Búsqueda | BVS CLAP/SMR-OPS/OMS

1.

Ubiquitination at the lysine 27 residue of the Parkin ubiquitin-like domain is suggestive of a new mechanism of Parkin activation.

Liu, Jun-Yi; Inoshita, Tsuyoshi; Shiba-Fukushima, Kahori; Yoshida, Shigeharu; Ogata, Kosuke; Ishihama, Yasushi; Imai, Yuzuru; Hattori, Nobutaka.

Hum Mol Genet ; 31(15): 2623-2638, 2022 08 17.

Artículo en Inglés | MEDLINE | ID: mdl-35313349

2.

Pathogenesis of Parkinson's disease: from hints from monogenic familial PD to biomarkers.

Hattori, Nobutaka; Funayama, Manabu; Imai, Yuzuru; Hatano, Taku.

J Neural Transm (Vienna) ; 2024 Mar 13.

Artículo en Inglés | MEDLINE | ID: mdl-38478097

3.

High-fat diet-induced activation of SGK1 promotes Alzheimer's disease-associated tau pathology.

Elahi, Montasir; Motoi, Yumiko; Shimonaka, Shotaro; Ishida, Yoko; Hioki, Hiroyuki; Takanashi, Masashi; Ishiguro, Koichi; Imai, Yuzuru; Hattori, Nobutaka.

Hum Mol Genet ; 30(18): 1693-1710, 2021 08 28.

Artículo en Inglés | MEDLINE | ID: mdl-33890983

4.

Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms.

Kato, Shun; Arasaki, Kohei; Tokutomi, Natsuki; Imai, Yuzuru; Inoshita, Tsuyoshi; Hattori, Nobutaka; Sasaki, Taeko; Sato, Miyuki; Wakana, Yuichi; Inoue, Hiroki; Tagaya, Mitsuo.

J Cell Sci ; 134(22)2021 11 15.

Artículo en Inglés | MEDLINE | ID: mdl-34704591

5.

Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy.

Sugo, Masashi; Kimura, Hana; Arasaki, Kohei; Amemiya, Toshiki; Hirota, Naohiko; Dohmae, Naoshi; Imai, Yuzuru; Inoshita, Tsuyoshi; Shiba-Fukushima, Kahori; Hattori, Nobutaka; Cheng, Jinglei; Fujimoto, Toyoshi; Wakana, Yuichi; Inoue, Hiroki; Tagaya, Mitsuo.

EMBO J ; 37(21)2018 11 02.

Artículo en Inglés | MEDLINE | ID: mdl-30237312

6.

α-Synuclein V15A Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid-Binding Property.

Daida, Kensuke; Shimonaka, Shotaro; Shiba-Fukushima, Kahori; Ogata, Jun; Yoshino, Hiroyo; Okuzumi, Ayami; Hatano, Taku; Motoi, Yumiko; Hirunagi, Tomoki; Katsuno, Masahisa; Shindou, Hideo; Funayama, Manabu; Nishioka, Kenya; Hattori, Nobutaka; Imai, Yuzuru.

Mov Disord ; 37(10): 2075-2085, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-35894540

7.

Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling.

Mori, Akio; Hatano, Taku; Inoshita, Tsuyoshi; Shiba-Fukushima, Kahori; Koinuma, Takahiro; Meng, Hongrui; Kubo, Shin-Ichiro; Spratt, Spencer; Cui, Changxu; Yamashita, Chikara; Miki, Yoshimi; Yamamoto, Kei; Hirabayashi, Tetsuya; Murakami, Makoto; Takahashi, Yoshikazu; Shindou, Hideo; Nonaka, Takashi; Hasegawa, Masato; Okuzumi, Ayami; Imai, Yuzuru; Hattori, Nobutaka.

Proc Natl Acad Sci U S A ; 116(41): 20689-20699, 2019 10 08.

Artículo en Inglés | MEDLINE | ID: mdl-31548400

8.

Mutations in CHCHD2 cause α-synuclein aggregation.

Ikeda, Aya; Nishioka, Kenya; Meng, Hongrui; Takanashi, Masashi; Hasegawa, Iwao; Inoshita, Tsuyoshi; Shiba-Fukushima, Kahori; Li, Yuanzhe; Yoshino, Hiroyo; Mori, Akio; Okuzumi, Ayami; Yamaguchi, Akihiro; Nonaka, Risa; Izawa, Nana; Ishikawa, Kei-Ichi; Saiki, Hidemoto; Morita, Masayo; Hasegawa, Masato; Hasegawa, Kazuko; Elahi, Montasir; Funayama, Manabu; Okano, Hideyuki; Akamatsu, Wado; Imai, Yuzuru; Hattori, Nobutaka.

