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This study analyzed the epidemiological and clinical features of dengue fever in Zhangshu, Jiangxi Province, in 2019 and provided evidence for the diagnosis, treatment, prevention, and control of dengue fever. A total of 718 dengue fever patients in Zhangshu in 2019 were involved. ELISA and qRT-PCR were used for pathogenic detection of dengue virus. Multiple adjuvant therapies were applied, and the condition of patients after treatment was examined. Patients were between the ages of 0.75 and 92 years old, and all of them had a fever. A total of 519 cases had fatigue, and 413 cases had generalized myalgia and bone ache; 356 cases had dry mouth, 289 cases had bitter taste, and 167 cases felt dry and bitter taste; 279 cases had rash, and 93 cases had pruritus; 587 cases had decreased leukocyte, among which, 7 cases had leukocyte lower than 1 × 10 [9]/L; 380 cases had a low platelet count, and the platelet count of 29 cases was lower than 50 × 10 [9]/L; 488 cases had increased aspartic transaminase, and 460 cases had increased alanine aminotransferase; 5 cases had a severe disease. It proved that the majority of dengue fever sufferers were adults, with the main clinical features being fever and rash and the chief injured organs being the blood system, liver, heart, and gastrointestinal tract. Besides, over 40% of patients had dry and bitter taste, and 12 cases had alopecia after discharge. It indicates that the incidence of dengue fever in Zhangshu is closely related to the sudden population flow and imported cases.
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Dengue/epidemiología , Brotes de Enfermedades , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Niño , Preescolar , China/epidemiología , Dengue/sangre , Dengue/etiología , Virus del Dengue/aislamiento & purificación , Ensayo de Inmunoadsorción Enzimática , Femenino , Humanos , Incidencia , Lactante , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , Factores Sexuales , Adulto JovenRESUMEN
The ionic diode structure has become one of the attractive structures in the field of moisture-based power generation. However, existing devices still suffer from poor moisture trapping, low surface charge, and inefficient ion separation, resulting in low output power. Moreover, water freezes at low temperatures (<0 °C), limiting the ionic diode structure to generate electricity in cold environments. In this paper, a moisture-enabled power generator has been designed and fabricated, which assembles a negatively charged ionic hydrogel film and a positively charged anodized aluminum oxide (AAO) film to construct a heterojunction. The hydrogel polymer network is modified with a large number of sulfonate groups that dissociate to provide nanoscale pores with high surface charge to improve the rectification ratio. And the lithium chloride (LiCl) salt with high hydration ability is added to the hydrogel as a moisture-trapping and anti-freezing component. Usually salt ions reduce the Debye length, so that the ion transport is finally not controlled by the electric double layer (EDL) and the rectification fails. Interestingly, due to the natural affinity of the hydrogel polymer network for LiCl, LiCl is locked on the hydrogel side and does not easily enter the AAO pores to change the distribution of EDL within the nanochannel. As a result, the device rectification ratio is almost independent of the amount of LiCl addition, demonstrating an excellent balance of high output power and high freeze resistance. Ultimately, the device exhibits excellent power generation performance in the -20 °C to 60 °C temperature range and 15% to 93% RH humidity range. Typically, under high humidity (93% RH) at room temperature (25 °C), it provides an open-circuit voltage of 1.25 V and a short-circuit current of 300 µA cm-2, with an on-load output power of up to 71.35 µW cm-2. Under medium humidity (50% RH) at low temperature (-20 °C), it provides an open-circuit voltage of 1.11 V and a short-circuit current of 15 µA cm-2.
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Considerable efforts have recently been made to augment the power density of moisture-enabled electric generators. However, due to the unsustainable ion/water molecule concentration gradients, the ion-directed transport gradually diminishes, which largely affects the operating lifetime and energy efficiency of generators. This work introduces an electrode chemistry regulation strategy into the ionic diode-type energy conversion structure, which demonstrates 1240 h power generation in ambient humidity. The electrode chemical regulation can be achieved by adding Cl-. The purpose is to destroy the passivation film on the electrode interface and provide a continuous path for ion-electron coupling conduction. Moreover, this device simultaneously satisfies the requirements of fast trapping of moisture molecules, high rectification ratio transport of ions, and sustained ion-to-electron current conversion. A single device can deliver an open-circuit voltage of about 1 V and a peak short-circuit current density of 350 µA cm-2. Finally, the first-principle calculations are carried out to reveal the mechanism by which the electrode surface chemistry affects the power generation performance.
