risk assessments performed by psychiatry residents in a psychiatric emergency service (PES) and to identify differences in documentation between previously used paper charts and a new electronic medical record (EMR) system based on the Columbia Suicide Severity Rating Scale (C-SSRS)-risk assessment version. METHODS: This study is a retrospective chart review of psychiatric evaluations performed by psychiatry residents during a 1-year period in the PES of a large, urban, academic medical center. The sample was selected by a systematic random sampling technique from a total of 3931 evaluations performed on adult patients during the study period. The suicide risk assessments were evaluated using data regarding demographics, process indicators identified from the C-SSRS, and diagnoses. RESULTS: A total of 300 charts were reviewed. Only 91% of the evaluations contained documentation of suicidal ideations (either admitted or denied); 5 other variables were documented in more than 50% of the evaluations: treatment status (95.3%), presence/absence of previous suicide attempts (84.6%), recent event-denies (56%), history of recent negative events (55%), and suicidal behavior-denies (53%). Additionally, 2 risk factors and 3 protective factors were documented in over 25% of the evaluations. CONCLUSION: Documentation was deficient in multiple areas, with even the presence/absence of suicidal ideations not being documented in all evaluations. Use of an EMR with built-in "clickable" options selectively improved documentation especially regarding risk and protective factors adapted from the C-SSRS. Emphasis on documentation of assessments is paramount while training residents in suicide risk assessment.
Asunto(s)
Servicios de Urgencia Psiquiátrica/métodos , Internado y Residencia , Registros Médicos/estadística & datos numéricos , Ideación Suicida , Intento de Suicidio/estadística & datos numéricos , Adulto , Femenino , Humanos , Masculino , Escalas de Valoración Psiquiátrica , Estudios Retrospectivos , Medición de Riesgo , Factores de Riesgo , Estados UnidosRESUMEN
OBJECTIVES: Clostridium difficile caused nearly 500,000 infections and was associated with approximately 29,000 deaths in 2011, according to data from the Centers for Disease Control and Prevention. C. difficile is a bacterium that causes diarrhea and, often, severe illness in healthcare facilities, as well as the community. Our objective was to determine whether alkaline colonic pH predisposes to colonization and infection with C. difficile. METHODS: A total of 228 patients with diarrhea and/or abdominal pain, leukocytosis, and fever were included. Stool pH was measured, and C. difficile antigen and toxin in stool were detected. RESULTS: Of 228 patients, 30 (13.2%) tested positive for C. difficile (antigen+/toxin+) and 171 (75%) were C. difficile negative (antigen-/toxin-). Of 171 patients who tested negative, 93 (54.4%) had stool pH >7.0 and 78 (45.6%) had pH ≤7.0. Among the 30 patients who tested positive, 26 (86.7%) had stool pH >7.0 (P = 0.002). Among the 27 colonized patients (antigen+/toxin-), 12 (44.4%) had stool pH >7.0 (P = 0.34). For all patients with stool pH ≤7.0, 96% tested negative for C. difficile infection (P = 0.002). CONCLUSIONS: A strong association between C. difficile infection and alkaline stool pH was found.
Asunto(s)
Colon/microbiología , Enterocolitis Seudomembranosa/etiología , Secreciones Intestinales/fisiología , Anciano , Clostridioides difficile/fisiología , Colon/fisiopatología , Diarrea/etiología , Diarrea/microbiología , Diarrea/fisiopatología , Heces/microbiología , Femenino , Humanos , Concentración de Iones de Hidrógeno , Secreciones Intestinales/microbiología , Masculino , Estudios Prospectivos , Factores de RiesgoRESUMEN
OBJECTIVES: This study aimed to analyze a large group of febrile neonates 28 days or younger who received outpatient sepsis evaluation and nasopharyngeal aspirate antigen testing (NPAT) for respiratory syncytial viral (RSV) infection to determine whether there is a clinically significant association between viral study results and risk for serious bacterial infection (SBI: bacterial meningitis, bacteremia, urinary tract infection, bacterial enteritis). METHODS: We evaluated consecutive febrile neonates 28 days or younger presenting to our urban pediatric emergency department [Maimonides Medical Center (MMC)] during a 6-year period, all of whom received a sepsis evaluation (cerebrospinal fluid, blood, urine cultures) and RSV NPAT. To achieve adequate power (80%), the MMC data were combined with similar data reported from a prior prospective PEM-CRC study of like-aged febrile neonates who received similar evaluation. RESULTS: From the MMC data of consecutively evaluated cases, the prevalence rate of +RSV in 387 febrile neonates was 6%. Of these, 378 (98%) received both a sepsis evaluation and RSV NPAT; +SBI occurred in 4/22 (18.1%) with +RSV versus 58/356 (16.2%) with -RSV (P = 0.77). Combined with the PEM-CRC cohort of 411 febrile neonates 28 days or younger who received similar evaluation, a total of 789 cases were analyzed using meta-analysis. Overall, there were 117 (14.8%) cases of +SBI and 104 (13.2%) cases of +RSV. The rate of +SBI was 11.5% in those with +RSV versus 15.3% in those with -RSV. Meta-analysis performed showed no significant difference in rates of +SBI between those with and without +RSV (odds ratio, 0.78; 95% confidence interval, 0.41-1.50; P = 0.46). CONCLUSIONS: Rates of +SBI are not significantly different between febrile neonates 28 days or younger with and without +RSV. Respiratory viral infection status is not an accurate clinical determinant in distinguishing SBI risk in febrile neonates.
