Asunto(s)
Anticuerpos Monoclonales Humanizados/uso terapéutico , Cobalto/efectos adversos , Dermatitis Alérgica por Contacto/tratamiento farmacológico , Dermatitis Alérgica por Contacto/etiología , Níquel/efectos adversos , Stents/efectos adversos , Enfermedad Coronaria/terapia , Humanos , Persona de Mediana EdadRESUMEN
Lichen amyloidosis is a subtype of primary localized cutaneous amyloidosis (PLCA), which presents as discrete, firm, closely-set 1-3mm, dome-shapedbrown papules commonly involving the anterior aspect of shins and extensor surfaces of forearms. We present a case of an otherwise healthy man in his 30s with solitary facial involvement of lichen amyloidosis, which is very uncommon.
Asunto(s)
Amiloidosis Familiar/patología , Dermatosis del Cuero Cabelludo/patología , Enfermedades Cutáneas Genéticas/patología , Adulto , Biopsia , Frente , Humanos , Masculino , Cuero Cabelludo/patologíaRESUMEN
Tick bites can cause a number of local inflammatory reactions, which are often difficult to differentiate from those induced by other arthropod bites or stings. These include erythematous nodular or pustular lesions, erosive plaques, annular lesions of erythema chronicum migrans, and both scarring and nonscarring inflammatory alopecia. We report a case of nonscarring alopecia in a 21-year-old male who reported a recent history of tick bite to the scalp. The biopsy demonstrated a dense pseudolymphomatous inflammatory infiltrate with numerous eosinophils associated with hair follicle miniaturization and an elevated catagen-telogen count. Signs of external rubbing, including lichen simplex chronicus and the "hamburger sign", were also visualized and are indicative of the associated pruritus. To the authors' knowledge, this is the fifth report of nonscarring tick bite alopecia in the literature and the first in an adult patient. This text will review the classic clinical presentation, histologic findings, and proposed mechanism of tick bite alopecia.
Asunto(s)
Alopecia/parasitología , Dermatosis del Cuero Cabelludo/parasitología , Cuero Cabelludo/parasitología , Enfermedades Cutáneas Parasitarias/parasitología , Mordeduras de Garrapatas/parasitología , Adolescente , Alopecia/patología , Biopsia , Niño , Preescolar , Femenino , Humanos , Masculino , Mucinosis Folicular/parasitología , Prurito/parasitología , Cuero Cabelludo/patología , Dermatosis del Cuero Cabelludo/patología , Enfermedades Cutáneas Parasitarias/patología , Mordeduras de Garrapatas/complicaciones , Mordeduras de Garrapatas/patología , Adulto JovenRESUMEN
Melanoma or melanoma metastases can rarely mimic blue nevi clinically and/or histologically, presenting a diagnostic pitfall for both the clinician and the dermatopathologist. We report a case of an invasive lentigo maligna melanoma with subsequent development of multiple, cutaneous blue nevus-like localized metastases followed by a distant metastasis, heralding widespread systemic metastases.
Asunto(s)
Peca Melanótica de Hutchinson/secundario , Nevo Azul/secundario , Neoplasias Cutáneas/patología , Anciano de 80 o más Años , Biomarcadores de Tumor/análisis , Biopsia , Diagnóstico Diferencial , Resultado Fatal , Humanos , Peca Melanótica de Hutchinson/química , Peca Melanótica de Hutchinson/cirugía , Antígeno MART-1/análisis , Masculino , Valor Predictivo de las Pruebas , Neoplasias Cutáneas/química , Neoplasias Cutáneas/cirugía , Coloración y Etiquetado , Factores de Tiempo , Resultado del TratamientoRESUMEN
Meyerson's phenomenon is a well-documented inflammatory reaction described in a variety of cutaneous lesions, including the original description in nevocellular nevi (1). Such an inflammatory reaction was subsequently described in melanocytic and a sundry of nonmelanocytic lesions alike, including vascular malformations (2-11). We present three cases of infants with nevus sebaceus on the scalp, which were obscured by an eczematous, eosinophilic reaction reminiscent of that first described by Meyerson. Two of the patients had concomitant atopic dermatitis, but one had no association. Recognition of this secondary feature is important in establishing the correct diagnosis.
