Detalles de la búsqueda
1.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26046436
2.
In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule ent-Verticilide.
J Pharmacol Exp Ther
; 385(3): 205-213, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36894328
3.
Discovery, synthesis and biological evaluation of a series of N-(phenylcarbamothioyl)-2-napthamides as inhibitors of Claudin-1.
Bioorg Med Chem
; 92: 117416, 2023 09 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37541070
4.
Bidirectional influence of limbic GIRK channel activation on innate avoidance behavior.
J Neurosci
; 2021 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34039657
5.
Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists.
Bioorg Med Chem Lett
; 61: 128615, 2022 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35151866
6.
Characterization of VU0468554, a New Selective Inhibitor of Cardiac G Protein-Gated Inwardly Rectifying K+ Channels.
Mol Pharmacol
; 100(6): 540-547, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34503975
7.
Virtual screening and biological evaluation of PPARγ antagonists as potential anti-prostate cancer agents.
Bioorg Med Chem
; 46: 116368, 2021 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34433102
8.
Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors.
Bioorg Med Chem Lett
; 30(18): 127418, 2020 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32750526
9.
Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903.
Bioorg Med Chem Lett
; 29(2): 155-159, 2019 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30538066
10.
Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators.
Bioorg Med Chem Lett
; 29(6): 791-796, 2019 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30718161
11.
The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate.
Bioorg Med Chem Lett
; 29(2): 342-346, 2019 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30503632
12.
Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992.
Mol Pharmacol
; 94(2): 926-937, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29895592
13.
Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability.
Bioorg Med Chem Lett
; 28(15): 2641-2646, 2018 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29958762
14.
Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.
Chem Rev
; 116(11): 6707-41, 2016 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26882314
15.
Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus.
J Neurosci
; 35(19): 7600-15, 2015 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25972184
16.
Validation of an improved scale for rating l-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists.
Neurobiol Dis
; 96: 156-170, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27597526
17.
Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists.
Bioorg Med Chem Lett
; 26(23): 5757-5764, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28327307
18.
Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4).
Bioorg Med Chem Lett
; 26(13): 2984-2987, 2016 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27234146
19.
Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.
Bioorg Med Chem Lett
; 26(10): 2481-2488, 2016 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27080176
20.
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy.
Bioorg Med Chem Lett
; 26(12): 2915-2919, 2016 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27131990