Detection and recognition of metal surface corrosion based on CBG-YOLOv5s.

The automatic detection of the degree of surface corrosion on metal structures is of significant importance for assessing structural damage and safety. To effectively identify the corrosion status on the surface of coastal metal facilities, this study proposed a CBG-YOLOv5s model for metal surface corrosion detection, based on the YOLOv5s model. Firstly, we integrated the Convolutional Block Attention Module (CBAM) into the C3 module and developed the C3CBAM module. This module effectively enhanced the channel and spatial attention capabilities of the feature map, thereby improving the feature representation. Second, we introduced a multi-scale feature fusion concept in the feature fusion part of the model and added a small target detection layer to improve small target detection. Finally, we designed a lighter C3Ghost module, which reduced the number of parameters and the computational load of the model, thereby improving the running speed of the model. In addition, to verify the effectiveness of our method, we constructed a dataset containing 6000 typical images of metal surface corrosion and conducted extensive experiments on this dataset. The results showed that compared to the YOLOv5s model and several other commonly used object detection models, our method achieved superior performance in terms of detection accuracy and speed.

Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion.

T cell exhaustion has emerged as a major hurdle that impedes the clinical translation of stimulator of interferon genes (STING) agonists. It is crucial to explore innovative strategies to rejuvenate exhausted T cells and potentiate the antitumor efficacy. Here, we propose an approach utilizing MSA-2 as a STING agonist, along with nanoparticle-mediated delivery of mRNA encoding interleukin-12 (IL-12) to restore the function of T cells. We developed a lipid nanoparticle (DMT7-IL12 LNP) that encapsulated IL12 mRNA. Our findings convincingly demonstrated that the combination of MSA-2 and DMT7-IL12 LNP can effectively reverse the exhausted T cell phenotype, as evidenced by the enhanced secretion of cytokines, such as tumor necrosis factor alpha, interferon gamma, and Granzyme B, coupled with reduced levels of inhibitory molecules such as T cell immunoglobulin and mucin domain-3 and programmed cell death protein-1 on CD8+ T cells. Furthermore, this approach led to improved survival and tumor regression without causing any systemic toxicity in melanoma and lung metastasis models. These findings suggest that mRNA encoding IL-12 in conjunction with STING agonists has the potential to confer superior clinical outcomes, representing a promising advancement in cancer immunotherapy.

Flower-like TiO2 and TiO2@C composites prepared via a one-pot solvothermal method as anode materials for lithium-ion batteries: higher capacity and excellent cycling stability.

TiO2 is a promising and safe anode material for lithium-ion batteries. Nevertheless, its inferior electronic conductivity and inferior cycling capability have always limited its practical application. In this study, flower-like TiO2 and TiO2@C composites are produced by a simple one-pot solvothermal method. It is noticeable that the synthesis of TiO2 is carried out simultaneously with carbon coating. The flower-like TiO2 with a special morphology can decrease the distance of lithium ion diffusion, while the carbon coating improves the electronic conductivity of TiO2. At the same time, the carbon content of TiO2@C composites can be controlled by adjusting the amount of glucose. Compared with flower-like TiO2, TiO2@C composites have higher specific capacity and preferable cycling performance. It is noteworthy that the specific surface area of TiO2@C with a carbon content of 63.36% is 293.94 m2 g-1 and its capacity remains at 371.86 mAh g-1 after 1000 cycles at 1 A g-1. Other anode materials can also be prepared using this strategy.

Titanium dioxide-based anode materials for lithium-ion batteries: structure and synthesis.

Lithium-ion batteries (LIBs) have high energy density, long life, good safety, and environmental friendliness, and have been widely used in large-scale energy storage and mobile electronic devices. As a cheap and non-toxic anode material for LIBs, titanium dioxide (TiO2) has a good application prospect. However, its poor electrical conductivity leads to unsatisfactory electrochemical performance, which limits its large-scale application. In this review, the structure of three TiO2 polymorphs which are widely investigated are briefly described, then the preparation and electrochemical performance of TiO2 with different morphologies, such as nanoparticles, nanowires, nanotubes, and nanospheres, and the related research on the TiO2 composite materials with carbon, silicon, and metal materials are discussed. Finally, the development trend of TiO2-based anode materials for LIBs has been briefly prospected.