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1.
Neuroradiology ; 34(3): 241-4, 1992.
Artículo en Inglés | MEDLINE | ID: mdl-1630620

RESUMEN

A case of rare intraspinal sparganosis treated by surgical excision is described. In this 59-year-old male with paraparesis and voiding problem, an intradural mass was noted on myelogram. Magnetic resonance (MR) and computed tomographic appearance of spinal and associated cerebral lesion are illustrated and possible route of migration discussed. This represents, to our knowledge, the first MRI demonstration of intraspinal sparganosis reported in the literature.


Asunto(s)
Esparganosis/complicaciones , Estenosis Espinal/etiología , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Mielografía , Esparganosis/diagnóstico , Esparganosis/diagnóstico por imagen , Enfermedades de la Médula Espinal/diagnóstico , Enfermedades de la Médula Espinal/diagnóstico por imagen , Estenosis Espinal/diagnóstico , Estenosis Espinal/diagnóstico por imagen
2.
J Clin Ultrasound ; 29(5): 273-8, 2001 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-11486321

RESUMEN

PURPOSE: We compared the Doppler sonographic findings in the penile cavernosal artery (arteria profunda penis) after intraurethral instillation and intracorporeal injection of prostaglandin E1 (PGE1) to evaluate the hemodynamic changes during drug-induced erection. METHODS: Twenty healthy male volunteers were enrolled in the study. Ten subjects (intraurethral group) were examined with Doppler sonography of the penile cavernosal artery after intraurethral administration of 1 mg of PGE1. The remaining 10 subjects (intracorporeal group) underwent Doppler sonography of the cavernosal artery after intracorporeal injection of 5 microg of PGE1. The peak systolic velocity, minimal diastolic velocity, and resistance index were determined at 5-minute intervals for 30 minutes following administration of PGE1 in both groups. The results were compared between the 2 groups. RESULTS: The peak systolic velocity in the intraurethral group increased progressively from a mean of 31.1 cm/second at 5 minutes to 65.6 cm/second at 30 minutes after intraurethral administration of PGE1. In the intracorporeal group, the mean peak systolic velocity ranged from 44.1 to 83.2 cm/second, reached a maximum at 10 minutes, and then decreased continuously through 30 minutes after intracorporeal injection of PGE1. The mean peak systolic velocities were significantly higher in the intracorporeal group at 10 and 15 minutes (p < or = 0.05); the mean minimal diastolic velocities were significantly lower in the intracorporeal group at 15, 20, and 25 minutes (p < or = 0.05); and the mean resistance indices were significantly higher in the intracorporeal group at all time points except 5 minutes (p < or = 0.05). CONCLUSIONS: The intracorporeal injection of PGE1 produced a greater vasoactive response in the cavernosal artery than did intraurethral instillation.


Asunto(s)
Alprostadil/farmacología , Disfunción Eréctil/diagnóstico por imagen , Pene/irrigación sanguínea , Pene/diagnóstico por imagen , Adulto , Alprostadil/administración & dosificación , Hemodinámica , Humanos , Masculino , Ultrasonografía Doppler , Uretra
3.
Bioorg Med Chem Lett ; 8(13): 1607-12, 1998 Jul 07.
Artículo en Inglés | MEDLINE | ID: mdl-9873399

RESUMEN

The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2 = NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety.


Asunto(s)
Antiinfecciosos/síntesis química , Antiinfecciosos/farmacología , Carbapenémicos/síntesis química , Carbapenémicos/farmacología , Animales , Antiinfecciosos/farmacocinética , Área Bajo la Curva , Carbapenémicos/farmacocinética , Dosificación Letal Mediana , Ratones , Pruebas de Sensibilidad Microbiana
4.
Planta Med ; 64(6): 500-3, 1998 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-9741293