Asunto(s)
Infecciones por Virus Sincitial Respiratorio/complicaciones , Sepsis/diagnóstico , Sepsis/microbiología , Diagnóstico Diferencial , Fiebre/epidemiología , Fiebre/microbiología , Humanos , Recién Nacido , Ciudad de Nueva York/epidemiología , Prevalencia , Infecciones por Virus Sincitial Respiratorio/epidemiología , Estudios Retrospectivos , Medición de Riesgo , Sepsis/epidemiologíaRESUMEN
Restraint use in psychiatry has been a topic of clinical and ethical debate for years. As much as the medical community desires to attain the goal of a restraint-free environment, there are not many alternatives available when it comes to protecting the safety of violent patients and those around them. Our objective was to examine patterns of restraint use and analyze the factors leading to its use in adult psychiatric inpatient units. We conducted a retrospective review of restraint orders from January 2007 to December 2012, for inpatient units at a community mental health hospital, examining-unit, patient gender, number and duration of restraint episodes, time of day, and whether medications and/or verbal redirection were used. For the 6-year period studied, a total of 1753 restraint order-sheets were filed for 455 patients. Mixed-model regression found significant differences in duration of restraint episodes depending on: patient gender, unit, medication use, verbal redirection and AM/PM shifts. These differences were consistent over time with no significant interactions with years and remained significant when included together in an overall multivariate model. We elucidate variable patterns of restraint utilization correlating with elements such as patient gender, time of day and staff shift, medication use, and attempts at verbally redirecting the patient. Besides providing much needed data on the intricate dynamics influencing restraint use, we suggest steps to implement hospital-wide restraint-reduction initiatives including cultural changes related to restraint usage, enhanced staff-training in conflict de-escalation techniques and personalized treatment plans for foreseeable restraint episodes.
Asunto(s)
Hospitales Comunitarios , Hospitales Psiquiátricos , Restricción Física/estadística & datos numéricos , Utilización de Medicamentos/estadística & datos numéricos , Femenino , Humanos , Pacientes Internos , Masculino , Análisis de Regresión , Estudios Retrospectivos , Factores Sexuales , Factores de TiempoRESUMEN
STUDY OBJECTIVE: We assess and compare the analgesic efficacy and safety of subdissociative intravenous-dose ketamine with morphine in emergency department (ED) patients. METHODS: This was a prospective, randomized, double-blind trial evaluating ED patients aged 18 to 55 years and experiencing moderate to severe acute abdominal, flank, or musculoskeletal pain, defined as a numeric rating scale score greater than or equal to 5. Patients were randomized to receive ketamine at 0.3 mg/kg or morphine at 0.1 mg/kg by intravenous push during 3 to 5 minutes. Evaluations occurred at 15, 30, 60, 90, and 120 minutes. Primary outcome was reduction in pain at 30 minutes. Secondary outcome was the incidence of rescue analgesia at 30 and 60 minutes. RESULTS: Forty-five patients per group were enrolled in the study. The primary change in mean pain scores was not significantly different in the ketamine and morphine groups: 8.6 versus 8.5 at baseline (mean difference 0.1; 95% confidence interval -0.46 to 0.77) and 4.1 versus 3.9 at 30 minutes (mean difference 0.2; 95% confidence interval -1.19 to 1.46; P=.97). There was no difference in the incidence of rescue fentanyl analgesia at 30 or 60 minutes. No statistically significant or clinically concerning changes in vital signs were observed. No serious adverse events occurred in either group. Patients in the ketamine group reported increased minor adverse effects at 15 minutes post-drug administration. CONCLUSION: Subdissociative intravenous ketamine administered at 0.3 mg/kg provides analgesic effectiveness and apparent safety comparable to that of intravenous morphine for short-term treatment of acute pain in the ED.