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Tactile sensors play an important role in human-machine interaction (HMI). Compared to contact tactile sensing, which leaves physical hardware vulnerable to wear and tear, proximity sensing is better at reacting to remote events before physical contact. The apteronotus albifrons possess ion channel receptors for remote surroundings perception. Inspired by the relevant ion channel structure and self-powered operation mode, we designed a new proximity sensor with ion rectification characteristics and self-powered capability. This bio-inspired ion channel receptor exploits the hygroelectric effect to convert the humidity information into a series of current signals when the living organism approaches, and it is insensitive to non-aquatic non-organisms. The sensor offers high sensitivity (2.3 mm-1), a suitable range (0-10 mm) for close object detection, fast response (0.3 s), and fast recovery (2.5 s). The unique combination of bio-sensitivity, non-contact detection characteristics, and humidity-based power generation capabilities enriches the functionality of future HMI electronics. As a proof of concept, the sensor has been successfully applied in different scenarios such as human health management, early warning systems, non-contact switches to prevent virus transmission, object recognition, and finger trajectory detection.
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Técnicas Biosensibles , Humanos , Tacto/fisiología , ElectrónicaRESUMEN
Calcium is one of the essential minerals that enhances various biological activities, including the regulation of blood pressure, the prevention of osteoporosis and colorectal adenomas. Calcium-enriched edible mushrooms can be considered as one of the important daily sources of calcium in foods. Calcium accumulation in edible mushrooms is an effective way to enhance its activities because the organic state of calcium metabolites in edible mushrooms can be formed from the original inorganic calcium. The main calcium sources for calcium-enriched edible mushrooms' cultivation are CaCO3, CaCl2 or Ca(NO3)2. The growth and metabolic process of edible mushrooms are significantly influenced by calcium enrichment. Generally, Ca at low levels is good for the production of edible mushrooms, whereas the reverse phenomenon for the growth of edible mushrooms at high Ca contents is observed. In addition, metabolites, for example, phenolics, flavonoids, polysaccharides, enzymes, minerals, etc., are improved when edible mushrooms are enriched at a moderate level of calcium. This review summarized the literature regarding the influence of calcium enrichment on edible mushrooms' growth and major metabolites. Furthermore, the mechanisms of calcium enrichment in edible mushrooms were highlighted. Understanding calcium-enriched mechanisms in edible mushrooms would not only be beneficial to manipulate the cultivation of edible mushrooms having excellent biological activities and high levels of active Ca, but it would also contribute to the applications of calcium enrichment products in food industries.
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Building prosthetics indistinguishable from human limbs to accurately receive and transmit sensory information to users not only promises to radically improve the lives of amputees, but also shows potential in a range of robotic applications. Currently, a mainstream approach is to embed electrical or optical sensors with force/thermal sensing functions on the surface or inside of prosthetic fingers. Compared with electrical sensing technologies, tactile sensors based on stretchable optical waveguides have the advantages of easy fabrication, chemical safety, environmental stability, and compatibility with prosthetic structural materials. However, so far, research has mainly focused on the perception of finger joint motion or external press, and there is still a lack of study on optical sensors with fingertip tactile capabilities (such as texture, hardness, slip detection, etc.). Here we report a 3D printing prosthetic finger with flexible chromatic optical waveguides implanted at the fingertip. The finger achieves distributed displacement/force sensing detection, and exhibits high sensitivity, fast response and good stability. The finger can be used to conduct active sensory experiments, and the detection parameters include object contour, hardness, slip direction and speed, temperature, etc. Finally, exploratory research on identifying and manipulating objects is carried out with this finger. The developed prosthetic finger can artificially recreate touch perception and realize complex functions such as note-writing analysis and braille recognition.
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Dedos , Percepción del Tacto , Humanos , Dedos/fisiología , Extremidad Superior , Tacto/fisiología , Fenómenos MecánicosRESUMEN
The continuous energy-harvesting in moisture environment is attractive for the development of clean energy source. Controlling the transport of ionized mobile charge in intelligent nanoporous membrane systems is a promising strategy to develop the moisture-enabled electric generator. However, existing designs still suffer from low output power density. Moreover, these devices can only produce short-term (mostly a few seconds or a few hours, rarely for a few days) voltage and current output in the ambient environment. Here, we show an ionic diode-type hybrid membrane capable of continuously generating energy in the ambient environment. The built-in electric field of the nanofluidic diode-type PN junction helps the selective ions separation and the steady-state one-way ion charge transfer. This directional ion migration is further converted to electron transportation at the surface of electrodes via oxidation-reduction reaction and charge adsorption, thus resulting in a continuous voltage and current with high energy conversion efficiency.
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