Hum Mol Genet ; 28(23): 3895-3911, 2019 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-31600778

9.

Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance.

Wu, Zhihao; Sawada, Tomoyo; Shiba, Kahori; Liu, Song; Kanao, Tomoko; Takahashi, Ryosuke; Hattori, Nobutaka; Imai, Yuzuru; Lu, Bingwei.

Genes Dev ; 27(2): 157-62, 2013 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-23348839

10.

A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson's Disease Affects LRRK2 Protein Levels.

Ogata, Jun; Hirao, Kentaro; Nishioka, Kenya; Hayashida, Arisa; Li, Yuanzhe; Yoshino, Hiroyo; Shimizu, Soichiro; Hattori, Nobutaka; Imai, Yuzuru.

Int J Mol Sci ; 22(7)2021 Apr 02.

Artículo en Inglés | MEDLINE | ID: mdl-33918221

11.

Editorial for the Special Issue "Animal Models of Parkinson's Disease and Related Disorders".

Imai, Yuzuru.

Int J Mol Sci ; 21(12)2020 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-32549241

12.

Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson's Disease.

Mori, Akio; Imai, Yuzuru; Hattori, Nobutaka.

Int J Mol Sci ; 21(9)2020 May 07.

Artículo en Inglés | MEDLINE | ID: mdl-32392751

13.

Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.

Inoshita, Tsuyoshi; Arano, Taku; Hosaka, Yuka; Meng, Hongrui; Umezaki, Yujiro; Kosugi, Sakiko; Morimoto, Takako; Koike, Masato; Chang, Hui-Yun; Imai, Yuzuru; Hattori, Nobutaka.

Hum Mol Genet ; 26(15): 2933-2948, 2017 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-28482024

14.

Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease.

Shiba-Fukushima, Kahori; Ishikawa, Kei-Ichi; Inoshita, Tsuyoshi; Izawa, Nana; Takanashi, Masashi; Sato, Shigeto; Onodera, Osamu; Akamatsu, Wado; Okano, Hideyuki; Imai, Yuzuru; Hattori, Nobutaka.

Hum Mol Genet ; 26(16): 3172-3185, 2017 08 15.

Artículo en Inglés | MEDLINE | ID: mdl-28541509

15.

Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia.

Imai, Yuzuru; Meng, Hongrui; Shiba-Fukushima, Kahori; Hattori, Nobutaka.

Int J Mol Sci ; 20(4)2019 Feb 20.

Artículo en Inglés | MEDLINE | ID: mdl-30791515

16.

The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.

Imai, Yuzuru; Kobayashi, Yoshito; Inoshita, Tsuyoshi; Meng, Hongrui; Arano, Taku; Uemura, Kengo; Asano, Takeshi; Yoshimi, Kenji; Zhang, Chang-Liang; Matsumoto, Gen; Ohtsuka, Toshiyuki; Kageyama, Ryoichiro; Kiyonari, Hiroshi; Shioi, Go; Nukina, Nobuyuki; Hattori, Nobutaka; Takahashi, Ryosuke.

PLoS Genet ; 11(9): e1005503, 2015 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-26355680

17.

Mitochondrial-Associated Membranes in Parkinson's Disease.

Hattori, Nobutaka; Arano, Taku; Hatano, Taku; Mori, Akio; Imai, Yuzuru.

Adv Exp Med Biol ; 997: 157-169, 2017.

Artículo en Inglés | MEDLINE | ID: mdl-28815529

18.

PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.

Shiba-Fukushima, Kahori; Inoshita, Tsuyoshi; Hattori, Nobutaka; Imai, Yuzuru.

PLoS Genet ; 10(6): e1004391, 2014 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-24901221

19.

Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

Shiba-Fukushima, Kahori; Arano, Taku; Matsumoto, Gen; Inoshita, Tsuyoshi; Yoshida, Shigeharu; Ishihama, Yasushi; Ryu, Kwon-Yul; Nukina, Nobuyuki; Hattori, Nobutaka; Imai, Yuzuru.

PLoS Genet ; 10(12): e1004861, 2014 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-25474007

20.

Mitochondrial damages and Parkinson's disease.