Research on the pre-pulses caused by post-pulses in the optical parametric chirped-pulse amplifier.

Pre-pulses caused by the post-pulses in the optical parametric chirped-pulse amplifier were comprehensively studied for the first time, including the underlying mechanism for the delay-shift of pre-pulses, the intensity variation of pre-pulses affected by the initial delay of post-pulses and the pump energy, and also the nonlinear beat noise. The simulation and measurement confirmed that the high-order dispersion of the pulse stretcher was the main cause for the delay-shift of pre-pulses, which should be similar with the chirped-pulse amplifiers. The intensity of pre-pulses would decrease significantly as the initial delay of post-pulses increased, but would increase with the growth of pump energy. Moreover, the temporal position of the nonlinear beat noise in the experiment was successfully predicted by our simulation. This work could help us better understand the pre-pulses in OPCPA and provide helpful guidance for designing high-contrast laser systems.

Delay-shift and asymmetric broadening of pre-pulses by post-pulses in a petawatt laser facility.

The temporal contrast of high-peak-power lasers is usually limited by pre-pulses, which are generally produced by post-pulses due to the nonlinearity of the active medium. The reason for the conversion between pre-pulse and post-pulse is now well known, but the mechanisms for the delay-shift and asymmetric broadening of the newly generated pre-pulse are not yet clear. In this work, a novel, to the best of our knowledge, numerical model combining the nonlinear Schrödinger equation and the Frantz-Nodvik equation is proposed to investigate the underlying mechanisms for the "distortion" of the pre-pulse. Numerical results show that the gain characteristics of Ti:sapphire amplifiers can only make a minor change on the temporal profile of the pre-pulse, but the high-order dispersion is the main cause for the delay-shift and asymmetric broadening of the pre-pulse, and the effects are more significant for the initial post-pulse with a relatively larger delay.

Angular dispersion compensation for ultra-broadband pulses by using a cascaded prism and hollow-core fiber configuration.

In this paper, we report that the angular dispersion of the output pulses in a nonlinear process can be efficiently compensated by using a cascaded prism(s) and short hollow-core fiber (HCF) configuration. Here, the prism(s) is used to suppress the angular dispersion and transform it into spatial chirp, while the HCF is used for removing this spatial chirp and the residual angular dispersion, which can also significantly improve the beam quality. The feasibility of this novel method is numerically and experimentally investigated with the ultra-broadband idler pulses centered at 1250 nm wavelength and generated by an LBO crystal based non-collinear optical parametric amplifier. The proof-of-principle experiment shows that the angular dispersion can be effectively removed and ultra-broadband idler pulses with good spectral quality and spatial profile can be obtained. The total transmission efficiency in the experiment is around 67% and the measured M x2 and M y2 can reach 1.12 and 1.04, respectively. To the best of our knowledge, this is the first reported ultra-broadband angular dispersion compensation scheme combining prism(s) and HCF, which can remarkably eliminate the angular dispersion while simultaneously possesses high efficiency, good spectral and beam spatial quality.

Investigation and suppression of pre-pulses on nanosecond time scale in the SULF-1PW laser.

It is of crucial significance to investigate and suppress pre-pulses on nanosecond time scale because the intense pre-plasma generated by them may have enough time to expand and, thus, cause fatal impact on laser-matter interactions. In this research, we analyze the potential origins of pre-pulses on nanosecond time scale in a typical Ti:sapphire chirped pulse amplification laser system. Based on the analysis, the initial status of these generated pre-pulses in the SULF-1PW laser is measured and investigated. Then different measures, including fine control on the time synchronization and the replacement for the Ti:sapphire, are adopted in the SULF-1PW laser to suppress these pre-pulses with respective origins, which can promote the energy ratio between the main pulse and these pre-pulses by 2-3 orders of magnitude. This research not only improves the temporal contrast of the SULF-1PW laser on nanosecond time scale but also provides beneficial guidance for the design and construction of similar laser facilities.

Performance improvement of a nonlinear temporal filter by using cascaded femtosecond optical parametric amplification.

In this paper, we report that the conversion efficiency and spectrum of femtosecond optical parametric amplification (fs-OPA) can be significantly enhanced by employing a compact cascaded femtosecond OPA (CF-OPA) scheme with the self-compensation of the temporal walk-off between two nonlinear gain media. Correspondingly, the gain related temporal contrast can also be improved. The feasibility of the CF-OPA method using three cascaded BBO crystals is numerically and experimentally analyzed. Moreover, by replacing the conventional fs-OPA with the CF-OPA and optimizing the design, the performance of a nonlinear temporal filter combining cross-polarized wave generation and fs-OPA is comprehensively improved. The experimental results demonstrate the superiority of the CF-OPA scheme, which can generate high-performance cleaned pulses at 1 kHz repetition rate with energy of 340µJ, energy fluctuation below 0.9% (RMS), spectral width of 97 nm (FWHM), Fourier-transform-limited pulse width of 12 fs and temporal contrast better than 10-12. To the best of our knowledge, this is the first reported temporal walk-off self-compensated quasi-collinear CF-OPA geometry adopting three cascaded BBO crystals, which can be easily generalized to other wavelengths or nonlinear crystals. The above nonlinear temporal filter with a CF-OPA scheme has the rarest comprehensive parameters, which can provide excellent seed pulses for PW and 10 PW class femtosecond laser systems.

Numerical analysis of the DKDP-based high-energy optical parametric chirped pulse amplifier for a 100 PW class laser.