RESUMEN

Ginseng saponin metabolites produced by human intestinal bacteria were evaluated for antigenotoxic properties by testing their effects on benzo[a]pyrene (B[a]P)-induced mutagenicity and clastogenicity. They include 20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol (IH-901), 20-O-(alpha-D-arabinopyranosyl(1-->6)-beta-D-glucopyranosyl]- 20(S)-protopanaxadiol (IH-902) and 20-O-[alpha-D-arabinofuranosyl(1-->6)-beta-D-glucopyranosyl]-20(S)- protopanaxadiol (IH-903). IH-901, IH-902 and IH-903 inhibited the mutagenicity of B[a]P in a dose-dependent manner. In the chromosome aberration assay, IH-901 and IH-903 reduced the frequency of chromosome aberration induced by B[a]P. These results suggest that the ginseng saponin metabolites tested in the present study have potential as chemopreventive agents.


Asunto(s)
Antimutagênicos/química , Antimutagênicos/farmacología , Benzo(a)pireno/toxicidad , Aberraciones Cromosómicas , Intestinos/microbiología , Microsomas Hepáticos/metabolismo , Panax , Plantas Medicinales , Salmonella typhimurium/genética , Saponinas/metabolismo , Saponinas/farmacología , Animales , Benzo(a)pireno/antagonistas & inhibidores , Línea Celular , Cricetinae , Cricetulus , Humanos , Pulmón , Masculino , Pruebas de Mutagenicidad , Ratas , Ratas Sprague-Dawley , Salmonella typhimurium/efectos de los fármacos , Intercambio de Cromátides Hermanas
5.
Radiology ; 216(3): 758-63, 2000 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-10966707

RESUMEN

PURPOSE: To investigate the technical feasibility and clinical effectiveness of a polyurethane-covered expandable nitinol stent in the treatment of malignant gastroduodenal obstructions. MATERIALS AND METHODS: The stent was constructed in-house by weaving a single thread of 0.2-mm nitinol wire in a tubular configuration and was covered with polyurethane solution by means of a dipping method. With fluoroscopic guidance, the stent was placed in 19 consecutive patients with malignant gastric outlet obstruction (n = 15) or duodenal obstruction (n = 4). All patients had severe nausea and recurrent vomiting, and their obstructions were inoperable. RESULTS: Stent placement was technically successful in all but one patient. After stent placement, symptoms improved in all but one patient, who had another stenosis at the proximal jejunum. One patient with stent placement in the second portion of the duodenum became jaundiced. During the mean follow-up of 11 weeks, stent migration occurred in five patients 1-4 days after the procedure. All patients with stent migration were treated by means of placing a second, uncovered nitinol stent. Two of these five patients showed recurrence of stricture because of tumor ingrowth; they underwent coaxial placement of a third, covered nitinol stent with good results. CONCLUSION: Placement of a polyurethane-covered expandable nitinol stent seems to be technically feasible and effective for palliative treatment of inoperable malignant gastroduodenal obstructions. Stent migration, however, is problematic and requires further investigation.


Asunto(s)
Materiales Biocompatibles Revestidos , Neoplasias Duodenales/terapia , Obstrucción Duodenal/terapia , Obstrucción de la Salida Gástrica/terapia , Cuidados Paliativos , Neoplasias Pancreáticas/terapia , Estenosis Pilórica/terapia , Stents , Neoplasias Gástricas/terapia , Adulto , Anciano , Anciano de 80 o más Años , Aleaciones , Neoplasias Duodenales/diagnóstico por imagen , Obstrucción Duodenal/diagnóstico por imagen , Obstrucción Duodenal/etiología , Estudios de Factibilidad , Femenino , Obstrucción de la Salida Gástrica/diagnóstico por imagen , Obstrucción de la Salida Gástrica/etiología , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Pancreáticas/diagnóstico por imagen , Poliuretanos , Diseño de Prótesis , Falla de Prótesis , Estenosis Pilórica/diagnóstico por imagen , Estenosis Pilórica/etiología , Radiografía , Neoplasias Gástricas/diagnóstico por imagen
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