1.
Org Lett
; 21(23): 9564-9568, 2019 Dec 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-31769694
RESUMEN
A transition-metal-free three-component process that combines aldehydes, 3-(tributylstannyl)propargyl acetates formed in situ from readily available propargyl acetates, and trialkylboranes provides access to a range of 1,2,4-trisubstituted homopropargylic alcohols. The addition of diisopropylamine plays a crucial role in the selective formation of homopropargylic alcohols. Importantly, this methodology can be extended to a single-flask reaction sequence starting from propargyl acetates.