An optical parametric chirped pulse amplifier (OPCPA) based on a large-aperture DKDP crystal and pumped by a 10 kJ level Nd:glass laser can serve as the final amplifier for a 100 PW level laser. A comprehensive numerical investigation on such a high-energy OPCPA is presented in this work. The effects on the efficiency-bandwidth product induced by the deuteration level, absorption loss, temperature variation, and optimization of zero-phase-mismatch wavelength (ZPMW) are analyzed in detail. Based on the analysis above, a three-dimensional numerical simulation taking into account the effects of pumping depletion, diffraction, and walk-off shows that, by optimization of ZPMW, broadband (over 210 nm spectral width in FWHM) and high efficiency (${\gt}37\%$) amplification can be realized in the DKDP crystal even with a moderate deuteration level of 70%, which can relax the requirement of a high deuteration level in a large-aperture DKDP crystal. The numerical analysis can provide meaningful guidance for the design and construction of 100 PW class laser systems.

A novel design of double chirped pulse amplification laser systems for fourth-order dispersion control.

A novel design of double chirped pulse amplification laser systems implementing a combination of negatively and positively chirped pulse amplification is proposed for the first time. Without utilizing any extra dispersion compensation element, this design can sufficiently cancel out the second-, third- and especially fourth-order dispersion simultaneously, just by optimizing the parameters of the stretcher and compressor in first chirped pulse amplification stage which applies negatively chirped pulse amplification. The numerical results indicate that near Fourier-transform-limited pulse duration about 20fs can be achieved in high-peak-power femtosecond laser systems up to multi-Petawatt level. This design not only provides a feasible solution for the dispersion control in high-contrast and high-peak-power femtosecond laser systems, but also can avoid the degradation of temporal contrast induced by seed energy loss in the presence of additional dispersion compensation components.

Investigation of the temporal contrast evolution in a 10-PW-level Ti:sapphire laser facility.

We have theoretically and experimentally investigated the evolution of the temporal contrast in a 10-PW-level Ti:sapphire laser in the Shanghai Superintense Ultrafast Laser Facility (SULF). The effects induced by the grism pair, spectral shaping filter, and increase in gain on the temporal contrast were investigated. First, it was found that the energy loss of clean seed pulses in the grism pair is a major factor in contrast degradation. Because of the low transmission efficiency of the grism pair (~10%), the temporal contrast is degraded by one order of magnitude. Second, the spectral shaping filter in the regenerative amplifier degrades the temporal contrast by increasing the intracavity loss. Finally, as the amplified spontaneous emission pedestal experiences gain more than the main pulse in Ti:sapphire amplifiers, particularly during saturated amplification, the temporal contrast will further deteriorate as the gain increases in multi-stage Ti:sapphire amplifiers. In addition, the effect on the temporal contrast induced by the extraction during pumping technique in large-aperture Ti:sapphire amplifiers has been considered. According to the investigations described above, the design of the SULF can be further improved. It is predicted that a temporal contrast of over 10-11 can be achieved at a peak power of 10 PW following the improvements. The investigations conducted in this study can provide guidelines for improving the temporal contrast in ultrahigh-peak-power Ti:sapphire lasers.

Gut Microbiota Combined with Serum Metabolomics to Investigate the Hypoglycemic Effect of Actinidia arguta Leaves.

Actinidia arguta leaves (AAL) are an excellent source of bioactive components for the food industry and possess many functional properties. However, the hypoglycemic effect and mechanism of AAL remain unclear. The aim of this work was to investigate the potential hypoglycemic effect of AAL and explore its possible mechanism using 16S rRNA sequencing and serum metabolomics in diabetic mice induced by high-fat feeding in combination with streptozotocin injection. A total of 25 flavonoids from AAL were isolated and characterized, and the contents of the extract from the AAL ranged from 0.14 mg/g DW to 8.97 mg/g DW. The compound quercetin (2) had the highest content of 8.97 ± 0.09 mg/g DW, and the compound kaempferol-3-O-(2'-O-D-glucopyl)-ß-D-rutinoside (12) had the lowest content of 0.14 ± 0.01 mg/g DW. In vivo experimental studies showed that AAL reduced blood glucose and cholesterol levels, improved insulin sensitivity, and ameliorated oxidative stress and liver and kidney pathological damage. In addition, gut microbiota analysis found that AAL significantly reduced the F/B ratio, enriched the beneficial bacteria Bacteroides and Bifidobacterium, and inhibited the harmful bacteria Lactobacillus and Desulfovibrio, thereby playing an active role in intestinal imbalance. In addition, metabolomics analysis showed that AAL could improve amino acid metabolism and arachidonic acid metabolism, thereby exerting a hypoglycemic effect. This study confirmed that AAL can alleviate type 2 diabetes mellitus (T2DM) by regulating intestinal flora and interfering with related metabolic pathways, providing a scientific basis for its use as a dietary supplement and for further exploration of the mechanism of AAL against T2DM.

Nontargeted metabolomic analysis of four different parts of Actinidia arguta by UPLC-Q-TOF-MSE.

Actinidia arguta, an edible berry plant with high nutritional values, has been widely used in Asian countries as a food and traditional medicinal herb. The well-recognized health-promoting properties of A. arguta were associated with its bioactive components in its different botanical parts. To rapidly screen and identify chemical components and simultaneously determine the potential metabolites from different parts of A. arguta, UPLC-Q-TOF-MSE coupled with UNIFI platform and multivariate statistical analysis approach was established in this study. As a result, a total of 107 components were identified from the four different parts of A. arguta, in which 31 characteristic chemical markers were discovered among them, including 12, 8, 6, and 5 compounds from the fruits, leaves, roots, and stems, respectively. These results suggested that the combination of UPLC-Q-TOF-MSE and metabolomic analysis is a powerful method to rapidly screen characteristic markers for the quality control of A. arguta.