Asunto(s)
Analgesia/métodos , Analgésicos Opioides , Anestésicos Disociativos , Servicio de Urgencia en Hospital , Ketamina , Morfina , Dimensión del Dolor/métodos , Dolor Agudo , Adulto , Analgésicos Opioides/administración & dosificación , Anestésicos Disociativos/administración & dosificación , Método Doble Ciego , Femenino , Humanos , Inyecciones Intravenosas , Ketamina/administración & dosificación , Masculino , Morfina/administración & dosificación , TiempoAsunto(s)
Competencia Clínica , Ecocardiografía , Educación de Postgrado en Medicina/métodos , Medicina de Emergencia/educación , Insuficiencia Cardíaca/diagnóstico , Internado y Residencia/métodos , Volumen Sistólico/fisiología , Insuficiencia Cardíaca/fisiopatología , Humanos , New York , Reproducibilidad de los ResultadosRESUMEN
OBJECTIVE: The purpose of this study was to evaluate levels of spiritual well-being over time in populations with advanced congestive heart failure (CHF) or chronic obstructive lung disease (COPD). METHOD: In a prospective, longitudinal study, patients with CHF or COPD (each n = 103) were interviewed at baseline and every 3 months for up to 30 months. At each interview, patients completed: the basic faith subscale of the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being (FACIT-Sp) questionnaire, the Memorial Symptom Assessment Scale (MSAS), the Rand Mental Health Inventory (MHI), the Multidimensional Index of Life Quality (MILQ), the Sickness Impact Profile (SIP), and the Short Portable Mental Health Questionnaire (SPMSQ). RESULT: The mean age was 65 years, 59% were male, 78% were Caucasian, 50% were married, 29% lived alone, and there was no significant cognitive impairment. Baseline median FACIT-Sp score was 10.0 on a scale of 0-16. FACIT-Sp scores did not change over time and multivariate longitudinal analysis revealed higher scores for black patients and lower scores for those with more symptom distress on the MSAS-Global Distress Index (GDI) (both p = 0.02). On a separate multivariate longitudinal analysis, MILQ scores were positively associated with the FACIT-Sp and the MHI, and negatively associated with the MSAS-GDI and the SIP (all p-values < 0.001). SIGNIFICANCE OF RESULTS: In advanced CHF and COPD, spiritual well-being remains stable over time, it varies by race and symptom distress, and contributes to quality of life, in combination with symptom distress, mental health and physical functioning.
Asunto(s)
Insuficiencia Cardíaca/psicología , Enfermedad Pulmonar Obstructiva Crónica/psicología , Espiritualidad , Adaptación Psicológica , Anciano , Boston , Comorbilidad , Femenino , Humanos , Entrevistas como Asunto , Estudios Longitudinales , Masculino , Ciudad de Nueva York , Estudios Prospectivos , Calidad de Vida , Encuestas y CuestionariosRESUMEN
BACKGROUND: Little is known about cancer pain in Chinese Americans. The objective of this study was to describe the epidemiology of pain in this population. This information is needed to identify and address unmet clinical needs for culturally relevant interventions targeting pain and its consequences. METHODS: A consecutive sample of underserved ethnic Chinese patients in a large community-based oncology practice was screened for persistent or frequent pain. Those patients with pain completed translated instruments assessing demographics, linguistic acculturation, disease-related characteristics, and pain-related characteristics. RESULTS: Of 312 patients screened, 178 (57.1%) reported frequent or persistent pain, 175 were eligible, and 170 participated. Most participants (85.9%) were born in China and 84.7% overall spoke Cantonese only. The most common cancers were gastrointestinal (28.2%), lung (21.8%), breast (20.6%), head and neck (12.9%), and genitourinary (4.7%); 43.5% had metastatic disease. The mean worst pain severity on a 0-10 numeric scale was 4.7 (standard deviation, 2.4), with 28.2% of patients rating their worst pain at ≥7 of 10. Although 37.6% used opioids and 47.1% used nonopioids, 45.8% reported "little" or "no" pain relief from medications. Complementary or alternative medicine therapies for cancer pain were used by 35.8%. In multiple regression analyses, worst pain was positively associated with acculturation to the English language and opioid therapy, and pain-related distress was positively associated with opioid therapy. CONCLUSION: Pain is prevalent among community-dwelling, ethnic Chinese American cancer patients. Additional studies are needed to confirm these results and investigate the finding that higher linguistic acculturation is associated with reports of more intense pain.
