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1.
The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.
PLoS Pathog
; 9(1): e1003125, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23349632
2.
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Bioorg Med Chem Lett
; 19(17): 5209-13, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19631533
3.
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Bioorg Med Chem Lett
; 19(15): 4092-6, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19539468
4.
Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.
Bioorg Med Chem Lett
; 18(12): 3611-5, 2008 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18490160
5.
Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.
J Exp Med
; 215(5): 1315-1325, 2018 05 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29549113
6.
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
J Med Chem
; 49(14): 4425-36, 2006 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-16821801
7.
Evaluation of aminohydantoins as a novel class of antimalarial agents.
ACS Med Chem Lett
; 5(1): 89-93, 2014 Jan 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900778
8.
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
J Med Chem
; 53(6): 2656-60, 2010 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20196613
9.
Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists.
Bioorg Med Chem
; 14(24): 8219-48, 2006 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17011782
10.
Co-crystallization of Staphylococcus aureus peptide deformylase (PDF) with potent inhibitors.
Acta Crystallogr D Biol Crystallogr
; 58(Pt 12): 2153-6, 2002 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-12454484
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