Asunto(s)
Eccema/patología , Nevo Pigmentado/patología , Neoplasias Cutáneas/patología , Femenino , Humanos , Lactante , Masculino , Cuero Cabelludo/patologíaRESUMEN
Scleromyxedema is a rare variant of lichen myxedematosus. In addition to cutaneous manifestations, scleromyxedema often presents with systemic manifestations, including dysphagia, proximal muscle weakness, central nervous system disturbances, encephalopathy, and restrictive lung disease. It is almost always associated with paraproteinemia, usually IgG with gamma light chains. We review the literature on scleromyxedema associated with neurologic symptoms and present a case of a 49-year-old woman with encephalopathy attributable to scleromyxedema.
Asunto(s)
Encefalopatías/etiología , Escleromixedema/complicaciones , Escleromixedema/patología , Encefalopatías/psicología , Confusión/etiología , Femenino , Humanos , Persona de Mediana Edad , Escleromixedema/terapiaAsunto(s)
Enfermedades de la Uña/patología , Enfermedades de la Uña/cirugía , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/cirugía , Anciano , Biopsia con Aguja , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Masculino , Enfermedades Raras , Medición de Riesgo , Rondas de Enseñanza , Pulgar , Resultado del TratamientoRESUMEN
Erythema multiforme is histologically characterized by liquefactive degeneration along the dermal-epidermal junction, necrotic keratinocytes and a lymphocytic infiltrate. We report a 10-year-old boy with recurrent erythema multiforme major of undetermined etiology with unusual histologic findings. A skin biopsy taken at day 2 of his eruption revealed histologic features otherwise characteristic of erythema multiforme, but mediated instead by a CD68-positive infiltrate, resembling cutaneous Kikuchi's disease. To the best of our knowledge this is the first reported case of 'histiocytic' erythema multiforme.
Asunto(s)
Eritema Multiforme/patología , Histiocitos/patología , Antígenos CD/metabolismo , Antígenos de Diferenciación Mielomonocítica/metabolismo , Niño , Eritema Multiforme/tratamiento farmacológico , Eritema Multiforme/fisiopatología , Humanos , Inmunoglobulinas Intravenosas/uso terapéutico , MasculinoRESUMEN
Interstitial granulomatous drug reactions are an uncommon entity presenting as asymptomatic, annular, erythematous to violaceous plaques. The incidence of such reactions has been increasing with the use of biologic agents. We report, to the best of our knowledge, the first such reaction to the interleukin (IL)-1 inhibitor anakinra. Our patient presented with pink dermal plaques and nodules in the periaxillary region which resolved with discontinuation of anakinra and recurred upon restarting anakinra. Biopsy revealed a diffuse dermal infiltrate of lymphocytes and histiocytes with interspersed neutrophils and eosinophils. Fragmentation and degeneration of collagen and elastic fibers was also present. Withdrawal of anakinra led to complete resolution of the lesions. Interstitial granulomatous drug reactions are increasing in frequency and we add anakinra to the list of causative agents.
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Antirreumáticos/efectos adversos , Artritis Reumatoide/tratamiento farmacológico , Erupciones por Medicamentos/etiología , Granuloma/etiología , Proteína Antagonista del Receptor de Interleucina 1/efectos adversos , Erupciones por Medicamentos/patología , Femenino , Granuloma/patología , Humanos , Persona de Mediana EdadAsunto(s)
Biopsia/normas , Dermatología/normas , Patología Clínica/normas , Biopsia/métodos , HumanosRESUMEN
BACKGROUND: The CD30-positive lymphoproliferative disorders lymphomatoid papulosis (LyP), primary cutaneous anaplastic large cell lymphoma (C-ALCL), and systemic anaplastic large cell lymphoma (S-ALCL) are lesions that overlap clinically, histopathologically, and immunophenotypically. Their biologic behaviors, however, vary considerably. In particular, lesions of LyP regress spontaneously while those of S-ALCL persist and often progress. Apoptosis has been suggested as the mechanism by which the lesions of LyP regress, but the underlying signaling pathways remain unclear. In this study, we used newly developed activation state-specific antibodies to demonstrate apoptosis signaling through the death receptor-mediated pathway regulated by FADD and caspase 3. METHODS: Dual immunohistochemistry for CD30 and activated forms of FADD and caspase 3 was performed on cutaneous biopsy specimens from 27 patients with CD30-positive lymphoproliferative disorders involving the skin. The patients included 18 with primary cutaneous CD30-positive LPDs (15 with LyP and 3 with C-ALCL) and 9 with S-ALCL. RESULTS: The proportion of CD30-positive cells expressing activated FADD was significantly different between primary cutaneous CD30-positive lymphoproliferative disorders and S-ALCL (36.4% vs. 14.5%, P = 0.0083). Expression of cleaved caspase 3 was also significantly different between primary cutaneous lesions and S-ALCL (9.2% vs. 1.9%, P = 0.048). CONCLUSIONS: Although a larger number of cases should be studied to validate these results, these data provide evidence that differences in signaling through the death-receptor apoptosis pathway mediated by FADD may be responsible for the varying biologic behaviors of CD30-positive lymphoproliferative disorders involving the skin.
