1.
Org Lett
; 4(18): 3087-9, 2002 Sep 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12201723
RESUMEN
[reaction: see text] A highly convergent synthesis of the angiogenesis inhibitor luminacin D has been achieved in 13 linear steps (19 steps total, 5.3% overall yield) utilizing a samarium(II) iodide-mediated mixed tandem aldol/Evans-Tishchenko reaction to construct the carbohydrate precursor. The modular synthetic design will allow derivatization at key positions necessary for biochemical mode of action studies.