RESUMEN
PURPOSE: This study evaluated the osteogenetic capability of Ling Zhi-8 (LZ-8; a protein purified from traditional Chinese medicine [lingzhi]) compared with recombinant human bone morphogenic protein-2 (rhBMP-2) in a standardized bony defect using a rabbit sinus model. MATERIALS AND METHODS: Twelve male New Zealand white rabbits (18 to 24 weeks old, 3.3 to 3.8 kg) were included in the study. Implants of normal saline 0.1 mg, rhBMP-2 0.1 mg, and LZ-8 0.1 mg were each mixed with a uniform biodegradable polyurethane-based material (Nasopore). The implants were inserted in a standardized bony defect of the nasal bone created by a 2.5-mm trephine bur. The rabbits were sacrificed at 1, 2, 4, and 8 weeks postoperatively. Volume computerized tomographic and histomorphometric examinations were used to evaluate the quantity and quality of regenerated bone. RESULTS: At postoperative week 4, radiography showed that the new bone volume was significantly larger in the rhBMP-2 group compared with the LZ-8 group (P = .041) and the control group (P = .015). Histomorphometrically, better wound healing of the rhBMP-2 group was found during the healing phase compared with the other 2 groups. CONCLUSION: The biomaterial implants using rhBMP-2 and LZ-8 had good biocompatibility and osteogenetic capabilities in the rabbit sinus model. Bone healing in rhBMP-2-treated defects was excellent and showed a significant difference compared with LZ-8. However, LZ-8-treated defects also exhibited bone regeneration, and this traditional Chinese medicine may possess osteogenic potential. Further investigations of the mechanism and application of this protein in osteogenesis are needed.
Asunto(s)
Proteína Morfogenética Ósea 2/uso terapéutico , Medicamentos Herbarios Chinos/uso terapéutico , Proteínas Fúngicas/uso terapéutico , Hueso Nasal/cirugía , Enfermedades Nasales/cirugía , Osteogénesis/efectos de los fármacos , Factor de Crecimiento Transformador beta/uso terapéutico , Implantes Absorbibles , Animales , Materiales Biocompatibles/química , Densidad Ósea/efectos de los fármacos , Regeneración Ósea/efectos de los fármacos , Modelos Animales de Enfermedad , Portadores de Fármacos , Humanos , Imagenología Tridimensional/métodos , Masculino , Hueso Nasal/efectos de los fármacos , Neovascularización Fisiológica/efectos de los fármacos , Poliuretanos/química , Conejos , Proteínas Recombinantes/uso terapéutico , Factores de Tiempo , Tomografía Computarizada por Rayos X/métodos , Cicatrización de Heridas/efectos de los fármacosRESUMEN
Heterotopic salivary gland tissue is salivary tissue located outside the sites generally known to accommodate major and minor salivary glands. Although heterotopic salivary tumors were reported in various regions of the head and neck, they are seldom found in the superio-posterior neck region and can be confused with other neck masses. Herein, we present a rare case of a heterotopic pleomorphic adenoma in the postauricular area and remind clinicians that heterotopic salivary tumors should be in the differential diagnosis of neck masses.