Asunto(s)
Proteínas Adaptadoras Transductoras de Señales/metabolismo , Antígeno Ki-1/metabolismo , Linfoma Anaplásico de Células Grandes/metabolismo , Papulosis Linfomatoide/metabolismo , Neoplasias Cutáneas/metabolismo , Adulto , Anciano , Anciano de 80 o más Años , Apoptosis , Biomarcadores de Tumor/metabolismo , Biopsia , Caspasa 3 , Caspasas/metabolismo , Proteína de Dominio de Muerte Asociada a Fas , Femenino , Técnica del Anticuerpo Fluorescente Indirecta , Humanos , Técnicas para Inmunoenzimas , Etiquetado Corte-Fin in Situ , Linfoma Anaplásico de Células Grandes/patología , Papulosis Linfomatoide/patología , Masculino , Persona de Mediana Edad , Transducción de Señal , Neoplasias Cutáneas/patologíaAsunto(s)
Alopecia/etiología , Neoplasias de la Mama/patología , Neoplasias de Cabeza y Cuello/patología , Neoplasias Cutáneas/secundario , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Neoplasias de la Mama/secundario , Femenino , Folículo Piloso/patología , Neoplasias de Cabeza y Cuello/secundario , Humanos , Persona de Mediana EdadRESUMEN
Neutrophilic eccrine hidradenitis (NEH) is an acute, self-limited, inflammatory neutrophilic dermatosis. It is most commonly described in patients with acute myelogenous leukemia (AML) following chemotherapy. NEH generally presents as erythematous papules and plaques on the head, trunk, and extremities. Histologically, NEH is characterized by a neutrophilic infiltrate surrounding eccrine ducts and coils with occasional necrosis. We describe a case of NEH with an unusual presentation of annular plaques. A search of the literature revealed only one other case report of NEH presenting as an annular eruption.
Asunto(s)
Hidradenitis/diagnóstico , Huésped Inmunocomprometido , Leucemia Mieloide Aguda/tratamiento farmacológico , Leucemia Mieloide Aguda/inmunología , Inducción de Remisión , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Biopsia con Aguja , Estudios de Seguimiento , Hidradenitis/inmunología , Humanos , Inmunohistoquímica , Leucemia Mieloide Aguda/diagnóstico , Masculino , Recurrencia , Remisión Espontánea , Medición de RiesgoRESUMEN
IMPORTANCE: Nilotinib, a recently approved multitargeted tyrosine kinase inhibitor targeting the BCR-Abl translocation involved in chronic myelogenous leukemia, reportedly produces alopecia according to the package insert, but clinical and histologic descriptions of the alopecia are lacking. OBSERVATIONS: A 33-year-old woman with chronic myelogenous leukemia developed widespread alopecia involving scalp and body hair within weeks after starting nilotinib therapy. Biopsies revealed perifollicular lymphocytic inflammation and evidence of follicular injury but normal hair density, consistent with a nonscarring alopecia. CONCLUSIONS AND RELEVANCE: Nilotinib therapy may induce perifollicular inflammation and widespread persistent alopecia. We present the first clinical and histologic description of this potential adverse effect. Further investigation into the underlying mechanism of this adverse effect may produce insights into the hair growth cycle as well as potential therapeutic targets.