Asunto(s)
Asiático , Neoplasias/fisiopatología , Dimensión del Dolor , Dolor/etnología , Poblaciones Vulnerables , Femenino , Disparidades en Atención de Salud , Humanos , Masculino , Área sin Atención Médica , Neoplasias/etnología , Neoplasias/etiología , Dolor/complicaciones , Dolor/tratamiento farmacológico , Encuestas y CuestionariosRESUMEN
OBJECTIVES: The aims of this study were to determine predictors of survival after hospital discharge and to describe the impact of intensive care unit admission on health-related quality of life at 6 months after hospital discharge in older adults admitted to intensive care units. DESIGN: Prospective longitudinal observational study with administered questionnaire. SETTINGS AND PATIENTS: Patients 65 yrs of age and older who were admitted to the medical, surgical, and coronary intensive care units for >24 hrs in a large urban teaching hospital system from August 2007 to May 2008 with a follow-up period ending April 2009. INTERVENTIONS: Administered questionnaire to patients or proxies. MEASUREMENTS AND MAIN RESULTS: Four hundred eighty-four patients 65 yrs old and older were enrolled. Data were collected on demographics, comorbidities, intensive care unit admission diagnoses, Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment score, Glasgow Coma Scale score at intensive care unit admission, intensive care unit interventions, and disposition after hospital discharge. A health-related quality of life survey was administered to patients, their proxies, or caregivers at intensive care unit admission, and to hospital survivors at 6 months after hospital discharge. Three hundred sixty-seven (75.8%) and 318 (65.7%) of enrolled patients were alive at hospital discharge and at 6 months, respectively. Mean age of survivors was 77.8 ± 8.5. Independent predictors of death at 6 months were: number of days during the 30 days before hospitalization that the patient felt their "physical health was not good" on the health-related quality of life survey [odds ratio = 1.08; confidence interval 1.04-1.12], a higher Acute Physiology and Chronic Health Evaluation II score [odds ratio = 1.09; 95% confidence interval 1.06-1.12], and chronic pulmonary disease as a comorbidity [odds ratio = 2.22; 95% confidence interval 1.04-4.78]. Of the 318 survivors at 6 months after hospital discharge, 297 (93.4%) completed the health-related quality of life questionnaire. When assessing whether changes in health-related quality of life over time were affected by age in our study cohort of 65 yrs old and older, we found that the oldest survivors, age 86.3 yrs old and older, had worse health-related quality of life over time, including more days spent with poor physical health (p < .004) and mental health (p < .001), while the youngest survivors, age 65-69.3 yrs old, showed improvement in health-related quality of life with fewer days spent with poor physical health (p < .004) and mental health (p < .001) at follow-up compared to baseline. These differences remained after adjusting for severity of illness and other potential confounders. CONCLUSIONS: One-third of adults 65 yrs old and older admitted to the intensive care unit die within 6 months of hospital discharge. Among survivors at 6 months, health-related quality of life has significantly worsened over time in the oldest patients but improved in the youngest. Our study in a large cohort of mixed intensive care unit patients identifies additional prognostic factors and significant quality of life information in intensive care unit survivors well after hospital discharge. This additional information may guide clinicians in their discussions with patients, families, and other providers as they decide on what treatments and interventions to pursue.
Asunto(s)
Unidades de Cuidados Intensivos/estadística & datos numéricos , Calidad de Vida , Factores de Edad , Anciano , Anciano de 80 o más Años , Distribución de Chi-Cuadrado , Femenino , Escala de Coma de Glasgow , Humanos , Modelos Logísticos , Estudios Longitudinales , Masculino , Oportunidad Relativa , Alta del Paciente/estadística & datos numéricos , Calidad de Vida/psicología , Curva ROC , Índice de Severidad de la Enfermedad , Estadísticas no Paramétricas , Encuestas y Cuestionarios , Factores de Tiempo , Resultado del TratamientoRESUMEN
PURPOSE: The purpose of this study was to test the effectiveness of an integrative medicine approach to the management of asthma compared to standard clinical care on quality of life (QOL) and clinical outcomes. METHODS: This was a prospective parallel group repeated measurement randomized design. Participants were adults aged 18 to 80 years with asthma. The intervention consisted of six group sessions on the use of nutritional manipulation, yoga techniques, and journaling. Participants also received nutritional supplements: fish oil, vitamin C, and a standardized hops extract. The control group received usual care. Primary outcome measures were the Asthma Quality of Life Questionnaire (AQLQ), The Medical Outcomes Study Short Form-12 (SF-12), and standard pulmonary function tests (PFTs). RESULTS: In total, 154 patients were randomized and included in the intention-to-treat analysis (77 control, 77 treatment). Treatment participants showed greater improvement than controls at 6 months for the AQLQ total score (P<.001) and for three subscales, Activity (P< 0.001), Symptoms (P= .02), and Emotion (P<.001). Treatment participants also showed greater improvement than controls on three of the SF-12 subscales, Physical functioning (P=.003); Role limitations, Physical (P< .001); and Social functioning (P= 0.03), as well as in the aggregate scores for Physical and Mental health (P= .003 and .02, respectively). There was no change in PFTs in either group. CONCLUSION: A low-cost group-oriented integrative medicine intervention can lead to significant improvement in QOL in adults with asthma.